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A4YHC9

- OGG1_METS5

UniProt

A4YHC9 - OGG1_METS5

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Protein
Probable N-glycosylase/DNA lyase
Gene
ogg, Msed_1676
Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity.UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei126 – 1261 By similarity

GO - Molecular functioni

  1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
  2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP

GO - Biological processi

  1. base-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciMSED399549:GH1O-1699-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
Gene namesi
Name:ogg
Ordered Locus Names:Msed_1676
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348)
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
ProteomesiUP000000242: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Probable N-glycosylase/DNA lyaseUniRule annotation
PRO_1000071834Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399549.Msed_1676.

Structurei

3D structure databases

ProteinModelPortaliA4YHC9.

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.

Phylogenomic databases

eggNOGiCOG1059.
HOGENOMiHOG000224507.
KOiK03653.
OMAiLDLYLWY.

Family and domain databases

Gene3Di1.10.340.30. 1 hit.
HAMAPiMF_00241. Ogg.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YHC9-1 [UniParc]FASTAAdd to Basket

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MLRKVVRDAR LRARVLERVE EFRLNKRASE RVWFRELVLC ILTANSSFIG    50
AFTALQYLGD LILYGSIEEI SSALKNAGYR FPNLKARYII ESRSYYGKLR 100
EIGRVADRDQ IEAREILLEI KGLGMKEASH FLRNMGYLDL AIIDRHILRF 150
FSDYLEDQKI SSKSKYFELE SVFRSIASAL DLPVGVLDLY VWYLKTGKLA 200
K 201
Length:201
Mass (Da):23,384
Last modified:May 29, 2007 - v1
Checksum:iCF5A8E7C4E5936A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000682 Genomic DNA. Translation: ABP95831.1.
RefSeqiYP_001191755.1. NC_009440.1.

Genome annotation databases

EnsemblBacteriaiABP95831; ABP95831; Msed_1676.
GeneIDi5105322.
KEGGimse:Msed_1676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000682 Genomic DNA. Translation: ABP95831.1 .
RefSeqi YP_001191755.1. NC_009440.1.

3D structure databases

ProteinModelPortali A4YHC9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399549.Msed_1676.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP95831 ; ABP95831 ; Msed_1676 .
GeneIDi 5105322.
KEGGi mse:Msed_1676.

Phylogenomic databases

eggNOGi COG1059.
HOGENOMi HOG000224507.
KOi K03653.
OMAi LDLYLWY.

Enzyme and pathway databases

BioCyci MSED399549:GH1O-1699-MONOMER.

Family and domain databases

Gene3Di 1.10.340.30. 1 hit.
HAMAPi MF_00241. Ogg.
InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view ]
PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
SMARTi SM00478. ENDO3c. 1 hit.
[Graphical view ]
SUPFAMi SSF48150. SSF48150. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
    Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
    Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51363 / DSM 5348.

Entry informationi

Entry nameiOGG1_METS5
AccessioniPrimary (citable) accession number: A4YHC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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