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Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites).UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei126UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyaseUniRule annotation
Including the following 2 domains:
8-oxoguanine DNA glycosylaseUniRule annotation (EC:3.2.2.-UniRule annotation)
DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation (EC:4.2.99.18UniRule annotation)
Short name:
AP lyaseUniRule annotation
Gene namesi
Name:oggUniRule annotation
Ordered Locus Names:Msed_1676
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
Proteomesi
  • UP000000242 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000718341 – 201Probable N-glycosylase/DNA lyaseAdd BLAST201

Interactioni

Protein-protein interaction databases

STRINGi399549.Msed_1676.

Structurei

3D structure databases

ProteinModelPortaliA4YHC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04357. Archaea.
COG1059. LUCA.
HOGENOMiHOG000224507.
KOiK03653.
OMAiELCFCIL.

Family and domain databases

CDDicd00056. ENDO3c. 1 hit.
Gene3Di1.10.340.30. 1 hit.
HAMAPiMF_00241. Ogg. 1 hit.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YHC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRKVVRDAR LRARVLERVE EFRLNKRASE RVWFRELVLC ILTANSSFIG
60 70 80 90 100
AFTALQYLGD LILYGSIEEI SSALKNAGYR FPNLKARYII ESRSYYGKLR
110 120 130 140 150
EIGRVADRDQ IEAREILLEI KGLGMKEASH FLRNMGYLDL AIIDRHILRF
160 170 180 190 200
FSDYLEDQKI SSKSKYFELE SVFRSIASAL DLPVGVLDLY VWYLKTGKLA

K
Length:201
Mass (Da):23,384
Last modified:May 29, 2007 - v1
Checksum:iCF5A8E7C4E5936A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA. Translation: ABP95831.1.
RefSeqiWP_012021618.1. NC_009440.1.

Genome annotation databases

EnsemblBacteriaiABP95831; ABP95831; Msed_1676.
GeneIDi5105322.
KEGGimse:Msed_1676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA. Translation: ABP95831.1.
RefSeqiWP_012021618.1. NC_009440.1.

3D structure databases

ProteinModelPortaliA4YHC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399549.Msed_1676.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP95831; ABP95831; Msed_1676.
GeneIDi5105322.
KEGGimse:Msed_1676.

Phylogenomic databases

eggNOGiarCOG04357. Archaea.
COG1059. LUCA.
HOGENOMiHOG000224507.
KOiK03653.
OMAiELCFCIL.

Family and domain databases

CDDicd00056. ENDO3c. 1 hit.
Gene3Di1.10.340.30. 1 hit.
HAMAPiMF_00241. Ogg. 1 hit.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiOGG1_METS5
AccessioniPrimary (citable) accession number: A4YHC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 29, 2007
Last modified: November 2, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.