A4YHC9 (OGG1_METS5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable N-glycosylase/DNA lyase

Including the following 2 domains:

1. 8-oxoguanine DNA glycosylase
   EC=3.2.2.-
2. DNA-(apurinic or apyrimidinic site) lyase
   Short name=AP lyase
   EC=4.2.99.18

Gene names

Name:	ogg
Ordered Locus Names:	Msed_1676

Organism

Metallosphaera sedula (strain ATCC 51363 / DSM 5348) [Complete proteome] [HAMAP]

Taxonomic identifier

399549 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Metallosphaera › Metallosphaera sedula

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity. HAMAP-Rule MF_00241
Catalytic activity	The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. HAMAP-Rule MF_00241
Sequence similarities	Belongs to the type-2 OGG1 family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Molecular function	Glycosidase Hydrolase Lyase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological_process	base-excision repair Inferred from electronic annotation. Source: HAMAP
Molecular_function	DNA-(apurinic or apyrimidinic site) lyase activity Inferred from electronic annotation. Source: HAMAP hydrolase activity, hydrolyzing N-glycosyl compounds Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 201	201	Probable N-glycosylase/DNA lyase HAMAP-Rule MF_00241		PRO_1000071834
Sites
	Active site	126	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4YHC9 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: CF5A8E7C4E5936A1	FASTA	201	23,384
	10 20 30 40 50 60 MLRKVVRDAR LRARVLERVE EFRLNKRASE RVWFRELVLC ILTANSSFIG AFTALQYLGD 70 80 90 100 110 120 LILYGSIEEI SSALKNAGYR FPNLKARYII ESRSYYGKLR EIGRVADRDQ IEAREILLEI 130 140 150 160 170 180 KGLGMKEASH FLRNMGYLDL AIIDRHILRF FSDYLEDQKI SSKSKYFELE SVFRSIASAL 190 200 DLPVGVLDLY VWYLKTGKLA K

References

[1]

"The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism." Auernik K.S., Maezato Y., Blum P.H., Kelly R.M. Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51363 / DSM 5348.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000682 Genomic DNA. Translation: ABP95831.1.
RefSeq	YP_001191755.1. NC_009440.1.
3D structure databases
ProteinModelPortal	A4YHC9.
ModBase	Search...
Protein-protein interaction databases
STRING	399549.Msed_1676.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABP95831; ABP95831; Msed_1676.
GeneID	5105322.
KEGG	mse:Msed_1676.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1059.
HOGENOM	HOG000224507.
KO	K03653.
OMA	IIDRHIL.
ProtClustDB	PRK01229.
Enzyme and pathway databases
BioCyc	MSED399549:GH1O-1722-MONOMER.
Family and domain databases
Gene3D	1.10.340.30. 1 hit.
HAMAP	MF_00241. Ogg.
InterPro	IPR012092. DNA_glyclase/DNA_lyase_thermo. IPR011257. DNA_glycosylase. IPR003265. HhH-GPD_domain. [Graphical view]
PIRSF	PIRSF005954. Thrmst_ogg. 1 hit.
SMART	SM00478. ENDO3c. 1 hit. [Graphical view]
SUPFAM	SSF48150. DNA_glycsylse. 1 hit.
ProtoNet	Search...

Entry information

Entry name

OGG1_METS5

Accession

Primary (citable) accession number: A4YHC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	May 29, 2007
Last modified:	May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program