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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Msed_1664
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
Proteomesi
  • UP000000242 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000727691 – 447Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST447

Proteomic databases

PRIDEiA4YHB7

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi399549.Msed_1664

Structurei

3D structure databases

ProteinModelPortaliA4YHB7
SMRiA4YHB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00077 Archaea
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG093Z02N9

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

A4YHB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNHPWLPNI SRIKDMLREI GVDDVEQLFQ DVPRDLILRR ELKVGYDSPL
60 70 80 90 100
PEEDIRWRLN QVAERNLKLR YPPFLGAGAY PHSIPSVIRF ILSRSEFYTA
110 120 130 140 150
YTPYQPEVNQ GLLQGLFEYQ SLMAELLEMD VVNSSHYDWG GSLAEAVLMG
160 170 180 190 200
YRINGKRKVV IPESINPLHE EVLRTWVSGR ELEVVKIPVG KDGKIDLDFL
210 220 230 240 250
SSLNSDEISS IYIQQPNFFG VVETELEYVT DWARKNNVVS IMGVSPLSLG
260 270 280 290 300
LIKTPGELGF DIAVGDGQEL GIPLNFGGPY SGILATRMDM KLVRQMPGRI
310 320 330 340 350
VGMTQDSQGR RGFTLILQTR EQFARREKAT SNITTNEALI ALANAVYLSL
360 370 380 390 400
LGKEGIRELA TEIYKRSHYA LKRMEDEELG KRKWESDFFE EFTFVFRSDY
410 420 430 440
DRIHSELLRR GIHGGLRLGP REALFCVTEV HTKRAIDDLV NAMKEVA
Length:447
Mass (Da):50,941
Last modified:May 29, 2007 - v1
Checksum:i8CA448B5C336BF80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA Translation: ABP95819.1
RefSeqiWP_012021606.1, NC_009440.1

Genome annotation databases

EnsemblBacteriaiABP95819; ABP95819; Msed_1664
GeneIDi5104869
KEGGimse:Msed_1664

Similar proteinsi

Entry informationi

Entry nameiGCSPA_METS5
AccessioniPrimary (citable) accession number: A4YHB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 29, 2007
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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