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A4YHB7 (GCSPA_METS5) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Msed_1664
OrganismMetallosphaera sedula (strain ATCC 51363 / DSM 5348) [Complete proteome] [HAMAP]
Taxonomic identifier399549 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 447447Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000072769

Sequences

Sequence LengthMass (Da)Tools
A4YHB7 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 8CA448B5C336BF80

FASTA44750,941
        10         20         30         40         50         60 
MDNHPWLPNI SRIKDMLREI GVDDVEQLFQ DVPRDLILRR ELKVGYDSPL PEEDIRWRLN 

        70         80         90        100        110        120 
QVAERNLKLR YPPFLGAGAY PHSIPSVIRF ILSRSEFYTA YTPYQPEVNQ GLLQGLFEYQ 

       130        140        150        160        170        180 
SLMAELLEMD VVNSSHYDWG GSLAEAVLMG YRINGKRKVV IPESINPLHE EVLRTWVSGR 

       190        200        210        220        230        240 
ELEVVKIPVG KDGKIDLDFL SSLNSDEISS IYIQQPNFFG VVETELEYVT DWARKNNVVS 

       250        260        270        280        290        300 
IMGVSPLSLG LIKTPGELGF DIAVGDGQEL GIPLNFGGPY SGILATRMDM KLVRQMPGRI 

       310        320        330        340        350        360 
VGMTQDSQGR RGFTLILQTR EQFARREKAT SNITTNEALI ALANAVYLSL LGKEGIRELA 

       370        380        390        400        410        420 
TEIYKRSHYA LKRMEDEELG KRKWESDFFE EFTFVFRSDY DRIHSELLRR GIHGGLRLGP 

       430        440 
REALFCVTEV HTKRAIDDLV NAMKEVA 

« Hide

References

[1]"The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51363 / DSM 5348.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000682 Genomic DNA. Translation: ABP95819.1.
RefSeqYP_001191743.1. NC_009440.1.

3D structure databases

ProteinModelPortalA4YHB7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING399549.Msed_1664.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP95819; ABP95819; Msed_1664.
GeneID5104869.
KEGGmse:Msed_1664.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMASMYDGST.
ProtClustDBPRK00451.

Enzyme and pathway databases

BioCycMSED399549:GH1O-1687-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_METS5
AccessionPrimary (citable) accession number: A4YHB7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 29, 2007
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families