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A4YHA6 (PGK_METS5) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:Msed_1653
OrganismMetallosphaera sedula (strain ATCC 51363 / DSM 5348) [Complete proteome] [HAMAP]
Taxonomic identifier399549 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_1000071472

Regions

Nucleotide binding355 – 3584ATP By similarity
Region21 – 233Substrate binding By similarity
Region61 – 644Substrate binding By similarity

Sites

Binding site381Substrate By similarity
Binding site1181Substrate By similarity
Binding site1581Substrate By similarity
Binding site3291ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A4YHA6 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 4216EEAE19235155

FASTA40744,413
        10         20         30         40         50         60 
MNIPTLDDLN FSNSKVLVRI DINSPVDSKT GKLLDDSRIK AHVETIRELV SRGNGVVLVS 

        70         80         90        100        110        120 
HQGRPGDNDF TDLEEHSRLL QKHLDMEVEF VGDVMGPYAR ERIRNMKLGS VLLLDNVRFV 

       130        140        150        160        170        180 
SEELIEASPL QHSRSFLVRR LQPLFQGYVN DAFATAHRSQ ASLVGFPLVL RSSAGRVMEK 

       190        200        210        220        230        240 
EVSALAKVFN EGEEPKVFIM GGGKVLDSLR IIENLVKRRL ADRILTGGLI AELFAVAKGL 

       250        260        270        280        290        300 
DLGKDNLQVL EKAGVLSLVP RARKLLLSGA PVEIPVDFKV EKGGQVYEEP ANKVTAVIKD 

       310        320        330        340        350        360 
VGSTTVGIYS SFIRDAKIIV MRGPMGVIED ERFRESSRTL LKNSLESPGY LIVGGGHMIS 

       370        380        390        400 
LLGGIGPLDS SKVHVSTGGG ALLLFLAGER LPALEALDIS AREVLKK 

« Hide

References

[1]"The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51363 / DSM 5348.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000682 Genomic DNA. Translation: ABP95808.1.
RefSeqYP_001191732.1. NC_009440.1.

3D structure databases

ProteinModelPortalA4YHA6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING399549.Msed_1653.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP95808; ABP95808; Msed_1653.
GeneID5104858.
KEGGmse:Msed_1653.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227108.
KOK00927.
OMADMIFDIG.
ProtClustDBPRK00073.

Enzyme and pathway databases

BioCycMSED399549:GH1O-1673-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_METS5
AccessionPrimary (citable) accession number: A4YHA6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 29, 2007
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways