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A4YES9

- CAPPA_METS5

UniProt

A4YES9 - CAPPA_METS5

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Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciMSED399549:GH1O-771-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcAUniRule annotation
Ordered Locus Names:Msed_0756
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348)
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
ProteomesiUP000000242: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Phosphoenolpyruvate carboxylasePRO_1000088478Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi399549.Msed_0756.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1892.
HOGENOMiHOG000038601.
KOiK01595.
OMAiKTMSTQH.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YES9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPIPRTMST QHPDNATVPE WAKGDVIEGE AEVIEAYYAF SRLNVHEVMW
60 70 80 90 100
DAEGKDVDTH VVRKLFSSFD EYFKNNILGE DIFLTYRLPN PKIEGAERKV
110 120 130 140 150
FAETMESIPI TFDVAERFYG RKVVPVFEVI LPFTTNASDI ISVARYYERA
160 170 180 190 200
VAMEENIELQ DGVYVRDLVG EIYPKRIEVI PLIEDKDSLL NTRNIIEGYY
210 220 230 240 250
RAIKPSYMRL FIARSDPAMN YGMLTAVLLA KYALSEAGKL AEELGIPIFP
260 270 280 290 300
IIGVGSLPFR GHLSPENYQR VMEEYEGVYT FTIQSAFKYD YSEEQVKGAI
310 320 330 340 350
SHINREEVKE PRILGEEEKK VTRDIIETYT LSYQPVIESL ANLINTVALH
360 370 380 390 400
LPRRRARKLH ISLFGYARST GKVMLPRAIT FVGSLYSVGL PPEVIGISSL
410 420 430 440 450
GKLNEMQWNI LEENYKFLKN DLQKASEFIN PEGLSTLVSY GYLDAEISKK
460 470 480 490 500
LEEDIKYLES MGVKIGPRSY ETKKHALLSQ LLMLSLKEKK YNEVKQYARE

MAVIRKSIG
Length:509
Mass (Da):58,245
Last modified:May 29, 2007 - v1
Checksum:iFCF967A96862D3C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA. Translation: ABP94931.1.
RefSeqiWP_012020718.1. NC_009440.1.
YP_001190855.1. NC_009440.1.

Genome annotation databases

EnsemblBacteriaiABP94931; ABP94931; Msed_0756.
GeneIDi5103445.
KEGGimse:Msed_0756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA. Translation: ABP94931.1 .
RefSeqi WP_012020718.1. NC_009440.1.
YP_001190855.1. NC_009440.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399549.Msed_0756.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP94931 ; ABP94931 ; Msed_0756 .
GeneIDi 5103445.
KEGGi mse:Msed_0756.

Phylogenomic databases

eggNOGi COG1892.
HOGENOMi HOG000038601.
KOi K01595.
OMAi KTMSTQH.

Enzyme and pathway databases

BioCyci MSED399549:GH1O-771-MONOMER.

Family and domain databases

HAMAPi MF_01904. PEPcase_type2.
InterProi IPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF14010. PEPcase_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006677. UCP006677. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR02751. PEPCase_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
    Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
    Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51363 / DSM 5348.

Entry informationi

Entry nameiCAPPA_METS5
AccessioniPrimary (citable) accession number: A4YES9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: November 26, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3