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A4YES9 (CAPPA_METS5) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoenolpyruvate carboxylase

Short name=PEPC
Short name=PEPCase
EC=4.1.1.31
Gene names
Name:ppcA
Ordered Locus Names:Msed_0756
OrganismMetallosphaera sedula (strain ATCC 51363 / DSM 5348) [Complete proteome] [HAMAP]
Taxonomic identifier399549 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity. HAMAP-Rule MF_01904

Catalytic activity

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-. HAMAP-Rule MF_01904

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01904

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_01904

Sequence similarities

Belongs to the PEPCase type 2 family.

Ontologies

Keywords
   Biological processCarbon dioxide fixation
   LigandMagnesium
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcarbon fixation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

oxaloacetate metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tricarboxylic acid cycle

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

phosphoenolpyruvate carboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509Phosphoenolpyruvate carboxylase HAMAP-Rule MF_01904
PRO_1000088478

Sequences

Sequence LengthMass (Da)Tools
A4YES9 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: FCF967A96862D3C5

FASTA50958,245
        10         20         30         40         50         60 
MRPIPRTMST QHPDNATVPE WAKGDVIEGE AEVIEAYYAF SRLNVHEVMW DAEGKDVDTH 

        70         80         90        100        110        120 
VVRKLFSSFD EYFKNNILGE DIFLTYRLPN PKIEGAERKV FAETMESIPI TFDVAERFYG 

       130        140        150        160        170        180 
RKVVPVFEVI LPFTTNASDI ISVARYYERA VAMEENIELQ DGVYVRDLVG EIYPKRIEVI 

       190        200        210        220        230        240 
PLIEDKDSLL NTRNIIEGYY RAIKPSYMRL FIARSDPAMN YGMLTAVLLA KYALSEAGKL 

       250        260        270        280        290        300 
AEELGIPIFP IIGVGSLPFR GHLSPENYQR VMEEYEGVYT FTIQSAFKYD YSEEQVKGAI 

       310        320        330        340        350        360 
SHINREEVKE PRILGEEEKK VTRDIIETYT LSYQPVIESL ANLINTVALH LPRRRARKLH 

       370        380        390        400        410        420 
ISLFGYARST GKVMLPRAIT FVGSLYSVGL PPEVIGISSL GKLNEMQWNI LEENYKFLKN 

       430        440        450        460        470        480 
DLQKASEFIN PEGLSTLVSY GYLDAEISKK LEEDIKYLES MGVKIGPRSY ETKKHALLSQ 

       490        500 
LLMLSLKEKK YNEVKQYARE MAVIRKSIG 

« Hide

References

[1]"The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51363 / DSM 5348.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000682 Genomic DNA. Translation: ABP94931.1.
RefSeqYP_001190855.1. NC_009440.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING399549.Msed_0756.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP94931; ABP94931; Msed_0756.
GeneID5103445.
KEGGmse:Msed_0756.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1892.
HOGENOMHOG000038601.
KOK01595.
OMAQAYREET.
ProtClustDBPRK13655.

Enzyme and pathway databases

BioCycMSED399549:GH1O-771-MONOMER.

Family and domain databases

HAMAPMF_01904. PEPcase_type2.
InterProIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFPIRSF006677. UCP006677. 1 hit.
SUPFAMSSF51621. SSF51621. 1 hit.
TIGRFAMsTIGR02751. PEPCase_arch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCAPPA_METS5
AccessionPrimary (citable) accession number: A4YES9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families