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Protein
Submitted name:

Isocitrate dehydrogenase (NADP)

Gene

Msed_0703

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Enzyme and pathway databases

BioCyciMSED399549:GH1O-717-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase (NADP)Imported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Msed_0703Imported
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348)Imported
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
ProteomesiUP000000242 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi399549.Msed_0703.

Structurei

3D structure databases

ProteinModelPortaliA4YEM6.
SMRiA4YEM6. Positions 24-430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiFRDWGYE.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4YEM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEPLIIQKV KSCSNYLTFM SHVPDDGEKI SFQNGRWIVP NKPVILYIEG
60 70 80 90 100
DGIGPEIVTS ARQVVDKAVE KAYGSKREIK WVEVLAGDKA FAKTGDRFPK
110 120 130 140 150
ETQEMLLNYR VVVKGPLETP IGKGWKSVNV AIRLMLDLYA NIRPVKYIDG
160 170 180 190 200
LESPLKEPNK VDMIIFRENT DDLYRGIEYT YDSEEAKKIR SFLKNELHVD
210 220 230 240 250
VEDDTGIGIK VISKFKTERI TRMAMNYAIE HGRRKLTIMH KGNVLKYTEG
260 270 280 290 300
AFRDWAYDLI KREYRDKVVT EEEIMKDYNG KAPEGKIVVN DRIADNMFQQ
310 320 330 340 350
IITRPDEYDV ILAPNLNGDY ISDAAGALIG NIGMLGGANI GDSGGMFEAI
360 370 380 390 400
HGTAPKYAGK NMANPTGIIK GCELMLRFMG WNEAADLVEK SVLRAVSAKR
410 420 430
VTQDLARFMG VKALSTTEFT KELINIMDTL
Length:430
Mass (Da):48,395
Last modified:May 29, 2007 - v1
Checksum:iC1D3B0A8B288115C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA. Translation: ABP94878.1.
RefSeqiYP_001190802.1. NC_009440.1.

Genome annotation databases

EnsemblBacteriaiABP94878; ABP94878; Msed_0703.
GeneIDi5105309.
KEGGimse:Msed_0703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA. Translation: ABP94878.1.
RefSeqiYP_001190802.1. NC_009440.1.

3D structure databases

ProteinModelPortaliA4YEM6.
SMRiA4YEM6. Positions 24-430.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399549.Msed_0703.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP94878; ABP94878; Msed_0703.
GeneIDi5105309.
KEGGimse:Msed_0703.

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiFRDWGYE.

Enzyme and pathway databases

BioCyciMSED399549:GH1O-717-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
    Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
    Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51363 / DSM 5348Imported.

Entry informationi

Entry nameiA4YEM6_METS5
AccessioniPrimary (citable) accession number: A4YEM6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: April 29, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.