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Protein

Translation initiation factor 2 subunit beta

Gene

eif2b

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciMSED399549:GH1O-672-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit betaUniRule annotation
Alternative name(s):
aIF2-betaUniRule annotation
eIF-2-betaUniRule annotation
Gene namesi
Name:eif2bUniRule annotation
Ordered Locus Names:Msed_0658
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348)
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
ProteomesiUP000000242 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Translation initiation factor 2 subunit betaPRO_0000336756Add
BLAST

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.UniRule annotation

Protein-protein interaction databases

STRINGi399549.Msed_0658.

Structurei

3D structure databases

ProteinModelPortaliA4YEI1.
SMRiA4YEI1. Positions 8-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-2-beta/eIF-5 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01640. Archaea.
COG1601. LUCA.
HOGENOMiHOG000107197.
KOiK03238.
OMAiPVCNSID.

Family and domain databases

Gene3Di3.30.30.50. 1 hit.
HAMAPiMF_00232. eIF_2_beta.
InterProiIPR004458. TIF2_bsu_arc.
IPR002735. Transl_init_fac_IF2/IF5.
IPR016189. Transl_init_fac_IF2/IF5_N.
IPR016190. Transl_init_fac_IF2/IF5_Zn-bd.
[Graphical view]
PfamiPF01873. eIF-5_eIF-2B. 1 hit.
[Graphical view]
SUPFAMiSSF100966. SSF100966. 1 hit.
SSF75689. SSF75689. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YEI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSERDKLYHV LLDRLYAKLP KKDLASETQT LPTLSIINVG NTTIIRNFSE
60 70 80 90 100
YCDRIRREDK ICMRYLLKEL AAAGSISENG QLMIQGKFSN AIVNTFMDRF
110 120 130 140
LKTYVQCSTC KSLDTVLVKD KKIWYIQCLA CGAKNPVKPL
Length:140
Mass (Da):16,030
Last modified:May 29, 2007 - v1
Checksum:iCABC0330B51B4EB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA. Translation: ABP94833.1.
RefSeqiWP_012020620.1. NC_009440.1.

Genome annotation databases

EnsemblBacteriaiABP94833; ABP94833; Msed_0658.
GeneIDi5103818.
KEGGimse:Msed_0658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA. Translation: ABP94833.1.
RefSeqiWP_012020620.1. NC_009440.1.

3D structure databases

ProteinModelPortaliA4YEI1.
SMRiA4YEI1. Positions 8-140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399549.Msed_0658.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP94833; ABP94833; Msed_0658.
GeneIDi5103818.
KEGGimse:Msed_0658.

Phylogenomic databases

eggNOGiarCOG01640. Archaea.
COG1601. LUCA.
HOGENOMiHOG000107197.
KOiK03238.
OMAiPVCNSID.

Enzyme and pathway databases

BioCyciMSED399549:GH1O-672-MONOMER.

Family and domain databases

Gene3Di3.30.30.50. 1 hit.
HAMAPiMF_00232. eIF_2_beta.
InterProiIPR004458. TIF2_bsu_arc.
IPR002735. Transl_init_fac_IF2/IF5.
IPR016189. Transl_init_fac_IF2/IF5_N.
IPR016190. Transl_init_fac_IF2/IF5_Zn-bd.
[Graphical view]
PfamiPF01873. eIF-5_eIF-2B. 1 hit.
[Graphical view]
SUPFAMiSSF100966. SSF100966. 1 hit.
SSF75689. SSF75689. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
    Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
    Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51363 / DSM 5348.

Entry informationi

Entry nameiIF2B_METS5
AccessioniPrimary (citable) accession number: A4YEI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: December 9, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.