A4YEI1 (IF2B_METS5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Translation initiation factor 2 subunit beta

Alternative name(s):
aIF2-beta
eIF-2-beta

Gene names

Name:	eif2b
Ordered Locus Names:	Msed_0658

Organism

Metallosphaera sedula (strain ATCC 51363 / DSM 5348) [Complete proteome] [HAMAP]

Taxonomic identifier

399549 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Metallosphaera › Metallosphaera sedula

Protein attributes

Sequence length	140 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA By similarity. HAMAP-Rule MF_00232
Subunit structure	Heterotrimer composed of an alpha, a beta and a gamma chain By similarity.
Sequence similarities	Belongs to the eIF-2-beta/eIF-5 family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Molecular function	Initiation factor
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	translation initiation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 140	140	Translation initiation factor 2 subunit beta HAMAP-Rule MF_00232		PRO_0000336756

Sequences

	Sequence		Length	Mass (Da)
	A4YEI1 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: CABC0330B51B4EB0	FASTA	140	16,030
	10 20 30 40 50 60 MSERDKLYHV LLDRLYAKLP KKDLASETQT LPTLSIINVG NTTIIRNFSE YCDRIRREDK 70 80 90 100 110 120 ICMRYLLKEL AAAGSISENG QLMIQGKFSN AIVNTFMDRF LKTYVQCSTC KSLDTVLVKD 130 140 KKIWYIQCLA CGAKNPVKPL

References

[1]

"The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism." Auernik K.S., Maezato Y., Blum P.H., Kelly R.M. Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51363 / DSM 5348.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000682 Genomic DNA. Translation: ABP94833.1.
RefSeq	YP_001190757.1. NC_009440.1.
3D structure databases
ProteinModelPortal	A4YEI1.
SMR	A4YEI1. Positions 8-140.
ModBase	Search...
Protein-protein interaction databases
STRING	399549.Msed_0658.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABP94833; ABP94833; Msed_0658.
GeneID	5103818.
KEGG	mse:Msed_0658.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1601.
HOGENOM	HOG000107197.
KO	K03238.
OMA	CNSIDTE.
ProtClustDB	PRK03988.
Enzyme and pathway databases
BioCyc	MSED399549:GH1O-672-MONOMER.
Family and domain databases
Gene3D	3.30.30.50. 1 hit.
HAMAP	MF_00232. eIF-2-beta.
InterPro	IPR004458. TIF2_bsu_arc. IPR002735. Transl_init_fac_IF2/IF5. IPR016189. Transl_init_fac_IF2/IF5_N. IPR016190. Transl_init_fac_IF2/IF5_Zn-bd. [Graphical view]
Pfam	PF01873. eIF-5_eIF-2B. 1 hit. [Graphical view]
SUPFAM	SSF100966. Transl_init_fac_IF2/IF5_N. 1 hit. SSF75689. Transl_init_fac_IF2/IF5_Zn-bd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IF2B_METS5

Accession

Primary (citable) accession number: A4YEI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 29, 2007
Last modified:	May 29, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program