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A4YE96

- SYL1_METS5

UniProt

A4YE96 - SYL1_METS5

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Protein

Leucine--tRNA ligase 1

Gene

leuS1

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei623 – 6231ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSED399549:GH1O-587-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase 1UniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetase 1UniRule annotation
Short name:
LeuRS 1UniRule annotation
Gene namesi
Name:leuS1UniRule annotation
Ordered Locus Names:Msed_0573
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348)
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
ProteomesiUP000000242: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 938938Leucine--tRNA ligase 1PRO_0000334841Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399549.Msed_0573.

Structurei

3D structure databases

ProteinModelPortaliA4YE96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5011"HIGH" regionAdd
BLAST
Motifi620 – 6245"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiQFTGTPI.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YE96-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSAFFNEVA KKWQEKWENN KVFEANPSNS EKYFITVAFP YTNSPLHIGH
60 70 80 90 100
GRTYITADIV ARYQRMIGKN VLFPFAFQFT GTPILSISES IKRGDSDIIS
110 120 130 140 150
DFINLYKISP EKVREFEDPL KLAEYFKEDM KRMAKALGLS VDWRREFTTI
160 170 180 190 200
DPRFGQFIKW QFRKLKEKGF ITTATDAVGY CPNDNFPVGM HDTKGDVEPE
210 220 230 240 250
VQEMDVIEFE GNDVVFPTAT SRPETVFGAN AVLINPEATY VLIRGSNWVL
260 270 280 290 300
SKEAFRKLSY QRELVPEREV QGKDLIGLTV KNPISGKDVK VYGSKFVDAK
310 320 330 340 350
MGTGSVMAVP AHEPLHYLGL SEVLSEVEVI PVISTEGYGD FPGPEVLALA
360 370 380 390 400
GTKNPAELKD YIDTLYREEY YKGVMREDIV DLVPDYMRSI VKDRIAGKRV
410 420 430 440 450
PEARRETVEL LRSLGKHDLI YEISNGPIYC RCGAEIVVKV IRDQWYITYD
460 470 480 490 500
NPLWKSWTMK ALDRISIVPE EARRDMAKAI FSMKRRACSR SRGLGVKLPW
510 520 530 540 550
DESQIIDSLS DSTIYTGFYT VAHKLSHDPS KLNDQFWDFV LLGNGDASEV
560 570 580 590 600
SKVTGISVEE LKDLRNEFSY WYPLDSRHSG RDLVQNHLPF LIYNHLAIFG
610 620 630 640 650
ESLLPRQIVI NGFVRVGGKK MSKSFRNIYP LYKAVEEYGV DPVRLALTIS
660 670 680 690 700
SELLEDTDFD VNTVKAVTDQ LRRMYDLAVN LSKLRENEST GLPEKWLLSI
710 720 730 740 750
IHYKVKEVSD LMNSLDLRKA FNIILYEYYE ILRDYLSMVS NPNTSVLRKA
760 770 780 790 800
IEIWARLISP GAPHIAEEIW HIFNEGFVSL TRYPVPEELE VDGQAVIQLE
810 820 830 840 850
YIRHLINQVK EISSMANKQP EKLIIYVSNS DELGILRAVL RGLKERKNLR
860 870 880 890 900
ELSSITGQRE EYLRSLVERV QSLPPILREL IVTYPLDEFK TITDNLNFLV
910 920 930
RRLDVDEIQV YRSDEANAPD IKGKKSNALP LLPGIVII
Length:938
Mass (Da):107,432
Last modified:May 29, 2007 - v1
Checksum:iFC5DCA901315932E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA. Translation: ABP94748.1.
RefSeqiWP_012020536.1. NC_009440.1.
YP_001190672.1. NC_009440.1.

Genome annotation databases

EnsemblBacteriaiABP94748; ABP94748; Msed_0573.
GeneIDi5103733.
KEGGimse:Msed_0573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA. Translation: ABP94748.1 .
RefSeqi WP_012020536.1. NC_009440.1.
YP_001190672.1. NC_009440.1.

3D structure databases

ProteinModelPortali A4YE96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399549.Msed_0573.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP94748 ; ABP94748 ; Msed_0573 .
GeneIDi 5103733.
KEGGi mse:Msed_0573.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi QFTGTPI.

Enzyme and pathway databases

BioCyci MSED399549:GH1O-587-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
    Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
    Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51363 / DSM 5348.

Entry informationi

Entry nameiSYL1_METS5
AccessioniPrimary (citable) accession number: A4YE96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: November 26, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3