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A4YE96

- SYL1_METS5

UniProt

A4YE96 - SYL1_METS5

Protein

Leucine--tRNA ligase 1

Gene

leuS1

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei623 – 6231ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMSED399549:GH1O-587-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligase 1UniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetase 1UniRule annotation
    Short name:
    LeuRS 1UniRule annotation
    Gene namesi
    Name:leuS1UniRule annotation
    Ordered Locus Names:Msed_0573
    OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348)
    Taxonomic identifieri399549 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
    ProteomesiUP000000242: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 938938Leucine--tRNA ligase 1PRO_0000334841Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi399549.Msed_0573.

    Structurei

    3D structure databases

    ProteinModelPortaliA4YE96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5011"HIGH" regionAdd
    BLAST
    Motifi620 – 6245"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000216620.
    KOiK01869.
    OMAiQFTGTPI.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_A. Leu_tRNA_synth_A.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4YE96-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSAFFNEVA KKWQEKWENN KVFEANPSNS EKYFITVAFP YTNSPLHIGH    50
    GRTYITADIV ARYQRMIGKN VLFPFAFQFT GTPILSISES IKRGDSDIIS 100
    DFINLYKISP EKVREFEDPL KLAEYFKEDM KRMAKALGLS VDWRREFTTI 150
    DPRFGQFIKW QFRKLKEKGF ITTATDAVGY CPNDNFPVGM HDTKGDVEPE 200
    VQEMDVIEFE GNDVVFPTAT SRPETVFGAN AVLINPEATY VLIRGSNWVL 250
    SKEAFRKLSY QRELVPEREV QGKDLIGLTV KNPISGKDVK VYGSKFVDAK 300
    MGTGSVMAVP AHEPLHYLGL SEVLSEVEVI PVISTEGYGD FPGPEVLALA 350
    GTKNPAELKD YIDTLYREEY YKGVMREDIV DLVPDYMRSI VKDRIAGKRV 400
    PEARRETVEL LRSLGKHDLI YEISNGPIYC RCGAEIVVKV IRDQWYITYD 450
    NPLWKSWTMK ALDRISIVPE EARRDMAKAI FSMKRRACSR SRGLGVKLPW 500
    DESQIIDSLS DSTIYTGFYT VAHKLSHDPS KLNDQFWDFV LLGNGDASEV 550
    SKVTGISVEE LKDLRNEFSY WYPLDSRHSG RDLVQNHLPF LIYNHLAIFG 600
    ESLLPRQIVI NGFVRVGGKK MSKSFRNIYP LYKAVEEYGV DPVRLALTIS 650
    SELLEDTDFD VNTVKAVTDQ LRRMYDLAVN LSKLRENEST GLPEKWLLSI 700
    IHYKVKEVSD LMNSLDLRKA FNIILYEYYE ILRDYLSMVS NPNTSVLRKA 750
    IEIWARLISP GAPHIAEEIW HIFNEGFVSL TRYPVPEELE VDGQAVIQLE 800
    YIRHLINQVK EISSMANKQP EKLIIYVSNS DELGILRAVL RGLKERKNLR 850
    ELSSITGQRE EYLRSLVERV QSLPPILREL IVTYPLDEFK TITDNLNFLV 900
    RRLDVDEIQV YRSDEANAPD IKGKKSNALP LLPGIVII 938
    Length:938
    Mass (Da):107,432
    Last modified:May 29, 2007 - v1
    Checksum:iFC5DCA901315932E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000682 Genomic DNA. Translation: ABP94748.1.
    RefSeqiWP_012020536.1. NC_009440.1.
    YP_001190672.1. NC_009440.1.

    Genome annotation databases

    EnsemblBacteriaiABP94748; ABP94748; Msed_0573.
    GeneIDi5103733.
    KEGGimse:Msed_0573.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000682 Genomic DNA. Translation: ABP94748.1 .
    RefSeqi WP_012020536.1. NC_009440.1.
    YP_001190672.1. NC_009440.1.

    3D structure databases

    ProteinModelPortali A4YE96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399549.Msed_0573.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP94748 ; ABP94748 ; Msed_0573 .
    GeneIDi 5103733.
    KEGGi mse:Msed_0573.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000216620.
    KOi K01869.
    OMAi QFTGTPI.

    Enzyme and pathway databases

    BioCyci MSED399549:GH1O-587-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_A. Leu_tRNA_synth_A.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
      Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
      Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51363 / DSM 5348.

    Entry informationi

    Entry nameiSYL1_METS5
    AccessioniPrimary (citable) accession number: A4YE96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3