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A4YE96

- SYL1_METS5

UniProt

A4YE96 - SYL1_METS5

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Protein
Leucine--tRNA ligase 1
Gene
leuS1, Msed_0573
Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei623 – 6231ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSED399549:GH1O-587-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase 1 (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase 1
Short name:
LeuRS 1
Gene namesi
Name:leuS1
Ordered Locus Names:Msed_0573
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348)
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
ProteomesiUP000000242: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 938938Leucine--tRNA ligase 1UniRule annotation
PRO_0000334841Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399549.Msed_0573.

Structurei

3D structure databases

ProteinModelPortaliA4YE96.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5011"HIGH" regionUniRule annotation
Add
BLAST
Motifi620 – 6245"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiQFTGTPI.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YE96-1 [UniParc]FASTAAdd to Basket

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MDSAFFNEVA KKWQEKWENN KVFEANPSNS EKYFITVAFP YTNSPLHIGH    50
GRTYITADIV ARYQRMIGKN VLFPFAFQFT GTPILSISES IKRGDSDIIS 100
DFINLYKISP EKVREFEDPL KLAEYFKEDM KRMAKALGLS VDWRREFTTI 150
DPRFGQFIKW QFRKLKEKGF ITTATDAVGY CPNDNFPVGM HDTKGDVEPE 200
VQEMDVIEFE GNDVVFPTAT SRPETVFGAN AVLINPEATY VLIRGSNWVL 250
SKEAFRKLSY QRELVPEREV QGKDLIGLTV KNPISGKDVK VYGSKFVDAK 300
MGTGSVMAVP AHEPLHYLGL SEVLSEVEVI PVISTEGYGD FPGPEVLALA 350
GTKNPAELKD YIDTLYREEY YKGVMREDIV DLVPDYMRSI VKDRIAGKRV 400
PEARRETVEL LRSLGKHDLI YEISNGPIYC RCGAEIVVKV IRDQWYITYD 450
NPLWKSWTMK ALDRISIVPE EARRDMAKAI FSMKRRACSR SRGLGVKLPW 500
DESQIIDSLS DSTIYTGFYT VAHKLSHDPS KLNDQFWDFV LLGNGDASEV 550
SKVTGISVEE LKDLRNEFSY WYPLDSRHSG RDLVQNHLPF LIYNHLAIFG 600
ESLLPRQIVI NGFVRVGGKK MSKSFRNIYP LYKAVEEYGV DPVRLALTIS 650
SELLEDTDFD VNTVKAVTDQ LRRMYDLAVN LSKLRENEST GLPEKWLLSI 700
IHYKVKEVSD LMNSLDLRKA FNIILYEYYE ILRDYLSMVS NPNTSVLRKA 750
IEIWARLISP GAPHIAEEIW HIFNEGFVSL TRYPVPEELE VDGQAVIQLE 800
YIRHLINQVK EISSMANKQP EKLIIYVSNS DELGILRAVL RGLKERKNLR 850
ELSSITGQRE EYLRSLVERV QSLPPILREL IVTYPLDEFK TITDNLNFLV 900
RRLDVDEIQV YRSDEANAPD IKGKKSNALP LLPGIVII 938
Length:938
Mass (Da):107,432
Last modified:May 29, 2007 - v1
Checksum:iFC5DCA901315932E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000682 Genomic DNA. Translation: ABP94748.1.
RefSeqiWP_012020536.1. NC_009440.1.
YP_001190672.1. NC_009440.1.

Genome annotation databases

EnsemblBacteriaiABP94748; ABP94748; Msed_0573.
GeneIDi5103733.
KEGGimse:Msed_0573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000682 Genomic DNA. Translation: ABP94748.1 .
RefSeqi WP_012020536.1. NC_009440.1.
YP_001190672.1. NC_009440.1.

3D structure databases

ProteinModelPortali A4YE96.
ModBasei Search...

Protein-protein interaction databases

STRINGi 399549.Msed_0573.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP94748 ; ABP94748 ; Msed_0573 .
GeneIDi 5103733.
KEGGi mse:Msed_0573.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi QFTGTPI.

Enzyme and pathway databases

BioCyci MSED399549:GH1O-587-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
    Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
    Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51363 / DSM 5348.

Entry informationi

Entry nameiSYL1_METS5
AccessioniPrimary (citable) accession number: A4YE96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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