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Protein

Acetylornithine aminotransferase

Gene

argD

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Miscellaneous

May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.UniRule annotation

Catalytic activityi

N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationNote: Binds 1 pyridoxal phosphate per subunit.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine aminotransferase (argD), Acetylornithine aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136Pyridoxal phosphate; via carbonyl oxygenUniRule annotation1
Binding sitei139N2-acetyl-L-ornithineUniRule annotation1
Binding sitei299Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00068; UER00109.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine aminotransferaseUniRule annotation (EC:2.6.1.11UniRule annotation)
Short name:
ACOATUniRule annotation
Gene namesi
Name:argDUniRule annotation
Ordered Locus Names:Msed_0275Imported
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)Imported
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
Proteomesi
  • UP000000242 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei271N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi399549.Msed_0275.

Structurei

3D structure databases

ProteinModelPortaliA4YDF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 110Pyridoxal phosphate bindingUniRule annotation2
Regioni242 – 245Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00915. Archaea.
COG0160. LUCA.
HOGENOMiHOG000020206.
KOiK00823.
OMAiQGHCHPE.
OrthoDBiPOG093Z02MC.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_01107. ArgD_aminotrans_3. 1 hit.
InterProiView protein in InterPro
IPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00202. Aminotran_3. 1 hit.
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 2 hits.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiView protein in PROSITE
PS00600. AA_TRANSFER_CLASS_3. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YDF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLASRIIEE DSRYLMQSFS RWYPLVIERA KGSLVYDVDG KEYIDMNAGI
60 70 80 90 100
GVMALGHGNE KIIRAVQEQM NKFFHYSLTD FYYDLAVRVA RKLVSLVGFQ
110 120 130 140 150
GKVFYANSGT ESVEASLKIA RGHTGRQYII GFTNSFHGRT FGSMSFTSSK
160 170 180 190 200
SVQRSAFSPL LPSTLLVPYP DRHNPLCRED CANAVLEYIE DWVLKKIVDP
210 220 230 240 250
NDVAGFLLEP IQGEGGIIVP PREFLQGLQR IARKNGILLI LDEVQTGIGR
260 270 280 290 300
TGKMFAFEHF GVEPDLICLA KALGGGLPLG AVVGRSEVMD LPRGSHANTF
310 320 330 340 350
GGNALALAAA EVVLEEVPGL LGRVNSLGKM IVDILGSTKS RYVEEIRGMG
360 370 380 390 400
LMIGVDLRRD GEPYEEGLEK VLRRSFERGV LAIGAGESVV RLLPPLVIEE
410
ELAQRGSSII REEIDRL
Length:417
Mass (Da):45,922
Last modified:May 29, 2007 - v1
Checksum:i730C52FCAE8261AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA. Translation: ABP94452.1.
RefSeqiWP_011921420.1. NC_009440.1.

Genome annotation databases

EnsemblBacteriaiABP94452; ABP94452; Msed_0275.
GeneIDi5103895.
KEGGimse:Msed_0275.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA4YDF0_METS5
AccessioniPrimary (citable) accession number: A4YDF0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: June 7, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported