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A4YDF0

- A4YDF0_METS5

UniProt

A4YDF0 - A4YDF0_METS5

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Protein

Acetylornithine/acetyl-lysine aminotransferase

Gene

argD

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in both the arginine and lysine biosynthetic pathways.UniRule annotation

Catalytic activityi

N(2)-acetyl-L-lysine + 2-oxoglutarate = N-acetyl-L-aminoadipate semialdehyde + L-glutamate.UniRule annotation
N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

Cofactori

Binds 1 pyridoxal phosphate per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361Pyridoxal phosphate; via carbonyl oxygenUniRule annotation
Binding sitei139 – 1391N2-acetyl-L-ornithineUniRule annotation
Binding sitei299 – 2991Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
  2. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotationImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation, Lysine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciMSED399549:GH1O-289-MONOMER.
UniPathwayiUPA00033; UER00038.
UPA00068; UER00109.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine/acetyl-lysine aminotransferaseUniRule annotation (EC:2.6.1.-UniRule annotation, EC:2.6.1.11UniRule annotation)
Short name:
ACOATUniRule annotation
Gene namesi
Name:argDUniRule annotation
Synonyms:lysJUniRule annotation
Ordered Locus Names:Msed_0275Imported
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348)Imported
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
ProteomesiUP000000242: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei271 – 2711N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi399549.Msed_0275.

Structurei

3D structure databases

ProteinModelPortaliA4YDF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni109 – 1102Pyridoxal phosphate bindingUniRule annotation
Regioni242 – 2454Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0160.
HOGENOMiHOG000020206.
KOiK00823.
OMAiLVSHACF.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_01107. ArgD_aminotrans_3.
InterProiIPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4YDF0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLASRIIEE DSRYLMQSFS RWYPLVIERA KGSLVYDVDG KEYIDMNAGI
60 70 80 90 100
GVMALGHGNE KIIRAVQEQM NKFFHYSLTD FYYDLAVRVA RKLVSLVGFQ
110 120 130 140 150
GKVFYANSGT ESVEASLKIA RGHTGRQYII GFTNSFHGRT FGSMSFTSSK
160 170 180 190 200
SVQRSAFSPL LPSTLLVPYP DRHNPLCRED CANAVLEYIE DWVLKKIVDP
210 220 230 240 250
NDVAGFLLEP IQGEGGIIVP PREFLQGLQR IARKNGILLI LDEVQTGIGR
260 270 280 290 300
TGKMFAFEHF GVEPDLICLA KALGGGLPLG AVVGRSEVMD LPRGSHANTF
310 320 330 340 350
GGNALALAAA EVVLEEVPGL LGRVNSLGKM IVDILGSTKS RYVEEIRGMG
360 370 380 390 400
LMIGVDLRRD GEPYEEGLEK VLRRSFERGV LAIGAGESVV RLLPPLVIEE
410
ELAQRGSSII REEIDRL
Length:417
Mass (Da):45,922
Last modified:May 29, 2007 - v1
Checksum:i730C52FCAE8261AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000682 Genomic DNA. Translation: ABP94452.1.
RefSeqiWP_011921420.1. NC_009440.1.
YP_001190376.1. NC_009440.1.

Genome annotation databases

EnsemblBacteriaiABP94452; ABP94452; Msed_0275.
GeneIDi5103895.
KEGGimse:Msed_0275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000682 Genomic DNA. Translation: ABP94452.1 .
RefSeqi WP_011921420.1. NC_009440.1.
YP_001190376.1. NC_009440.1.

3D structure databases

ProteinModelPortali A4YDF0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399549.Msed_0275.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP94452 ; ABP94452 ; Msed_0275 .
GeneIDi 5103895.
KEGGi mse:Msed_0275.

Phylogenomic databases

eggNOGi COG0160.
HOGENOMi HOG000020206.
KOi K00823.
OMAi LVSHACF.

Enzyme and pathway databases

UniPathwayi UPA00033 ; UER00038 .
UPA00068 ; UER00109 .
BioCyci MSED399549:GH1O-289-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_01107. ArgD_aminotrans_3.
InterProi IPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
    Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
    Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51363 / DSM 5348Imported.

Entry informationi

Entry nameiA4YDF0_METS5
AccessioniPrimary (citable) accession number: A4YDF0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3