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A4YD91 (GSA_METS5) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate-1-semialdehyde 2,1-aminomutase

Short name=GSA
EC=5.4.3.8
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name=GSA-AT
Gene names
Name:hemL
Ordered Locus Names:Msed_0216
OrganismMetallosphaera sedula (strain ATCC 51363 / DSM 5348) [Complete proteome] [HAMAP]
Taxonomic identifier399549 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotoporphyrinogen IX biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutamate-1-semialdehyde 2,1-aminomutase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

transaminase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 417417Glutamate-1-semialdehyde 2,1-aminomutase HAMAP-Rule MF_00375
PRO_0000382396

Amino acid modifications

Modified residue2591N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A4YD91 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 8963A2BC2653D404

FASTA41745,616
        10         20         30         40         50         60 
MSSDLWNKAQ AVFAGGVNSP VRAAVKPFPF YTRSAKGAYL VTEDSRRLID FVLGYGPLIL 

        70         80         90        100        110        120 
GHAHPKVIEA VKDQLERGWL YGTPSRAEVE LASMITKHVP SAQKVRFVNS GTEATMTALR 

       130        140        150        160        170        180 
LSRGFTGRSK ILKFDGNYHG AHDYVLIDAG SAASEFGVPF SQGIPTEVSS TVLVCPYNDL 

       190        200        210        220        230        240 
TCVETVLKRE EIAGVIVEPV MGNMGVIPPE KDFLPGLRKL TREYGSVLIF DEVITGFRLG 

       250        260        270        280        290        300 
LGGAQSYFGV TPDLTTLGKI IGGGFPIGAV CGRKEIMDQL TPSGRVFNAG TFNANPISMT 

       310        320        330        340        350        360 
AGIATIQELE KKEVYTVSER AARVLAEEID RAIKMDHVVN RVYNFFQFFL GVKDVRNAND 

       370        380        390        400        410 
ARKAKRDLYV KVHESLLKEG VFIPPSQFEA LFTSGAHDDD VVNESARVFK KVLEDLT 

« Hide

References

[1]"The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism."
Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.
Appl. Environ. Microbiol. 74:682-692(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51363 / DSM 5348.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000682 Genomic DNA. Translation: ABP94393.1.
RefSeqYP_001190317.1. NC_009440.1.

3D structure databases

ProteinModelPortalA4YD91.
SMRA4YD91. Positions 1-417.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING399549.Msed_0216.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP94393; ABP94393; Msed_0216.
GeneID5104082.
KEGGmse:Msed_0216.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0001.
HOGENOMHOG000020210.
KOK01845.
OMAPGFKPDI.
ProtClustDBPRK00062.

Enzyme and pathway databases

BioCycMSED399549:GH1O-229-MONOMER.
UniPathwayUPA00251; UER00317.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPMF_00375. HemL_aminotrans_3.
InterProIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR11986. PTHR11986. 1 hit.
PfamPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR00713. hemL. 1 hit.
PROSITEPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSA_METS5
AccessionPrimary (citable) accession number: A4YD91
Entry history
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 29, 2007
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways