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Protein

DNA ligase

Gene

lig

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei259ATPUniRule annotation1
Active sitei261N6-AMP-lysine intermediateUniRule annotation1
Binding sitei266ATPUniRule annotation1
Binding sitei281ATPUniRule annotation1
Binding sitei311ATPUniRule annotation1
Binding sitei351ATPUniRule annotation1
Binding sitei428ATPUniRule annotation1
Binding sitei434ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Msed_0150
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
Proteomesi
  • UP000000242 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000722711 – 598DNA ligaseAdd BLAST598

Interactioni

Protein-protein interaction databases

STRINGi399549.Msed_0150

Structurei

3D structure databases

ProteinModelPortaliA4YD25
SMRiA4YD25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWIKYKRD
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

A4YD25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFKLIAEYF DRLEKISSRI QLTSLLSDLF KNTEREVIDK VVYLIQGRLW
60 70 80 90 100
PDFTGMPEIG MGEKFLIKAI AMAYGNKEEE VEKLYKNIGD LGEVAYSLRS
110 120 130 140 150
KVKGVSILSF VGGNQEAGEL DVMEVYNELV KIATSTGEGS RDIKIRIFAG
160 170 180 190 200
LIKKATPIEA KYLVRFVEGR LRLGIGDATV LDALAITFGG SADYRPIVER
210 220 230 240 250
AYNLRADLGD IARVIATEGI EKLKNISPTP GIPIRPMLAE RLPDPEEIME
260 270 280 290 300
KMNGKALVDY KYDGERAQIH RKGDKVTIFS RRMENITDQY IDVTEYVKQF
310 320 330 340 350
VKGDNFIVEG EIVPVDPESG EMRPFQELMH RRRKNNIAEA IKEYPVNLFL
360 370 380 390 400
FDLMFFEGED YTTKPLPERR AKLEEILASN DKVHIASHII ADRVDKLREY
410 420 430 440 450
FYQAISEGAE GVMVKSIGPD SIYQAGSRGW LWIKLKRDYQ SEMADTVDLV
460 470 480 490 500
VVGAFYGKGK RGGKFSSLLM AAYNPEKDVF ETVCKVASGF SDQELDEMQK
510 520 530 540 550
KINELKREQK HPRVVSDMIP DVWVSPTLVA EVIGAEITIS PLHTCCRGEK
560 570 580 590
GGLSIRFPRF IRWRDDKSPE DATTNQEIME MYSKQLKKIE EKPVDENI
Length:598
Mass (Da):67,922
Last modified:May 29, 2007 - v1
Checksum:iA9C70DF05DA44BB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA Translation: ABP94327.1
RefSeqiWP_011921295.1, NC_009440.1

Genome annotation databases

EnsemblBacteriaiABP94327; ABP94327; Msed_0150
GeneIDi5105003
KEGGimse:Msed_0150

Similar proteinsi

Entry informationi

Entry nameiDNLI_METS5
AccessioniPrimary (citable) accession number: A4YD25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 29, 2007
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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