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Protein

Argininosuccinate synthase

Gene

argG

Organism
Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei96CitrullineUniRule annotation1
Binding sitei101CitrullineUniRule annotation1
Binding sitei126ATP; via amide nitrogenUniRule annotation1
Binding sitei128AspartateUniRule annotation1
Binding sitei132AspartateUniRule annotation1
Binding sitei132CitrullineUniRule annotation1
Binding sitei133AspartateUniRule annotation1
Binding sitei136CitrullineUniRule annotation1
Binding sitei185CitrullineUniRule annotation1
Binding sitei194CitrullineUniRule annotation1
Binding sitei270CitrullineUniRule annotation1
Binding sitei282CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 24ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPUT319224:G1G8R-3887-MONOMER
UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Sputcn32_3714
OrganismiShewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Taxonomic identifieri319224 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000006699 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000004341 – 407Argininosuccinate synthaseAdd BLAST407

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi319224.Sputcn32_3714

Structurei

3D structure databases

ProteinModelPortaliA4YBT9
SMRiA4YBT9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230093
KOiK01940
OMAiGVGRIDM
OrthoDBiPOG091H01U0

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 2 hits
3.90.1260.10, 2 hits
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

A4YBT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIENKNTGV KKVVLAYSGG LDTSAIIPWL KENYDNCEII AFCADVGQGE
60 70 80 90 100
EELVGLTEKA LASGASECHI VDLKEEFVKD YIYPTMATGA IYEGTYLLGT
110 120 130 140 150
SMARPIIAKA QVEVARKVGA DALCHGCTGK GNDQVRFEGC FAALAPDLKV
160 170 180 190 200
IAPWREWTMQ SREDLLDYLA ERNIKTSASA TKIYSRDANA FHISHEGGEL
210 220 230 240 250
EDPWNEPSKG VWTLTADPED APNQPEYVSL EVENGRVTKV NGEALTPYAA
260 270 280 290 300
LMKLNAIAAP HGVGRIDITE NRLVGMKSRG CYETPGGTVM FAALRAIEEL
310 320 330 340 350
VLDKTSRTWR EQVGAQMAHL VYDGRWFTPL CKSLLAASES LAESVNGEVV
360 370 380 390 400
VKLYKGHAIA VKKRSPNSLY SEAFATFGED QVYDQKHAEG FIRLYSLASR

IRALNAK
Length:407
Mass (Da):44,582
Last modified:May 29, 2007 - v1
Checksum:iDE3E33F711E184A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000681 Genomic DNA Translation: ABP77422.1
RefSeqiWP_011920200.1, NC_009438.1

Genome annotation databases

EnsemblBacteriaiABP77422; ABP77422; Sputcn32_3714
KEGGispc:Sputcn32_3714

Similar proteinsi

Entry informationi

Entry nameiASSY_SHEPC
AccessioniPrimary (citable) accession number: A4YBT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: April 25, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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