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A4YAP3

- FTHS_SHEPC

UniProt

A4YAP3 - FTHS_SHEPC

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPUT319224:GHAP-3423-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Sputcn32_3314
OrganismiShewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Taxonomic identifieri319224 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000006699: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Formate--tetrahydrofolate ligasePRO_1000068795Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi319224.Sputcn32_3314.

Structurei

3D structure databases

ProteinModelPortaliA4YAP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4YAP3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTDMEISSR ASLTNVAELG AELGLLPEEM LLFGSTKAKV DLSVQQRLAG
60 70 80 90 100
QSRGKLIIVT AVTPTPHGEG KTVTSIGLTQ SLKAIGKKAC ACIRQPSMGP
110 120 130 140 150
VFGVKGGAAG GGYAQVVPMQ ELNLHLTGDI HAVSSAHNLG AAAIAARLFH
160 170 180 190 200
ESRLGKVEFE AQSGQAFLDI DPAQIRWHRV LDHNDRCLRQ VQVGLGENNG
210 220 230 240 250
PVYESGFDIT AASELMAILA LSANLADMRA RIGRLVLALN RQGQVISAED
260 270 280 290 300
LGVAGAMTAI MVDAIKPTLM QTLNGAPCLI HAGPFANIAH GNSSIIADDI
310 320 330 340 350
ALKLVDYVIT EGGFGSDMGF EKFCNIKVRQ SGQVPSAAVL VTTLKALKAN
360 370 380 390 400
SGIESDTDIN TPDEIRLEAG FANLHWHINN VARYGIPVVV AINRFATDTE
410 420 430 440 450
AELQWLINAV NQTAAFGCEV SDAFSQGEAG AIELAHTVVR AADTQSQFRL
460 470 480 490 500
LYPDDASLEA KLSTLAEVGY GAAGISLSDE AKQQVREFTS LGYAHLPVCM
510 520 530 540 550
AKTPLSISHD PIQKGVPKDF IVPIRALVLN AGAGFVTALV GNVMTMPGLG
560 570
IKPGYLKIDI DEAGEIIGLG
Length:570
Mass (Da):60,067
Last modified:May 29, 2007 - v1
Checksum:iCDC0470D8964E0B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000681 Genomic DNA. Translation: ABP77026.1.
RefSeqiYP_001184825.1. NC_009438.1.

Genome annotation databases

EnsemblBacteriaiABP77026; ABP77026; Sputcn32_3314.
GeneIDi5078089.
KEGGispc:Sputcn32_3314.
PATRICi23555676. VBIShePut135485_3467.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000681 Genomic DNA. Translation: ABP77026.1 .
RefSeqi YP_001184825.1. NC_009438.1.

3D structure databases

ProteinModelPortali A4YAP3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 319224.Sputcn32_3314.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP77026 ; ABP77026 ; Sputcn32_3314 .
GeneIDi 5078089.
KEGGi spc:Sputcn32_3314.
PATRICi 23555676. VBIShePut135485_3467.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SPUT319224:GHAP-3423-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CN-32 / ATCC BAA-453.

Entry informationi

Entry nameiFTHS_SHEPC
AccessioniPrimary (citable) accession number: A4YAP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3