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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Sputcn32_3314
OrganismiShewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Taxonomic identifieri319224 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000006699 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000687951 – 570Formate--tetrahydrofolate ligaseAdd BLAST570

Proteomic databases

PRIDEiA4YAP3

Interactioni

Protein-protein interaction databases

STRINGi319224.Sputcn32_3314

Structurei

3D structure databases

ProteinModelPortaliA4YAP3
SMRiA4YAP3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU Bacteria
COG2759 LUCA
HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM
OrthoDBiPOG091H01S8

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit

Sequencei

Sequence statusi: Complete.

A4YAP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTDMEISSR ASLTNVAELG AELGLLPEEM LLFGSTKAKV DLSVQQRLAG
60 70 80 90 100
QSRGKLIIVT AVTPTPHGEG KTVTSIGLTQ SLKAIGKKAC ACIRQPSMGP
110 120 130 140 150
VFGVKGGAAG GGYAQVVPMQ ELNLHLTGDI HAVSSAHNLG AAAIAARLFH
160 170 180 190 200
ESRLGKVEFE AQSGQAFLDI DPAQIRWHRV LDHNDRCLRQ VQVGLGENNG
210 220 230 240 250
PVYESGFDIT AASELMAILA LSANLADMRA RIGRLVLALN RQGQVISAED
260 270 280 290 300
LGVAGAMTAI MVDAIKPTLM QTLNGAPCLI HAGPFANIAH GNSSIIADDI
310 320 330 340 350
ALKLVDYVIT EGGFGSDMGF EKFCNIKVRQ SGQVPSAAVL VTTLKALKAN
360 370 380 390 400
SGIESDTDIN TPDEIRLEAG FANLHWHINN VARYGIPVVV AINRFATDTE
410 420 430 440 450
AELQWLINAV NQTAAFGCEV SDAFSQGEAG AIELAHTVVR AADTQSQFRL
460 470 480 490 500
LYPDDASLEA KLSTLAEVGY GAAGISLSDE AKQQVREFTS LGYAHLPVCM
510 520 530 540 550
AKTPLSISHD PIQKGVPKDF IVPIRALVLN AGAGFVTALV GNVMTMPGLG
560 570
IKPGYLKIDI DEAGEIIGLG
Length:570
Mass (Da):60,067
Last modified:May 29, 2007 - v1
Checksum:iCDC0470D8964E0B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000681 Genomic DNA Translation: ABP77026.1
RefSeqiWP_011920004.1, NC_009438.1

Genome annotation databases

EnsemblBacteriaiABP77026; ABP77026; Sputcn32_3314
KEGGispc:Sputcn32_3314

Similar proteinsi

Entry informationi

Entry nameiFTHS_SHEPC
AccessioniPrimary (citable) accession number: A4YAP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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