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A4YAD8 (GCSP_SHEPC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Sputcn32_3209
OrganismShewanella putrefaciens (strain CN-32 / ATCC BAA-453) [Complete proteome] [HAMAP]
Taxonomic identifier319224 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length962 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 962962Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045611

Amino acid modifications

Modified residue7091N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A4YAD8 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: E10DF94E0B28DCBD

FASTA962104,568
        10         20         30         40         50         60 
MTKQTLTQLE QHDLFLRRHI GPDSSQQQAM LNYVGAESLD DLTAQIVPES IRLSQELSIG 

        70         80         90        100        110        120 
DSCGEAEGIA YIRGLAKQNQ VFKSYIGMGY YGTQVPNVIL RNVLENPGWY TAYTPYQPEI 

       130        140        150        160        170        180 
AQGRLEAILN FQQVSMDLTG LDLASASLLD EATAAAEAMA LAKRVSKAKK ANIFFVADDV 

       190        200        210        220        230        240 
FPQTLDVVKT RAECFGFEVV VGPASEAVNH ELFGALFQYT NRFGQITDFT ELFAELRAKN 

       250        260        270        280        290        300 
VIVTVAADIM SLVLLKSPGA MGADVVFGSA QRFGVPMGFG GPHAAFFVAR DEHKRSMPGR 

       310        320        330        340        350        360 
IIGVSKDARG NRALRMAMQT REQHIRREKA NSNICTAQIL LANMASFYAV FHGPDGLKTI 

       370        380        390        400        410        420 
ASRIHRFADI LAAGLQAKGV SLVNSTWFDT LSIKGLDVAA VNARALAAEM NLRFDADGTV 

       430        440        450        460        470        480 
GVSLDETTLR TDIDALFDVI LGAGHGLDVA ALDAQIVAQG SQSIPAALVR QDAILSHPTF 

       490        500        510        520        530        540 
NRYQSETEMM RYIKRLESKD LALNYSMISL GSCTMKLNAA VEMIPVSWPE FANMHPFCPL 

       550        560        570        580        590        600 
DQAKGYTQLI EELSSWLVNV TGYDAVCIQP NSGAQGEYAG LLAIKKYHES RGDAHRNICL 

       610        620        630        640        650        660 
IPQSAHGTNP ASAQLAGMQV VVTACDKQGN VDLEDLKTKA AEVAENLSCI MITYPSTHGV 

       670        680        690        700        710        720 
YEESIREICD IVHQHGGQVY LDGANMNAQV GLTSPGFIGA DVSHLNLHKT FAIPHGGGGP 

       730        740        750        760        770        780 
GMGPIGVKSH LAPFVAGHVV VKPGRVSDNN GAVSAAPYGS AGILPISWMY IKLLGSNGLK 

       790        800        810        820        830        840 
KSTQTALLNA NYVMKKLSEH YPVLFRGRND RVAHECIIDL RPLKEASGVT EMDIAKRLND 

       850        860        870        880        890        900 
YGFHAPTMSF PVAGTLMIEP TESESKVELD RFIDAMVSIR AEIAKVESGE WPADNNPLHN 

       910        920        930        940        950        960 
APHTMADIMD PEFDTRPYSR EVAVFPSAAV RTNKFWPTVN RIDDVYGDRN LMCSCAPLSD 


YE 

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References

[1]"Complete sequence of Shewanella putrefaciens CN-32."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Romine M.F., Fredrickson J., Tiedje J., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CN-32 / ATCC BAA-453.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000681 Genomic DNA. Translation: ABP76921.1.
RefSeqYP_001184720.1. NC_009438.1.

3D structure databases

ProteinModelPortalA4YAD8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING319224.Sputcn32_3209.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP76921; ABP76921; Sputcn32_3209.
GeneID5080152.
KEGGspc:Sputcn32_3209.
PATRIC23555452. VBIShePut135485_3359.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycSPUT319224:GHAP-3314-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_SHEPC
AccessionPrimary (citable) accession number: A4YAD8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families