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A4YAD8

- GCSP_SHEPC

UniProt

A4YAD8 - GCSP_SHEPC

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, Sputcn32_3209
Organism
Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSPUT319224:GHAP-3314-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Sputcn32_3209
OrganismiShewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Taxonomic identifieri319224 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000006699: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000045611Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi319224.Sputcn32_3209.

Structurei

3D structure databases

ProteinModelPortaliA4YAD8.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A4YAD8-1 [UniParc]FASTAAdd to Basket

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MTKQTLTQLE QHDLFLRRHI GPDSSQQQAM LNYVGAESLD DLTAQIVPES    50
IRLSQELSIG DSCGEAEGIA YIRGLAKQNQ VFKSYIGMGY YGTQVPNVIL 100
RNVLENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASASLLD 150
EATAAAEAMA LAKRVSKAKK ANIFFVADDV FPQTLDVVKT RAECFGFEVV 200
VGPASEAVNH ELFGALFQYT NRFGQITDFT ELFAELRAKN VIVTVAADIM 250
SLVLLKSPGA MGADVVFGSA QRFGVPMGFG GPHAAFFVAR DEHKRSMPGR 300
IIGVSKDARG NRALRMAMQT REQHIRREKA NSNICTAQIL LANMASFYAV 350
FHGPDGLKTI ASRIHRFADI LAAGLQAKGV SLVNSTWFDT LSIKGLDVAA 400
VNARALAAEM NLRFDADGTV GVSLDETTLR TDIDALFDVI LGAGHGLDVA 450
ALDAQIVAQG SQSIPAALVR QDAILSHPTF NRYQSETEMM RYIKRLESKD 500
LALNYSMISL GSCTMKLNAA VEMIPVSWPE FANMHPFCPL DQAKGYTQLI 550
EELSSWLVNV TGYDAVCIQP NSGAQGEYAG LLAIKKYHES RGDAHRNICL 600
IPQSAHGTNP ASAQLAGMQV VVTACDKQGN VDLEDLKTKA AEVAENLSCI 650
MITYPSTHGV YEESIREICD IVHQHGGQVY LDGANMNAQV GLTSPGFIGA 700
DVSHLNLHKT FAIPHGGGGP GMGPIGVKSH LAPFVAGHVV VKPGRVSDNN 750
GAVSAAPYGS AGILPISWMY IKLLGSNGLK KSTQTALLNA NYVMKKLSEH 800
YPVLFRGRND RVAHECIIDL RPLKEASGVT EMDIAKRLND YGFHAPTMSF 850
PVAGTLMIEP TESESKVELD RFIDAMVSIR AEIAKVESGE WPADNNPLHN 900
APHTMADIMD PEFDTRPYSR EVAVFPSAAV RTNKFWPTVN RIDDVYGDRN 950
LMCSCAPLSD YE 962
Length:962
Mass (Da):104,568
Last modified:May 29, 2007 - v1
Checksum:iE10DF94E0B28DCBD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000681 Genomic DNA. Translation: ABP76921.1.
RefSeqiYP_001184720.1. NC_009438.1.

Genome annotation databases

EnsemblBacteriaiABP76921; ABP76921; Sputcn32_3209.
GeneIDi5080152.
KEGGispc:Sputcn32_3209.
PATRICi23555452. VBIShePut135485_3359.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000681 Genomic DNA. Translation: ABP76921.1 .
RefSeqi YP_001184720.1. NC_009438.1.

3D structure databases

ProteinModelPortali A4YAD8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 319224.Sputcn32_3209.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP76921 ; ABP76921 ; Sputcn32_3209 .
GeneIDi 5080152.
KEGGi spc:Sputcn32_3209.
PATRICi 23555452. VBIShePut135485_3359.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SPUT319224:GHAP-3314-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CN-32 / ATCC BAA-453.

Entry informationi

Entry nameiGCSP_SHEPC
AccessioniPrimary (citable) accession number: A4YAD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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