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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Sputcn32_3209
OrganismiShewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Taxonomic identifieri319224 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000006699 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000456111 – 962Glycine dehydrogenase (decarboxylating)Add BLAST962

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei709N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi319224.Sputcn32_3209

Structurei

3D structure databases

ProteinModelPortaliA4YAD8
SMRiA4YAD8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
KOiK00281
OMAiQTMVCDL
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

A4YAD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKQTLTQLE QHDLFLRRHI GPDSSQQQAM LNYVGAESLD DLTAQIVPES
60 70 80 90 100
IRLSQELSIG DSCGEAEGIA YIRGLAKQNQ VFKSYIGMGY YGTQVPNVIL
110 120 130 140 150
RNVLENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASASLLD
160 170 180 190 200
EATAAAEAMA LAKRVSKAKK ANIFFVADDV FPQTLDVVKT RAECFGFEVV
210 220 230 240 250
VGPASEAVNH ELFGALFQYT NRFGQITDFT ELFAELRAKN VIVTVAADIM
260 270 280 290 300
SLVLLKSPGA MGADVVFGSA QRFGVPMGFG GPHAAFFVAR DEHKRSMPGR
310 320 330 340 350
IIGVSKDARG NRALRMAMQT REQHIRREKA NSNICTAQIL LANMASFYAV
360 370 380 390 400
FHGPDGLKTI ASRIHRFADI LAAGLQAKGV SLVNSTWFDT LSIKGLDVAA
410 420 430 440 450
VNARALAAEM NLRFDADGTV GVSLDETTLR TDIDALFDVI LGAGHGLDVA
460 470 480 490 500
ALDAQIVAQG SQSIPAALVR QDAILSHPTF NRYQSETEMM RYIKRLESKD
510 520 530 540 550
LALNYSMISL GSCTMKLNAA VEMIPVSWPE FANMHPFCPL DQAKGYTQLI
560 570 580 590 600
EELSSWLVNV TGYDAVCIQP NSGAQGEYAG LLAIKKYHES RGDAHRNICL
610 620 630 640 650
IPQSAHGTNP ASAQLAGMQV VVTACDKQGN VDLEDLKTKA AEVAENLSCI
660 670 680 690 700
MITYPSTHGV YEESIREICD IVHQHGGQVY LDGANMNAQV GLTSPGFIGA
710 720 730 740 750
DVSHLNLHKT FAIPHGGGGP GMGPIGVKSH LAPFVAGHVV VKPGRVSDNN
760 770 780 790 800
GAVSAAPYGS AGILPISWMY IKLLGSNGLK KSTQTALLNA NYVMKKLSEH
810 820 830 840 850
YPVLFRGRND RVAHECIIDL RPLKEASGVT EMDIAKRLND YGFHAPTMSF
860 870 880 890 900
PVAGTLMIEP TESESKVELD RFIDAMVSIR AEIAKVESGE WPADNNPLHN
910 920 930 940 950
APHTMADIMD PEFDTRPYSR EVAVFPSAAV RTNKFWPTVN RIDDVYGDRN
960
LMCSCAPLSD YE
Length:962
Mass (Da):104,568
Last modified:May 29, 2007 - v1
Checksum:iE10DF94E0B28DCBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000681 Genomic DNA Translation: ABP76921.1
RefSeqiWP_011788113.1, NC_009438.1

Genome annotation databases

EnsemblBacteriaiABP76921; ABP76921; Sputcn32_3209
KEGGispc:Sputcn32_3209

Similar proteinsi

Entry informationi

Entry nameiGCSP_SHEPC
AccessioniPrimary (citable) accession number: A4YAD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: April 25, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health