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Protein

Adenylyl-sulfate kinase

Gene

cysC

Organism
Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of activated sulfate.UniRule annotation

Catalytic activityi

ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate.UniRule annotation

Pathwayi: hydrogen sulfide biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes sulfite from sulfate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Sulfate adenylyltransferase subunit 1 (cysN), Sulfate adenylyltransferase subunit 2 (cysD)
  2. Adenylyl-sulfate kinase (cysC)
  3. Phosphoadenosine phosphosulfate reductase (cysH)
This subpathway is part of the pathway hydrogen sulfide biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sulfite from sulfate, the pathway hydrogen sulfide biosynthesis and in Sulfur metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei105Phosphoserine intermediateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 38ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00140; UER00205

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylyl-sulfate kinaseUniRule annotation (EC:2.7.1.25UniRule annotation)
Alternative name(s):
APS kinaseUniRule annotation
ATP adenosine-5'-phosphosulfate 3'-phosphotransferaseUniRule annotation
Adenosine-5'-phosphosulfate kinaseUniRule annotation
Gene namesi
Name:cysCUniRule annotation
Ordered Locus Names:Sputcn32_3040
OrganismiShewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Taxonomic identifieri319224 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000006699 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000090261 – 205Adenylyl-sulfate kinaseAdd BLAST205

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi319224.Sputcn32_3040

Structurei

3D structure databases

ProteinModelPortaliA4Y9X0
SMRiA4Y9X0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the APS kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107UCJ Bacteria
COG0529 LUCA
HOGENOMiHOG000228204
KOiK00860
OMAiVSPFRAD
OrthoDBiPOG091H04O4

Family and domain databases

CDDicd02027 APSK, 1 hit
HAMAPiMF_00065 Adenylyl_sulf_kinase, 1 hit
InterProiView protein in InterPro
IPR002891 APS_kinase
IPR027417 P-loop_NTPase
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00455 apsK, 1 hit

Sequencei

Sequence statusi: Complete.

A4Y9X0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNIVWHQHP VDQAARAEQK GQNPVLLWFT GLSGAGKSTL AGALERALFE
60 70 80 90 100
AGFHTYLLDG DNVRHGLCKD LGFTVEDRDE NLRRVGEVAK LMVDAGLVVL
110 120 130 140 150
SAFISPTREE RDGIRARFPA GQFIEVHVST PLSVCEQRDP KGLYVKARSG
160 170 180 190 200
EISNFTGISS PYEAPLAAEL TIDTSKGDLA TQVRALIDYL TAINVINTDK

TKTVA
Length:205
Mass (Da):22,336
Last modified:May 29, 2007 - v1
Checksum:i6FF455C143208C3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000681 Genomic DNA Translation: ABP76753.1
RefSeqiWP_011788282.1, NC_009438.1

Genome annotation databases

EnsemblBacteriaiABP76753; ABP76753; Sputcn32_3040
KEGGispc:Sputcn32_3040

Similar proteinsi

Entry informationi

Entry nameiCYSC_SHEPC
AccessioniPrimary (citable) accession number: A4Y9X0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: April 25, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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