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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei621ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPUT319224:G1G8R-3001-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Sputcn32_2863
OrganismiShewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Taxonomic identifieri319224 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000006699 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000094251 – 859Leucine--tRNA ligaseAdd BLAST859

Proteomic databases

PRIDEiA4Y9E9

Interactioni

Protein-protein interaction databases

STRINGi319224.Sputcn32_2863

Structurei

3D structure databases

ProteinModelPortaliA4Y9E9
SMRiA4Y9E9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi618 – 622"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A4Y9E9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEQYNPSEI EALVQKHWHD NKTFEVTEDA NKEKFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VVARFQRLQG KNVLQPIGWD SFGLPAENAA INNKTAPAPW
110 120 130 140 150
TYENIEYMKN QLKLLGFGYD WSREIATCTP EYYRWEQWFF TKLYEKGLVY
160 170 180 190 200
KKTASVNWCP NDETVLANEQ VQDGCCWRCD TPVEQKEIPQ WFIKITAYAE
210 220 230 240 250
ELLNDIDTLD GWPEQVKTMQ RNWIGRSEGV EMTFGVAGHD KTFDIYTTRP
260 270 280 290 300
DTLMGVTYVA IAAGHPLAEI AAQTNPELAA FIDECKNSTT SEAELATMEK
310 320 330 340 350
RGVATGLFAI HPITGKQVPI WAANFVLMNY GTGAVMSVPG HDQRDFEFAK
360 370 380 390 400
KYGLAIEAVI KPVDGDVDIS EAAYTEKGIL FNSGEFDGLD FEAGFNAIAN
410 420 430 440 450
KLVAEGKGKR QVNYRLRDWG VSRQRYWGAP IPMVTLADGT VIPTPADQLP
460 470 480 490 500
VLLPEDVVMD GIQSPIKADK EWAKTQVNGQ DALRETDTFD TFMESSWYYA
510 520 530 540 550
RYCSPQADEM LDPAKANYWL PVDQYIGGIE HACMHLLYFR FFHKLLRDAG
560 570 580 590 600
LVNSNEPAKQ LLTQGMVLAD AFYYINEKGA RVWVSPLDVA TTEKDDKGRI
610 620 630 640 650
TKAIDKDGNE LVYTGMCKMS KSKNNGIDPQ VMVEKYGADT VRLFMMFASP
660 670 680 690 700
PELTLEWQES GVEGAHRFIK RLWKLASEYI AQDNSEALDV SKLTSEQKAL
710 720 730 740 750
RREVHKTIAK VTDDIGRRQM FNTAVAAVME LMNHLQKAPQ TTGQDRAIIG
760 770 780 790 800
EALSAVMRLL YPIIPHVSFT LWNDLGNTGS IEDSQWPVVD ESALVEDSKL
810 820 830 840 850
IVVQVNGKVR AKITVAADAD KDSVEALGMN DEHVIKYLDG LTVRKVIYVP

GKLLSIVAN
Length:859
Mass (Da):96,692
Last modified:May 29, 2007 - v1
Checksum:iE8B31191708B17F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000681 Genomic DNA Translation: ABP76582.1
RefSeqiWP_011919759.1, NC_009438.1

Genome annotation databases

EnsemblBacteriaiABP76582; ABP76582; Sputcn32_2863
KEGGispc:Sputcn32_2863

Similar proteinsi

Entry informationi

Entry nameiSYL_SHEPC
AccessioniPrimary (citable) accession number: A4Y9E9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: April 25, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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