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Protein

Protein-L-isoaspartate O-methyltransferase

Gene

pcm

Organism
Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei62UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferaseUniRule annotation (EC:2.1.1.77UniRule annotation)
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferaseUniRule annotation
Protein L-isoaspartyl methyltransferaseUniRule annotation
Protein-beta-aspartate methyltransferaseUniRule annotation
Short name:
PIMTUniRule annotation
Gene namesi
Name:pcmUniRule annotation
Ordered Locus Names:Sputcn32_2751
OrganismiShewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Taxonomic identifieri319224 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000006699 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000932881 – 211Protein-L-isoaspartate O-methyltransferaseAdd BLAST211

Interactioni

Protein-protein interaction databases

STRINGi319224.Sputcn32_2751

Structurei

3D structure databases

ProteinModelPortaliA4Y937
SMRiA4Y937
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E26 Bacteria
COG2518 LUCA
HOGENOMiHOG000257189
KOiK00573
OMAiPYTVAFQ
OrthoDBiPOG091H06AY

Family and domain databases

HAMAPiMF_00090 PIMT, 1 hit
InterProiView protein in InterPro
IPR000682 PCMT
IPR029063 SAM-dependent_MTases
PANTHERiPTHR11579 PTHR11579, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00080 pimt, 1 hit
PROSITEiView protein in PROSITE
PS01279 PCMT, 1 hit

Sequencei

Sequence statusi: Complete.

A4Y937-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRVALTSAV NLAKKLSDAG IRNQAVLKAI SQTPREMFLD NALAHKAYEN
60 70 80 90 100
TALPIGQGQT ISQPYIVARM TELLLSNMPK KVLEVGTGSG YQAAILAQLV
110 120 130 140 150
PELCTIERIK GLQIQARQRL KRLDLHNVSF KYGDGWQGWS NRSPFDAIMV
160 170 180 190 200
TAAAATVPEA LLSQLVDGGV LVLPVGENTQ QLMRITRHRE RFSSENIETV
210
KFVPLVNGEL A
Length:211
Mass (Da):23,149
Last modified:May 29, 2007 - v1
Checksum:iDE0240F782FB868B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000681 Genomic DNA Translation: ABP76470.1
RefSeqiWP_011788611.1, NC_009438.1

Genome annotation databases

EnsemblBacteriaiABP76470; ABP76470; Sputcn32_2751
KEGGispc:Sputcn32_2751

Similar proteinsi

Entry informationi

Entry nameiPIMT_SHEPC
AccessioniPrimary (citable) accession number: A4Y937
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 29, 2007
Last modified: April 25, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health