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Protein

NAD kinase

Gene

nadK

Organism
Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton acceptorUniRule annotation1
Binding sitei174NADUniRule annotation1
Binding sitei191NADUniRule annotation1
Binding sitei193NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi89 – 90NADUniRule annotation2
Nucleotide bindingi163 – 164NADUniRule annotation2
Nucleotide bindingi204 – 209NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Sputcn32_1273
OrganismiShewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Taxonomic identifieri319224 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000006699 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000795151 – 309NAD kinaseAdd BLAST309

Interactioni

Protein-protein interaction databases

STRINGi319224.Sputcn32_1273

Structurei

3D structure databases

ProteinModelPortaliA4Y4W8
SMRiA4Y4W8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227221
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

A4Y4W8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGINFDVSRP KARSSINMTT KFHTIGLIGK PHHLGTNQTL KRLHHWLTMQ
60 70 80 90 100
GYEVLAEERV STELGTNIEA VDLLEIGARC DLAIVVGGDG NMLGAARVLA
110 120 130 140 150
RFDLGVIGVN RGNLGFLTDL PPDAFEEALA RVLDGEFDTE HRFLLEAEVY
160 170 180 190 200
RHGMLKASNT AVNEAVLHPG KIAHMIEFEV YIDDQFMYSQ RADGMIVSTP
210 220 230 240 250
TGSTAYALSA GGAILTPNLQ ALILVPMFPH TLSCRPIVVD ACSTIKMVVS
260 270 280 290 300
PENGENLEVS CDGHVHLAVL PGDEIIIRRS SERLRLIHPK GHNYFHVLRT

KLGWGSKLF
Length:309
Mass (Da):33,938
Last modified:May 29, 2007 - v1
Checksum:iB6E4D669961A572D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000681 Genomic DNA Translation: ABP75001.1

Genome annotation databases

EnsemblBacteriaiABP75001; ABP75001; Sputcn32_1273
KEGGispc:Sputcn32_1273

Similar proteinsi

Entry informationi

Entry nameiNADK_SHEPC
AccessioniPrimary (citable) accession number: A4Y4W8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: April 25, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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