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A4Y4J1

- TYSY_SHEPC

UniProt

A4Y4J1 - TYSY_SHEPC

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Protein

Thymidylate synthase

Gene
thyA, Sputcn32_1146
Organism
Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei146 – 1461 By similarity

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

BioCyciSPUT319224:GHAP-1169-MONOMER.
UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthase (EC:2.1.1.45)
Short name:
TS
Short name:
TSase
Gene namesi
Name:thyA
Ordered Locus Names:Sputcn32_1146
OrganismiShewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Taxonomic identifieri319224 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000006699: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Thymidylate synthaseUniRule annotationPRO_1000000673Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi319224.Sputcn32_1146.

Structurei

3D structure databases

ProteinModelPortaliA4Y4J1.
SMRiA4Y4J1. Positions 1-264.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0207.
HOGENOMiHOG000257899.
KOiK00560.
OMAiDVHLYSN.
OrthoDBiEOG6K6V53.

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 2 hits.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4Y4J1-1 [UniParc]FASTAAdd to Basket

« Hide

MQQYLDLMKH ILAEGVDKSD RTGTGTRSVF GYQMRFDLSK GFPLVTTKKC    50
HMRSIIHELL WFLKGETNIA YLRENKVSIW DEWADDNGDL GPVYGAQWRS 100
WPTQSGDAID QISQVIAQIK AQPDSRRLIV SAWNVGELDK MALAPCHAFF 150
QFYVADGKLS CQLYQRSCDV FLGLPFNIAS YALLTMMVAQ QCDLALGDFV 200
WTGGDTHLYS NHMEQTVLQL SREPKPLPLM TILRKPESIF DYQFEDFELT 250
NYNPHPHIKA PVAV 264
Length:264
Mass (Da):30,145
Last modified:May 29, 2007 - v1
Checksum:i31AAE11FB35F0AFC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000681 Genomic DNA. Translation: ABP74874.1.
RefSeqiYP_001182673.1. NC_009438.1.

Genome annotation databases

EnsemblBacteriaiABP74874; ABP74874; Sputcn32_1146.
GeneIDi5081656.
KEGGispc:Sputcn32_1146.
PATRICi23550925. VBIShePut135485_1176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000681 Genomic DNA. Translation: ABP74874.1 .
RefSeqi YP_001182673.1. NC_009438.1.

3D structure databases

ProteinModelPortali A4Y4J1.
SMRi A4Y4J1. Positions 1-264.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 319224.Sputcn32_1146.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP74874 ; ABP74874 ; Sputcn32_1146 .
GeneIDi 5081656.
KEGGi spc:Sputcn32_1146.
PATRICi 23550925. VBIShePut135485_1176.

Phylogenomic databases

eggNOGi COG0207.
HOGENOMi HOG000257899.
KOi K00560.
OMAi DVHLYSN.
OrthoDBi EOG6K6V53.

Enzyme and pathway databases

UniPathwayi UPA00575 .
BioCyci SPUT319224:GHAP-1169-MONOMER.

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 2 hits.
PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CN-32 / ATCC BAA-453.

Entry informationi

Entry nameiTYSY_SHEPC
AccessioniPrimary (citable) accession number: A4Y4J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi