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A4Y4F7 (UPPP_SHEPC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Sputcn32_1112
OrganismShewanella putrefaciens (strain CN-32 / ATCC BAA-453) [Complete proteome] [HAMAP]
Taxonomic identifier319224 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000062814

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane39 – 5921Helical; Potential
Transmembrane87 – 10721Helical; Potential
Transmembrane111 – 13121Helical; Potential
Transmembrane149 – 16921Helical; Potential
Transmembrane183 – 20321Helical; Potential
Transmembrane218 – 23821Helical; Potential
Transmembrane246 – 26621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A4Y4F7 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 7E6139D4A385E859

FASTA26629,267
        10         20         30         40         50         60 
MDTFQVIILA LIQGLTEFLP ISSSAHLILP AELLGWEDQG LSFDVAVNTG SLLAVVIYFR 

        70         80         90        100        110        120 
HELWNMFTAW IASIFKGKQS DDSKLAWWII LATLPAVFFG FMAKDFIETH LRSAEVIAVT 

       130        140        150        160        170        180 
TIVFGLLLWW ADKMSHQDLT VYQTGWRKAL LIGFAQALAL IPGTSRSGAT MTAALMLGLS 

       190        200        210        220        230        240 
RDAAARFSFL MSVPVSLGAA ILVGKDLSES SLPIDYQALT LGTLVSFVAA YLCIHYFLKI 

       250        260 
ISRMGMTPFV IYRLILGAVL CGFIFL 

« Hide

References

[1]"Complete sequence of Shewanella putrefaciens CN-32."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Romine M.F., Fredrickson J., Tiedje J., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CN-32 / ATCC BAA-453.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000681 Genomic DNA. Translation: ABP74840.1.
RefSeqYP_001182639.1. NC_009438.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING319224.Sputcn32_1112.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP74840; ABP74840; Sputcn32_1112.
GeneID5081622.
KEGGspc:Sputcn32_1112.
PATRIC23550853. VBIShePut135485_1140.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAMENIGWK.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycSPUT319224:GHAP-1135-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_SHEPC
AccessionPrimary (citable) accession number: A4Y4F7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families