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Protein

S-ribosylhomocysteine lyase

Gene

luxS

Organism
Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).UniRule annotation

Catalytic activityi

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 1 Fe cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54IronUniRule annotation1
Metal bindingi58IronUniRule annotation1
Metal bindingi128IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAutoinducer synthesis, Quorum sensing
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
S-ribosylhomocysteine lyaseUniRule annotation (EC:4.4.1.21UniRule annotation)
Alternative name(s):
AI-2 synthesis proteinUniRule annotation
Autoinducer-2 production protein LuxSUniRule annotation
Gene namesi
Name:luxSUniRule annotation
Ordered Locus Names:Sputcn32_0938
OrganismiShewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Taxonomic identifieri319224 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000006699 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000048481 – 169S-ribosylhomocysteine lyaseAdd BLAST169

Proteomic databases

PRIDEiA4Y3Y4

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi319224.Sputcn32_0938

Structurei

3D structure databases

ProteinModelPortaliA4Y3Y4
SMRiA4Y3Y4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106762 Bacteria
COG1854 LUCA
HOGENOMiHOG000040371
KOiK07173
OMAiAIHTLEH
OrthoDBiPOG091H0623

Family and domain databases

Gene3Di3.30.1360.80, 1 hit
HAMAPiMF_00091 LuxS, 1 hit
InterProiView protein in InterPro
IPR037005 LuxS_sf
IPR011249 Metalloenz_LuxS/M16
IPR003815 S-ribosylhomocysteinase
PANTHERiPTHR35799 PTHR35799, 1 hit
PfamiView protein in Pfam
PF02664 LuxS, 1 hit
PIRSFiPIRSF006160 AI2, 1 hit
PRINTSiPR01487 LUXSPROTEIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013172 S-ribosylhomocysteinase, 1 hit
SUPFAMiSSF63411 SSF63411, 1 hit

Sequencei

Sequence statusi: Complete.

A4Y3Y4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLLDSFTVD HTRMNAPAVR VAKHMSTPKG DAITVFDLRF CTPNKEILSE
60 70 80 90 100
RGIHTLEHLF AGFMRDHLNS SNVEIIDISP MGCRTGFYMS LIGEPTEHQV
110 120 130 140 150
AVAWLAAMED VLKVVEQSEI PELNEYQCGT YEMHSLEQAQ EIARNIIAAG
160
VSVNRNDDLK LSDEILGKL
Length:169
Mass (Da):18,899
Last modified:May 29, 2007 - v1
Checksum:i187CBDD5C6C22F4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000681 Genomic DNA Translation: ABP74667.1
RefSeqiWP_011790501.1, NC_009438.1

Genome annotation databases

EnsemblBacteriaiABP74667; ABP74667; Sputcn32_0938
KEGGispc:Sputcn32_0938

Similar proteinsi

Entry informationi

Entry nameiLUXS_SHEPC
AccessioniPrimary (citable) accession number: A4Y3Y4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: April 25, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health