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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (Sputcn32_2235)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPUT319224:G1G8R-631-MONOMER
UniPathwayiUPA00074; UER00131

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotation (EC:6.3.2.6UniRule annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotation
Ordered Locus Names:Sputcn32_0608
OrganismiShewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Taxonomic identifieri319224 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000006699 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001178511 – 367Phosphoribosylaminoimidazole-succinocarboxamide synthaseAdd BLAST367

Interactioni

Protein-protein interaction databases

STRINGi319224.Sputcn32_0608

Structurei

3D structure databases

ProteinModelPortaliA4Y307
SMRiA4Y307
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8V Bacteria
COG0152 LUCA
HOGENOMiHOG000230361
KOiK01923
OMAiQKARPVM
OrthoDBiPOG091H01GT

Family and domain databases

HAMAPiMF_00137 SAICAR_synth, 1 hit
InterProiView protein in InterPro
IPR028923 SAICAR_synt/ADE2_N
IPR014106 SAICAR_synthase_Vibrio-typ
IPR018236 SAICAR_synthetase_CS
PfamiView protein in Pfam
PF01259 SAICAR_synt, 1 hit
TIGRFAMsiTIGR02735 purC_vibrio, 1 hit
PROSITEiView protein in PROSITE
PS01057 SAICAR_SYNTHETASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

A4Y307-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLADSVLAV NNDLPIRTDS PVHSGKVRSV YWLTDADSRR LIKTKGYNVP
60 70 80 90 100
EDTPLAIMVI SDRISAFDCI FHGEGGLKGI PGKGAALNAI SNHWFKLFAE
110 120 130 140 150
NGLADSHILD IPHPFVWIVQ KARPIKVEAI CRQYITGSMW RAYSKGERVF
160 170 180 190 200
CGITLPEGLE KDQKLPDLLI TPSTKGILTG IPGVPAQDDV NISRSDIEAN
210 220 230 240 250
YQAFGFEKLE DIDLYEKLLK DGFKVISKAL ADIDQVFVDT KFEFGYVTDK
260 270 280 290 300
DGNSKLIYMD EVGTPDSSRI WDGAAYRDGK ILENSKEGFR QFLLNHFPDP
310 320 330 340 350
DVLLNKDRMP EREALARDND LPLEAMMQVS RTYTGVAEKV TGAAIPLPAN
360
PKADIIKILR EEYDLIL
Length:367
Mass (Da):40,901
Last modified:May 29, 2007 - v1
Checksum:iC0229B18345CC47E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000681 Genomic DNA Translation: ABP74340.1
RefSeqiWP_011918610.1, NC_009438.1

Genome annotation databases

EnsemblBacteriaiABP74340; ABP74340; Sputcn32_0608
KEGGispc:Sputcn32_0608

Similar proteinsi

Entry informationi

Entry nameiPUR7_SHEPC
AccessioniPrimary (citable) accession number: A4Y307
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 29, 2007
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health