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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC:2.7.8.13)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene namesi
Name:mraY
Ordered Locus Names:Sputcn32_0484
OrganismiShewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Taxonomic identifieri319224 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000006699 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane ; Multi-pass membrane protein

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 46HelicalAdd BLAST21
Transmembranei74 – 94HelicalAdd BLAST21
Transmembranei97 – 117HelicalAdd BLAST21
Transmembranei134 – 154HelicalAdd BLAST21
Transmembranei168 – 188HelicalAdd BLAST21
Transmembranei199 – 219HelicalAdd BLAST21
Transmembranei236 – 256HelicalAdd BLAST21
Transmembranei263 – 283HelicalAdd BLAST21
Transmembranei288 – 308HelicalAdd BLAST21
Transmembranei338 – 358HelicalAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000030601 – 360Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST360

Interactioni

Protein-protein interaction databases

STRINGi319224.Sputcn32_0484.

Structurei

3D structure databases

SMRiA4Y2N3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A4Y2N3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVYLAEYLT RFYTGFNVFS YVTFRAILGL LTALIFSLWW GPKLIERLQL
60 70 80 90 100
LQIGQVVRND GPESHFSKRG TPTMGGLLIL AAIFISVLLW GDLGSRYVWV
110 120 130 140 150
MLFVLGSFGL IGFIDDYRKV VRKDTKGLIA RWKYILQSLA ALLIAFFLYA
160 170 180 190 200
TAANPGETQL VVPFFKDVMP QLGGVFIVLA YFTIVGSSNA VNLTDGLDGL
210 220 230 240 250
AIMPTVMVAA AFALIAYLSG HVQFANYLHI PHLPGSGELV IVCTAIVGAG
260 270 280 290 300
LGFLWFNTYP AQVFMGDVGS LSLGAALGAI AVLVRQEILL VIMGGVFVME
310 320 330 340 350
TVSVILQVGS YKLRGQRIFR MAPIHHHYEL KGWPEPRVIV RFWIISIFLV
360
LLGLATLKLR
Length:360
Mass (Da):39,753
Last modified:May 29, 2007 - v1
Checksum:i46505620442FCBD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000681 Genomic DNA. Translation: ABP74216.1.
RefSeqiWP_011787781.1. NC_009438.1.

Genome annotation databases

EnsemblBacteriaiABP74216; ABP74216; Sputcn32_0484.
KEGGispc:Sputcn32_0484.

Similar proteinsi

Entry informationi

Entry nameiMRAY_SHEPC
AccessioniPrimary (citable) accession number: A4Y2N3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: November 22, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families