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Protein

Catalase-peroxidase

Gene

katG

Organism
Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei94Transition state stabilizerUniRule annotation1
Active sitei98Proton acceptorUniRule annotation1
Metal bindingi266Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei3615. SputCP01_CN-32.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Sputcn32_0415
OrganismiShewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Taxonomic identifieri319224 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000006699 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003549221 – 728Catalase-peroxidaseAdd BLAST728

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki97 ↔ 225Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-251)UniRule annotation
Cross-linki225 ↔ 251Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-97)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi319224.Sputcn32_0415.

Structurei

3D structure databases

ProteinModelPortaliA4Y2G4.
SMRiA4Y2G4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiPEEDIYW.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiView protein in InterPro
IPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
PANTHERiPTHR30555. PTHR30555. 1 hit.
PfamiView protein in Pfam
PF00141. peroxidase. 2 hits.
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiView protein in PROSITE
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.

Sequencei

Sequence statusi: Complete.

A4Y2G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKTHSSQGK CPVMHGGNTS VTTNNMDWWP KALNLDILHQ HDKKTDPMDP
60 70 80 90 100
TFNYSEAFKT LDLAAVKQDL YALMTDSQDW WPADWGHYGG LMIRMAWHSA
110 120 130 140 150
GTYRIADGRG GAGTGNQRFA PLNSWPDNAN LDKARRLLWP IKKKYGNKLS
160 170 180 190 200
WADLIILAGN VAYESMGLKT YGFAGGRADI WHPEKDIYWG SEKQWLAPSD
210 220 230 240 250
NPNSRYSGER DLENPLAAVM MGLIYVNPEG VDGNPDPLRT AQDIRITFAR
260 270 280 290 300
MAMDDEETVA LTAGGHTVGK CHGNGKAQNL GPEPEAEDVE AQGLGWLNKH
310 320 330 340 350
GRGVGRNTVT SGIEGAWTTH PTQWDNGYFS LLLGYDWELK KSPAGAWQWE
360 370 380 390 400
PINIKEEDKP VDVEDPTIRH NPIMTDADMA MKMDPEYRKI SEKFYKDPAY
410 420 430 440 450
FSEVFARAWF KLTHRDLGPK SRYLGPEVPA EDLIWQDPIP QVDYRLSDDD
460 470 480 490 500
ITALKAKILA SGLSIAELVT TAWDSARTFR GSDYRGGANG ARIRLAPQKD
510 520 530 540 550
WEGNEPVRLQ KVLKVLTDIQ TGLSQKVSIA DLIVLGGTAA VEKAAQDAGV
560 570 580 590 600
NIRVPFASGR GDASQEMTDI ESFAVLEPLH DAYRNWQKKD YVVQPEELML
610 620 630 640 650
DRTQLMGLTA HEMTVLIGGM RVLGANYAGS AHGVFTDRVG VLSNDFFVNL
660 670 680 690 700
TDMSYNWKPA GNNLYQIIER KTGTVKWTAT RVDLVFGSNS VLRSYAEIYA
710 720
QDDAKEKFVH DFVNAWTKVM NADRFDLA
Length:728
Mass (Da):81,303
Last modified:May 29, 2007 - v1
Checksum:iD34F34094D910084
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000681 Genomic DNA. Translation: ABP74147.1.
RefSeqiWP_011787666.1. NC_009438.1.

Genome annotation databases

EnsemblBacteriaiABP74147; ABP74147; Sputcn32_0415.
KEGGispc:Sputcn32_0415.

Similar proteinsi

Entry informationi

Entry nameiKATG_SHEPC
AccessioniPrimary (citable) accession number: A4Y2G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 29, 2007
Last modified: November 22, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families