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A4Y119

- GCH4_PSEMY

UniProt

A4Y119 - GCH4_PSEMY

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pseudomonas mendocina (strain ymp)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei149 – 1491May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPMEN399739:GHR6-4618-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Pmen_4538
OrganismiPseudomonas mendocina (strain ymp)
Taxonomic identifieri399739 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000229: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296GTP cyclohydrolase FolE2PRO_0000316532Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399739.Pmen_4538.

Structurei

3D structure databases

ProteinModelPortaliA4Y119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiAGRTTIQ.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4Y119-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNEQLLPDIA AQATHHDLPL HWVGMAGIAL PIQLAGQALN ASVDIGVSLD
60 70 80 90 100
DAGARGIHMS RLYLALQGLA GKPLTLAALQ HLLDDCLSSH HELSDSASLT
110 120 130 140 150
VRGALPLQRP ALVSQLSGWK HYPFEIHARQ DGRGLHMELQ VELDYSSTCP
160 170 180 190 200
CSAALARQLI QQRFAESFAQ QPLNYLDVLD WLGSTQGIVA TPHSQRSTAT
210 220 230 240 250
LQLRLAADCI DLPLLALLEA AERALGTPVQ TAVKRADEQA FALANGQNLM
260 270 280 290
FCEDAARRLH RALRQLPQAS AFRVRVVHAE SLHAHDAVAE SRWNWS
Length:296
Mass (Da):32,255
Last modified:May 29, 2007 - v1
Checksum:i4A071CD945AE2F72
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000680 Genomic DNA. Translation: ABP87285.1.
RefSeqiWP_012020267.1. NC_009439.1.
YP_001190017.1. NC_009439.1.

Genome annotation databases

EnsemblBacteriaiABP87285; ABP87285; Pmen_4538.
GeneIDi5106996.
KEGGipmy:Pmen_4538.
PATRICi19915770. VBIPseMen131592_4602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000680 Genomic DNA. Translation: ABP87285.1 .
RefSeqi WP_012020267.1. NC_009439.1.
YP_001190017.1. NC_009439.1.

3D structure databases

ProteinModelPortali A4Y119.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399739.Pmen_4538.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP87285 ; ABP87285 ; Pmen_4538 .
GeneIDi 5106996.
KEGGi pmy:Pmen_4538.
PATRICi 19915770. VBIPseMen131592_4602.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi AGRTTIQ.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci PMEN399739:GHR6-4618-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ymp.

Entry informationi

Entry nameiGCH4_PSEMY
AccessioniPrimary (citable) accession number: A4Y119
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3