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A4XZZ7

- TRMB_PSEMY

UniProt

A4XZZ7 - TRMB_PSEMY

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, Pmen_4166
Organism
Pseudomonas mendocina (strain ymp)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei68 – 681S-adenosyl-L-methionine By similarity
Binding sitei93 – 931S-adenosyl-L-methionine By similarity
Binding sitei120 – 1201S-adenosyl-L-methionine By similarity
Active sitei143 – 1431 By similarity
Binding sitei143 – 1431S-adenosyl-L-methionine By similarity
Binding sitei147 – 1471Substrate By similarity
Binding sitei179 – 1791Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciPMEN399739:GHR6-4239-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:Pmen_4166
OrganismiPseudomonas mendocina (strain ymp)
Taxonomic identifieri399739 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000229: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_1000064404Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399739.Pmen_4166.

Structurei

3D structure databases

ProteinModelPortaliA4XZZ7.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni216 – 2194Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiHSTLEMA.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4XZZ7-1 [UniParc]FASTAAdd to Basket

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MTDTQQPELT EDGRQRRTIK SFVMRAGRMT EGQQRGLDKG WPLFGLELED    50
GLRDFDQVFG RSAPRTFEIG FGMGHSTLEM AAAAPEQDFI GVEVHKPGVG 100
ALLNGVMAHN LSNVRVYSCD ALEVLQGCVA DASLDRVLLF FPDPWHKSRH 150
HKRRIVQPAF AELVRRKLKI GGVLHMATDW ENYAEHMLEV MNAAPGYRNL 200
AADGTYVPRP EERPVTKFER RGERLGHGVW DLKFQRQE 238
Length:238
Mass (Da):26,996
Last modified:May 29, 2007 - v1
Checksum:i476AD5BEF9876603
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000680 Genomic DNA. Translation: ABP86913.1.
RefSeqiYP_001189645.1. NC_009439.1.

Genome annotation databases

EnsemblBacteriaiABP86913; ABP86913; Pmen_4166.
GeneIDi5105685.
KEGGipmy:Pmen_4166.
PATRICi19914984. VBIPseMen131592_4217.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000680 Genomic DNA. Translation: ABP86913.1 .
RefSeqi YP_001189645.1. NC_009439.1.

3D structure databases

ProteinModelPortali A4XZZ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399739.Pmen_4166.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP86913 ; ABP86913 ; Pmen_4166 .
GeneIDi 5105685.
KEGGi pmy:Pmen_4166.
PATRICi 19914984. VBIPseMen131592_4217.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi HSTLEMA.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci PMEN399739:GHR6-4239-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ymp.

Entry informationi

Entry nameiTRMB_PSEMY
AccessioniPrimary (citable) accession number: A4XZZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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