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Protein

Catalase-peroxidase

Gene

katG

Organism
Pseudomonas mendocina (strain ymp)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei88 – 881Transition state stabilizerUniRule annotation
Active sitei92 – 921Proton acceptorUniRule annotation
Metal bindingi257 – 2571Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciPMEN399739:GHR6-3944-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Pmen_3881
OrganismiPseudomonas mendocina (strain ymp)
Taxonomic identifieri399739 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000229 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 716716Catalase-peroxidasePRO_0000354865Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki91 ↔ 216Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-242)UniRule annotation
Cross-linki216 ↔ 242Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-91)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA4XZ62.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi399739.Pmen_3881.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4XZ62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNQGKCPFN HVAGGGTTNK DWWPNQLRVD LLNQHSDRSN PLGEKFNYAE
60 70 80 90 100
AFKKLDYKAL KADLVRLMTD SQDWWPADFG HYGPQFIRMA WHSAGTYRTT
110 120 130 140 150
DGRGGGGRGQ QRFAPLNSWP DNVNIDKSRR LLWPIKQKYG QSISWADLYI
160 170 180 190 200
LAGNVALESM GFRTFGFGAG REDVWEPDQD VNWGAEVAWL GVDPKRVNDE
210 220 230 240 250
RELTAPFGAT HMGLIYVNPE GPNASGDYLA AAKDIRATFY RMAMNDEEIV
260 270 280 290 300
ALIAGGHTFG KAHGAAPESH KGPEPEGAPI EAQGLGWTSN FGSGFGKDTV
310 320 330 340 350
SSGLEVTWTK TPALWSNNFF ENLFKFEWEL TKSPAGAKQW VAKDAPEIIP
360 370 380 390 400
DAHVPGKFHK PTMLTTDLTL RFDPEFGKIS KRFYEDPQAF ADAFARAWYK
410 420 430 440 450
LTHRDMGPKA RYLGPEVPKE DLIWQDPLPA AIHNPSAADI ADLKARIAAS
460 470 480 490 500
GLSVGDLVSV AWASASTFRG GDKRGGANGA RLALAPQKDW EANQRAIKVL
510 520 530 540 550
PKLVEIQQAS GKASLADVIV LAGNVGVEQA AKAAGVAVDV PFAAGRVDAR
560 570 580 590 600
QDQTDVESFD VLESAADGFR NYSKGNLGVP TETMLVDKAQ LLTLTAPELT
610 620 630 640 650
ALVGGLRVLG ANYDGSQHGV FTDKVGVLSN DFFVNLLDMN TVWKAVDDSN
660 670 680 690 700
EVFEGRGRKD GQVKYTATRN DLVFGSNSIL RAYAEVYASS DGKEKLVKDF
710
VAAWTKVMNL DRFDLA
Length:716
Mass (Da):78,341
Last modified:May 29, 2007 - v1
Checksum:iBCDF2396F57541CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000680 Genomic DNA. Translation: ABP86628.1.
RefSeqiWP_012019778.1. NC_009439.1.

Genome annotation databases

EnsemblBacteriaiABP86628; ABP86628; Pmen_3881.
GeneIDi5106415.
KEGGipmy:Pmen_3881.
PATRICi19914398. VBIPseMen131592_3934.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000680 Genomic DNA. Translation: ABP86628.1.
RefSeqiWP_012019778.1. NC_009439.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399739.Pmen_3881.

Proteomic databases

PRIDEiA4XZ62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP86628; ABP86628; Pmen_3881.
GeneIDi5106415.
KEGGipmy:Pmen_3881.
PATRICi19914398. VBIPseMen131592_3934.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Enzyme and pathway databases

BioCyciPMEN399739:GHR6-3944-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ymp.

Entry informationi

Entry nameiKATG_PSEMY
AccessioniPrimary (citable) accession number: A4XZ62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 29, 2007
Last modified: November 11, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.