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A4XYW8

- SYL_PSEMY

UniProt

A4XYW8 - SYL_PSEMY

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pseudomonas mendocina (strain ymp)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei632 – 6321ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMEN399739:GHR6-3849-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Pmen_3786
    OrganismiPseudomonas mendocina (strain ymp)
    Taxonomic identifieri399739 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000229: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 870870Leucine--tRNA ligasePRO_0000334794Add
    BLAST

    Proteomic databases

    PRIDEiA4XYW8.

    Interactioni

    Protein-protein interaction databases

    STRINGi399739.Pmen_3786.

    Structurei

    3D structure databases

    ProteinModelPortaliA4XYW8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi629 – 6335"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 2 hits.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4XYW8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHEQYSPREI EAAAQSHWDA QKSFVVSEQP GKDTFYCLSM FPYPSGKLHM    50
    GHVRNYTIGD VIARYQRMQG KNVLQPMGWD AFGMPAENAA MKNQVAPAKW 100
    TYENIAYMKS QLKSLGLAID WTREVTTCKP DYYRWEQWLF TRLFEKGVIY 150
    RKNGTVNWDP VDQTVLANEQ VIDGRGWRSG ALIEKREIPM YYFKITAYAD 200
    ELLSSLDELD GWPEQVKTMQ RNWIGKSFGA DIVFDYDVAS IGIDGQLKVY 250
    STRPDTLMGA TYVAVAAEHP LAQRAAESNP AIAAFIAECK AGSVAEADMA 300
    TMEKKGLATG QFVIHPLTGD KLPVFVANYV LWGYGEGAVM AVPAHDERDF 350
    EFANKYDLPI KQVYTGEGKD YDASTWQDWY GDKAGLTTIN SGKYDGLDFS 400
    AAFDAIVGDL EASAHGARKT QFRLRDWGIS RQRYWGCPIP IIHCDSCGDV 450
    PVPEDQLPVV LPEDVVPDGA GSPLAKMPEF YECTCPKCGA PAKRETDTMD 500
    TFVESSWYFA RYASPNYEGG MVDPQAANHW LPVDQYIGGI EHAILHLLYA 550
    RFFHKLMRDE GLVSSNEPFK NLLTQGMVVA ETYYRTLENG GKDWFNPADV 600
    EVERDAKAKV IGAKLKSDGL PVEIGGTEKM SKSKNNGVDP QDMIDAYGAD 650
    TCRLFMMFAS PPDMSCEWSD AGVEGANRFL RRVWRLAHGH VSAGLPGKLD 700
    VASLSDEQKA VRRAIHLAIK QASNDIGQHH KFNTAIAQVM TLMNVLEKAA 750
    TATEQDRALV QEGLEIVTLL LAPITPHISH ELWQRLGHAD AVIDAQWPQV 800
    DESALVQDSL TLVVQVNGKL RGQIEVPASA SREDVEAAAR ANENVLRFTE 850
    GLSIRKVIVV PGKLVNIVAN 870
    Length:870
    Mass (Da):96,711
    Last modified:May 20, 2008 - v2
    Checksum:i068FCFFC99162D69
    GO

    Sequence cautioni

    The sequence ABP86534.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000680 Genomic DNA. Translation: ABP86534.1. Different initiation.
    RefSeqiYP_001189266.1. NC_009439.1.

    Genome annotation databases

    EnsemblBacteriaiABP86534; ABP86534; Pmen_3786.
    GeneIDi5106017.
    KEGGipmy:Pmen_3786.
    PATRICi19914208. VBIPseMen131592_3839.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000680 Genomic DNA. Translation: ABP86534.1 . Different initiation.
    RefSeqi YP_001189266.1. NC_009439.1.

    3D structure databases

    ProteinModelPortali A4XYW8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399739.Pmen_3786.

    Proteomic databases

    PRIDEi A4XYW8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP86534 ; ABP86534 ; Pmen_3786 .
    GeneIDi 5106017.
    KEGGi pmy:Pmen_3786.
    PATRICi 19914208. VBIPseMen131592_3839.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PMEN399739:GHR6-3849-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 2 hits.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ymp.

    Entry informationi

    Entry nameiSYL_PSEMY
    AccessioniPrimary (citable) accession number: A4XYW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 53 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3