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A4XYC7 (A4XYC7_PSEMY) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A synthetase 2 HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123
Alternative name(s):
Acetate--CoA ligase 2 HAMAP MF_01123
Acyl-activating enzyme 2 HAMAP MF_01123
Gene names
Name:acsA2 HAMAP MF_01123
Ordered Locus Names:Pmen_3595
OrganismPseudomonas mendocina (strain ymp) [Complete proteome] [HAMAP] EMBL ABP86343.1
Taxonomic identifier399739 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length645 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site5141 By similarity HAMAP MF_01123

Amino acid modifications

Modified residue6061N6-acetyllysine By similarity HAMAP MF_01123

Sequences

Sequence LengthMass (Da)Tools
A4XYC7 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 928B353F423E4824

FASTA64571,789
        10         20         30         40         50         60 
MFEITRHPVA DAVRQRAHLD NDAYLRLYQQ SVEQPDTFWA EQAKAFLTWF KPWDQVHSSD 

        70         80         90        100        110        120 
LKQGRAEWFK GGQLNVAYNC IDRHLQQRGE QVAIIWEGDN PAESAHITYN KLHHNVSRLA 

       130        140        150        160        170        180 
NVLKRRGVKK GDRVCIYMPM VPEAAYAMLA CARIGAVHSV VFGGFSPDAL RDRILDADCR 

       190        200        210        220        230        240 
TVITADEGVR GGKYIPLKNN VDKALQSCPN VSTVVVVERT QGDVAWVEGR DLWYHQALKE 

       250        260        270        280        290        300 
VDADCPAEPM DAEDPLFILY TSGSTGKPKG VLHTTGGYLL GAAMTHKYVF DYHEGDVYWC 

       310        320        330        340        350        360 
TADVGWVTGH SYIVYGPLAN AATTLMFEGV PNYPDASRFW QVIDKHQVNT FYTAPTALRA 

       370        380        390        400        410        420 
LMREGEAPVK ATSRSSLRLL GTVGEPINPE AWEWYFHVVG DMRCPIVDTW WQTETGSILI 

       430        440        450        460        470        480 
TPLPGATDLK PGSATRPFFG VQPVLLDEQG KEIEGPGAGV LAIKASWPSQ IRSVYGDHQR 

       490        500        510        520        530        540 
MVDTYFKPYP GYYFTGDGAR RDEDGYYWIT GRVDDVINVS GHRIGTAEVE SALVLHDAVA 

       550        560        570        580        590        600 
EAAVVGYPHD VKGQGIYAYV TLMNGQEPSD ELKKDLLALV GKEIGSFAKP ELIQWAPGLP 

       610        620        630        640 
KTRSGKIMRR ILRKIACNEL ENMGDTSTLA DPSVVDSLID QRLNR

« Hide

References

[1]"Complete sequence of Pseudomonas mendocina ymp."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Detter J.C., Bruce D., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Mikhailova N., Hersman L., Dubois J., Maurice P., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ymp.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000680 Genomic DNA. Translation: ABP86343.1.
RefSeqYP_001189075.1. NC_009439.1.

3D structure databases

ProteinModelPortalA4XYC7.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4XYC7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5106142.
GenomeReviewsGene locus Pmen_3595 in contig CP000680_GR.
KEGGpmy:Pmen_3595.
PATRIC19913814. VBIPseMen131592_3644.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0365.
HOGENOMHBG547964.
OMAHQRMVDT.
PhylomeDBA4XYC7.
ProtClustDBPRK00174.

Enzyme and pathway databases

BioCycPMEN399739:PMEN_3595-MONOMER.

Family and domain databases

HAMAPMF_01123. Ac_CoA_synth.
[Tree]
InterProIPR011904. Ac_CoA_lig.
IPR024597. Acyl-CoA_synth_DUF3448.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
KOK01895.
PANTHERPTHR24095:SF42. PTHR24095:SF42. 1 hit.
PfamPF00501. AMP-binding. 1 hit.
PF11930. DUF3448. 1 hit.
[Graphical view]
TIGRFAMsTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4XYC7_PSEMY
AccessionPrimary (citable) accession number: A4XYC7
Entry history
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info