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A4XWS8

- LPXB_PSEMY

UniProt

A4XWS8 - LPXB_PSEMY

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Pseudomonas mendocina (strain ymp)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciPMEN399739:GHR6-3099-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:Pmen_3040
    OrganismiPseudomonas mendocina (strain ymp)
    Taxonomic identifieri399739 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000229: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 377377Lipid-A-disaccharide synthasePRO_1000060772Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi399739.Pmen_3040.

    Structurei

    3D structure databases

    ProteinModelPortaliA4XWS8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4XWS8-1 [UniParc]FASTAAdd to Basket

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    MSRPIRVALV AGEASGDILG SGLMQAIKAR HPDAEFIGVG GARMEAEGLK    50
    SYFPMERLAV MGLVEVLGRL FELLGRRRQL ARDLIAAKPD VFIGIDAPDF 100
    NLGLELKLRR AGIKTVHYVS PSVWAWRQKR VLKIREACDL MLTLFPFEAQ 150
    FYDAHQVPVR FVGHPLADAI PQQADRAAAR EALDLPQDGP VVALMPGSRG 200
    GEVARLGDLF LDAAIRLRAL RPGVRFLLPC ATPERRAQLE QMLASRDLPL 250
    TLLDGRSHEA LAACDAVLIA SGTATLEALL YKRPMVVAYR VAPLTYRILK 300
    RLVKSPYISL PNLLAERLLV PELIQEAATA EALAQAVAPL IDGGQVQTEG 350
    FDVIHRALRR DASVSAADAV LKLAGRD 377
    Length:377
    Mass (Da):41,085
    Last modified:May 29, 2007 - v1
    Checksum:i0967470818F70C1F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000680 Genomic DNA. Translation: ABP85794.1.
    RefSeqiYP_001188526.1. NC_009439.1.

    Genome annotation databases

    EnsemblBacteriaiABP85794; ABP85794; Pmen_3040.
    GeneIDi5107520.
    KEGGipmy:Pmen_3040.
    PATRICi19912692. VBIPseMen131592_3086.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000680 Genomic DNA. Translation: ABP85794.1 .
    RefSeqi YP_001188526.1. NC_009439.1.

    3D structure databases

    ProteinModelPortali A4XWS8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399739.Pmen_3040.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP85794 ; ABP85794 ; Pmen_3040 .
    GeneIDi 5107520.
    KEGGi pmy:Pmen_3040.
    PATRICi 19912692. VBIPseMen131592_3086.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci PMEN399739:GHR6-3099-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ymp.

    Entry informationi

    Entry nameiLPXB_PSEMY
    AccessioniPrimary (citable) accession number: A4XWS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3