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A4XWS8

- LPXB_PSEMY

UniProt

A4XWS8 - LPXB_PSEMY

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, Pmen_3040
Organism
Pseudomonas mendocina (strain ymp)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciPMEN399739:GHR6-3099-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Pmen_3040
OrganismiPseudomonas mendocina (strain ymp)
Taxonomic identifieri399739 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000229: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Lipid-A-disaccharide synthaseUniRule annotationPRO_1000060772Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399739.Pmen_3040.

Structurei

3D structure databases

ProteinModelPortaliA4XWS8.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

A4XWS8-1 [UniParc]FASTAAdd to Basket

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MSRPIRVALV AGEASGDILG SGLMQAIKAR HPDAEFIGVG GARMEAEGLK    50
SYFPMERLAV MGLVEVLGRL FELLGRRRQL ARDLIAAKPD VFIGIDAPDF 100
NLGLELKLRR AGIKTVHYVS PSVWAWRQKR VLKIREACDL MLTLFPFEAQ 150
FYDAHQVPVR FVGHPLADAI PQQADRAAAR EALDLPQDGP VVALMPGSRG 200
GEVARLGDLF LDAAIRLRAL RPGVRFLLPC ATPERRAQLE QMLASRDLPL 250
TLLDGRSHEA LAACDAVLIA SGTATLEALL YKRPMVVAYR VAPLTYRILK 300
RLVKSPYISL PNLLAERLLV PELIQEAATA EALAQAVAPL IDGGQVQTEG 350
FDVIHRALRR DASVSAADAV LKLAGRD 377
Length:377
Mass (Da):41,085
Last modified:May 29, 2007 - v1
Checksum:i0967470818F70C1F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000680 Genomic DNA. Translation: ABP85794.1.
RefSeqiYP_001188526.1. NC_009439.1.

Genome annotation databases

EnsemblBacteriaiABP85794; ABP85794; Pmen_3040.
GeneIDi5107520.
KEGGipmy:Pmen_3040.
PATRICi19912692. VBIPseMen131592_3086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000680 Genomic DNA. Translation: ABP85794.1 .
RefSeqi YP_001188526.1. NC_009439.1.

3D structure databases

ProteinModelPortali A4XWS8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399739.Pmen_3040.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP85794 ; ABP85794 ; Pmen_3040 .
GeneIDi 5107520.
KEGGi pmy:Pmen_3040.
PATRICi 19912692. VBIPseMen131592_3086.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci PMEN399739:GHR6-3099-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ymp.

Entry informationi

Entry nameiLPXB_PSEMY
AccessioniPrimary (citable) accession number: A4XWS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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