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A4XWS8

- LPXB_PSEMY

UniProt

A4XWS8 - LPXB_PSEMY

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Pseudomonas mendocina (strain ymp)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciPMEN399739:GHR6-3099-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:Pmen_3040
OrganismiPseudomonas mendocina (strain ymp)
Taxonomic identifieri399739 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000229: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Lipid-A-disaccharide synthasePRO_1000060772Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399739.Pmen_3040.

Structurei

3D structure databases

ProteinModelPortaliA4XWS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

A4XWS8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRPIRVALV AGEASGDILG SGLMQAIKAR HPDAEFIGVG GARMEAEGLK
60 70 80 90 100
SYFPMERLAV MGLVEVLGRL FELLGRRRQL ARDLIAAKPD VFIGIDAPDF
110 120 130 140 150
NLGLELKLRR AGIKTVHYVS PSVWAWRQKR VLKIREACDL MLTLFPFEAQ
160 170 180 190 200
FYDAHQVPVR FVGHPLADAI PQQADRAAAR EALDLPQDGP VVALMPGSRG
210 220 230 240 250
GEVARLGDLF LDAAIRLRAL RPGVRFLLPC ATPERRAQLE QMLASRDLPL
260 270 280 290 300
TLLDGRSHEA LAACDAVLIA SGTATLEALL YKRPMVVAYR VAPLTYRILK
310 320 330 340 350
RLVKSPYISL PNLLAERLLV PELIQEAATA EALAQAVAPL IDGGQVQTEG
360 370
FDVIHRALRR DASVSAADAV LKLAGRD
Length:377
Mass (Da):41,085
Last modified:May 29, 2007 - v1
Checksum:i0967470818F70C1F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000680 Genomic DNA. Translation: ABP85794.1.
RefSeqiWP_003244219.1. NC_009439.1.
YP_001188526.1. NC_009439.1.

Genome annotation databases

EnsemblBacteriaiABP85794; ABP85794; Pmen_3040.
GeneIDi5107520.
KEGGipmy:Pmen_3040.
PATRICi19912692. VBIPseMen131592_3086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000680 Genomic DNA. Translation: ABP85794.1 .
RefSeqi WP_003244219.1. NC_009439.1.
YP_001188526.1. NC_009439.1.

3D structure databases

ProteinModelPortali A4XWS8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399739.Pmen_3040.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP85794 ; ABP85794 ; Pmen_3040 .
GeneIDi 5107520.
KEGGi pmy:Pmen_3040.
PATRICi 19912692. VBIPseMen131592_3086.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci PMEN399739:GHR6-3099-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ymp.

Entry informationi

Entry nameiLPXB_PSEMY
AccessioniPrimary (citable) accession number: A4XWS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3