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Protein

Ribonuclease HII

Gene

rnhB

Organism
Pseudomonas mendocina (strain ymp)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mn2+UniRule annotation, Mg2+UniRule annotationNote: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi18 – 181Divalent metal cationUniRule annotation
Metal bindingi19 – 191Divalent metal cationUniRule annotation
Metal bindingi110 – 1101Divalent metal cationUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciPMEN399739:GHR6-3098-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HIIUniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase HIIUniRule annotation
Gene namesi
Name:rnhBUniRule annotation
Ordered Locus Names:Pmen_3039
OrganismiPseudomonas mendocina (strain ymp)
Taxonomic identifieri399739 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000229 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Ribonuclease HIIPRO_1000031182Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399739.Pmen_3039.

Structurei

3D structure databases

ProteinModelPortaliA4XWS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase HII family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UH2. Bacteria.
COG0164. LUCA.
HOGENOMiHOG000100288.
KOiK03470.
OMAiGFASHKG.
OrthoDBiEOG6BKJC8.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00052_B. RNase_HII_B.
InterProiIPR022898. RNase_HII.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10954. PTHR10954. 1 hit.
PfamiPF01351. RNase_HII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

A4XWS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLGLDFSLV EELVAGVDEV GRGPLCGAVV TAAVILDPLR PIIGLNDSKK
60 70 80 90 100
LTEARREVLF DEIREKALAW CIARAEVEEI DRLNILHATM LAMQRAVEGL
110 120 130 140 150
SVTPKLALID GNRCPRLTVP SAPVVKGDSR VPAIAAASIL AKVSRDREML
160 170 180 190 200
EMDRLYPGYG IAGHKGYPTP VHLEALQRLG PTPIHRRSFA PVRALLEPVA

VDCIAATV
Length:208
Mass (Da):22,494
Last modified:May 29, 2007 - v1
Checksum:iC0B58C28D2EB7129
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000680 Genomic DNA. Translation: ABP85793.1.
RefSeqiWP_012019181.1. NC_009439.1.

Genome annotation databases

EnsemblBacteriaiABP85793; ABP85793; Pmen_3039.
GeneIDi5107519.
KEGGipmy:Pmen_3039.
PATRICi19912690. VBIPseMen131592_3085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000680 Genomic DNA. Translation: ABP85793.1.
RefSeqiWP_012019181.1. NC_009439.1.

3D structure databases

ProteinModelPortaliA4XWS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399739.Pmen_3039.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP85793; ABP85793; Pmen_3039.
GeneIDi5107519.
KEGGipmy:Pmen_3039.
PATRICi19912690. VBIPseMen131592_3085.

Phylogenomic databases

eggNOGiENOG4108UH2. Bacteria.
COG0164. LUCA.
HOGENOMiHOG000100288.
KOiK03470.
OMAiGFASHKG.
OrthoDBiEOG6BKJC8.

Enzyme and pathway databases

BioCyciPMEN399739:GHR6-3098-MONOMER.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00052_B. RNase_HII_B.
InterProiIPR022898. RNase_HII.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10954. PTHR10954. 1 hit.
PfamiPF01351. RNase_HII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ymp.

Entry informationi

Entry nameiRNH2_PSEMY
AccessioniPrimary (citable) accession number: A4XWS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: December 9, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.