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A4XWI3

- NADK_PSEMY

UniProt

A4XWI3 - NADK_PSEMY

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Protein

NAD kinase

Gene

nadK

Organism
Pseudomonas mendocina (strain ymp)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei72 – 721Proton acceptorUniRule annotation
Binding sitei157 – 1571NADUniRule annotation
Binding sitei174 – 1741NADUniRule annotation
Binding sitei176 – 1761NADUniRule annotation
Binding sitei247 – 2471NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi72 – 732NADUniRule annotation
Nucleotide bindingi146 – 1472NADUniRule annotation
Nucleotide bindingi187 – 1926NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMEN399739:GHR6-3000-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Pmen_2944
OrganismiPseudomonas mendocina (strain ymp)
Taxonomic identifieri399739 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000229: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295NAD kinasePRO_1000005431Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399739.Pmen_2944.

Structurei

3D structure databases

ProteinModelPortaliA4XWI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227221.
KOiK00858.
OMAiTHEMLYH.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A4XWI3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEQFRNVGII GRLGSTRVLE TVRRLKRFLI DRHLHVILED TIADVLPGHG
60 70 80 90 100
LQTSSRKMLG EVCDLVIVVG GDGSMLGAAR ALARHKVPVL GINRGSLGFL
110 120 130 140 150
TDIRPDELEL KVAQVLEGQY LTENRFLLEA EVRRQGEAIG QGDALNDVVL
160 170 180 190 200
HPGKSTRMIE FELYIDGQFV CSQKADGLIV ATPTGSTAYA LSAGGPIMHP
210 220 230 240 250
KLDAIVVVPM YPHTLSSRPI VVDGNSELKV VVSPDMTIYP QVSCDGQNHF
260 270 280 290
TCAPGDTLHV AKKAQKLRLI HPLDHNYYEV CRTKLGWGSR LGGHD
Length:295
Mass (Da):32,267
Last modified:May 29, 2007 - v1
Checksum:i2CCF0B8C7EA4BAB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000680 Genomic DNA. Translation: ABP85699.1.
RefSeqiWP_003244398.1. NC_009439.1.
YP_001188431.1. NC_009439.1.

Genome annotation databases

EnsemblBacteriaiABP85699; ABP85699; Pmen_2944.
GeneIDi5107662.
KEGGipmy:Pmen_2944.
PATRICi19912488. VBIPseMen131592_2987.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000680 Genomic DNA. Translation: ABP85699.1 .
RefSeqi WP_003244398.1. NC_009439.1.
YP_001188431.1. NC_009439.1.

3D structure databases

ProteinModelPortali A4XWI3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399739.Pmen_2944.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP85699 ; ABP85699 ; Pmen_2944 .
GeneIDi 5107662.
KEGGi pmy:Pmen_2944.
PATRICi 19912488. VBIPseMen131592_2987.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227221.
KOi K00858.
OMAi THEMLYH.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci PMEN399739:GHR6-3000-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ymp.

Entry informationi

Entry nameiNADK_PSEMY
AccessioniPrimary (citable) accession number: A4XWI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: November 26, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3