ID   ASTD_PSEMY              Reviewed;         487 AA.
AC   A4XWE7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   16-JUN-2009, entry version 17.
DE   RecName: Full=N-succinylglutamate 5-semialdehyde dehydrogenase;
DE            EC=1.2.1.71;
DE   AltName: Full=Succinylglutamic semialdehyde dehydrogenase;
DE            Short=SGSD;
GN   Name=astD; OrderedLocusNames=Pmen_2908;
OS   Pseudomonas mendocina (strain ymp).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=399739;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Detter J.C.,
RA   Bruce D., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Hersman L., Dubois J., Maurice P.,
RA   Richardson P.;
RT   "Complete sequence of Pseudomonas mendocina ymp.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the NAD-dependent reduction of
CC       succinylglutamate semialdehyde into succinylglutamate (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: N-succinyl-L-glutamate 5-semialdehyde + NAD(+)
CC       + H(2)O = N-succinyl-L-glutamate + NADH.
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via AST
CC       pathway; L-glutamate and succinate from L-arginine: step 4/5.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD
CC       subfamily.
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DR   EMBL; CP000680; ABP85663.1; -; Genomic_DNA.
DR   RefSeq; YP_001188395.1; -.
DR   GeneID; 5107626; -.
DR   GenomeReviews; CP000680_GR; Pmen_2908.
DR   KEGG; pmy:Pmen_2908; -.
DR   OMA; A4XWE7; FAPLLQV.
DR   GO; GO:0043824; F:succinylglutamate-semialdehyde dehydrogenas...; IEA:EC.
DR   GO; GO:0019544; P:arginine catabolic process to glutamate; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01174; -; 1.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR017649; SuccinylGlu_semiald_DH_AstD.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR03240; arg_catab_astD; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    487       N-succinylglutamate 5-semialdehyde
FT                                dehydrogenase.
FT                                /FTId=PRO_1000065761.
FT   NP_BIND     221    226       NAD (By similarity).
FT   ACT_SITE    244    244       By similarity.
FT   ACT_SITE    278    278       By similarity.
SQ   SEQUENCE   487 AA;  51087 MW;  86BBC29E8B4C2CC0 CRC64;
     MSTHYIAGQW RPGQGAPLQS LDPVSQAVVW QGQGASAAQV DEAVNAARGA FSLWAAHSLD
     GRIAVLERFA AALKSHADEL ARAIGEETGK PLWEAATEVT SMVNKVAISI QSYRERTGEK
     SGPLADATAV LRHKPHGVVA VFGPYNFPGH LPNGHIVPAL LAGNCVLFKP SELTPKVAEL
     TVKCWIEAGL PAGVLNLLQG GRETGVALAG HPGIDGLFFT GSSRTGNLLH AQFAGRPDKI
     LALEMGGNNP LIVDQVADID AAVYTIVQSA FISAGQRCTC ARRLLVPQGQ WGDALLARLV
     QVAGQLKVGR FDEQPAPFMG SVISLQAAAQ LMQAQADLLA KGATALLAMT QPQADAALLT
     PGILDVTAVS ERPDEEFFGP LLQVIRYSDF DGAIAEANTT AFGLAAGLLS DSKARYEQFW
     LHSRAGIVNW NKQLTGAAST APFGGIGASG NHRASAYYAA DYCAYPVASL ESEALTLPTT
     LTPGVTL
//