Reviewed, UniProtKB/Swiss-Prot A4XWE7 (ASTD_PSEMY)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	Pmen_2908

Organism

Pseudomonas mendocina (strain ymp) [Complete proteome] [HAMAP]

Taxonomic identifier

399739 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	487 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O = N-succinyl-L-glutamate + NADH.
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5.
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 487	487	N-succinylglutamate 5-semialdehyde dehydrogenase		PRO_1000065761
Regions
	Nucleotide binding	221 – 226	6	NAD By similarity
Sites
	Active site	244	1	By similarity
	Active site	278	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4XWE7-1 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: 86BBC29E8B4C2CC0	FASTA	487	51,087
	10 20 30 40 50 60 MSTHYIAGQW RPGQGAPLQS LDPVSQAVVW QGQGASAAQV DEAVNAARGA FSLWAAHSLD 70 80 90 100 110 120 GRIAVLERFA AALKSHADEL ARAIGEETGK PLWEAATEVT SMVNKVAISI QSYRERTGEK 130 140 150 160 170 180 SGPLADATAV LRHKPHGVVA VFGPYNFPGH LPNGHIVPAL LAGNCVLFKP SELTPKVAEL 190 200 210 220 230 240 TVKCWIEAGL PAGVLNLLQG GRETGVALAG HPGIDGLFFT GSSRTGNLLH AQFAGRPDKI 250 260 270 280 290 300 LALEMGGNNP LIVDQVADID AAVYTIVQSA FISAGQRCTC ARRLLVPQGQ WGDALLARLV 310 320 330 340 350 360 QVAGQLKVGR FDEQPAPFMG SVISLQAAAQ LMQAQADLLA KGATALLAMT QPQADAALLT 370 380 390 400 410 420 PGILDVTAVS ERPDEEFFGP LLQVIRYSDF DGAIAEANTT AFGLAAGLLS DSKARYEQFW 430 440 450 460 470 480 LHSRAGIVNW NKQLTGAAST APFGGIGASG NHRASAYYAA DYCAYPVASL ESEALTLPTT LTPGVTL

References

[1]

"Complete sequence of Pseudomonas mendocina ymp." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Detter J.C., Bruce D., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Mikhailova N., Hersman L., Dubois J., Maurice P., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000680 Genomic DNA. Translation: ABP85663.1.
RefSeq	YP_001188395.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5107626.
GenomeReviews	Gene locus Pmen_2908 in contig CP000680_GR.
KEGG	pmy:Pmen_2908.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_01174. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_PSEMY

Accession

Primary (citable) accession number: A4XWE7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	May 29, 2007
Last modified:	November 25, 2008
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)