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Protein

Succinylglutamate desuccinylase

Gene

astE

Organism
Pseudomonas mendocina (strain ymp)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transforms N2-succinylglutamate into succinate and glutamate.UniRule annotation

Catalytic activityi

N-succinyl-L-glutamate + H2O = succinate + L-glutamate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-arginine degradation via AST pathway

This protein is involved in step 5 of the subpathway that synthesizes L-glutamate and succinate from L-arginine.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Arginine N-succinyltransferase (Pmen_2909), Arginine N-succinyltransferase (Pmen_2910)
  2. N-succinylarginine dihydrolase (astB)
  3. no protein annotated in this organism
  4. N-succinylglutamate 5-semialdehyde dehydrogenase (astD)
  5. Succinylglutamate desuccinylase (astE)
This subpathway is part of the pathway L-arginine degradation via AST pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate and succinate from L-arginine, the pathway L-arginine degradation via AST pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59ZincUniRule annotation1
Metal bindingi62ZincUniRule annotation1
Metal bindingi152ZincUniRule annotation1
Active sitei216UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processArginine metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciPMEN399739:G1G8Q-2976-MONOMER.
UniPathwayiUPA00185; UER00283.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinylglutamate desuccinylaseUniRule annotation (EC:3.5.1.96UniRule annotation)
Gene namesi
Name:astEUniRule annotation
Ordered Locus Names:Pmen_2905
OrganismiPseudomonas mendocina (strain ymp)
Taxonomic identifieri399739 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000229 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000173251 – 337Succinylglutamate desuccinylaseAdd BLAST337

Proteomic databases

PRIDEiA4XWE4.

Interactioni

Protein-protein interaction databases

STRINGi399739.Pmen_2905.

Structurei

3D structure databases

ProteinModelPortaliA4XWE4.
SMRiA4XWE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107UI5. Bacteria.
COG2988. LUCA.
HOGENOMiHOG000280300.
KOiK05526.
OMAiAHAFTVE.
OrthoDBiPOG091H04VJ.

Family and domain databases

CDDicd03855. M14_ASTE. 1 hit.
HAMAPiMF_00767. Arg_catab_AstE. 1 hit.
InterProiView protein in InterPro
IPR007036. Aste_AspA.
IPR016681. SuccinylGlu_desuccinylase.
PfamiView protein in Pfam
PF04952. AstE_AspA. 1 hit.
PIRSFiPIRSF017020. AstE. 1 hit.
TIGRFAMsiTIGR03242. arg_catab_astE. 1 hit.

Sequencei

Sequence statusi: Complete.

A4XWE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALGKLLEL TLAGHEPSAK IQLTPDGTRL RWLDEGALEI TPPAARDNGL
60 70 80 90 100
DLLLSAGIHG NETAPIELLD RLLRGIARNE LHPAARILFL FGNPEAMRRG
110 120 130 140 150
ERFVEQDINR LFNGRHEQSS GFEAIRACDL EHLAATFFGK DTGRTRLHYD
160 170 180 190 200
LHTAIRGSKI EQFALYPWHE GRTHSRRELQ RLRAAGIEAV LLQNKGSITF
210 220 230 240 250
SSYTYGQLGA EAFTLELGKA RAFGQNQLVN LDLLENALQA LIEGREVIDD
260 270 280 290 300
EPTLDGLQLF AVSREIIKHS DSFQLHLPAD IENFTELEPG YLLAEDIADT
310 320 330
RWVVEEQNAR IIFPNPKVKN GLRAGILIVP DDGAGLA
Length:337
Mass (Da):37,486
Last modified:May 29, 2007 - v1
Checksum:i00A84E1EB784346A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000680 Genomic DNA. Translation: ABP85660.1.
RefSeqiWP_012019087.1. NC_009439.1.

Genome annotation databases

EnsemblBacteriaiABP85660; ABP85660; Pmen_2905.
GeneIDi5107623.
KEGGipmy:Pmen_2905.
PATRICifig|399739.8.peg.2944.

Similar proteinsi

Entry informationi

Entry nameiASTE_PSEMY
AccessioniPrimary (citable) accession number: A4XWE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: February 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome