A4XVB1 (MSRB_PSEMY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrB
EC=1.8.4.12

Alternative name(s):
Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	Pmen_2521

Organism

Pseudomonas mendocina (strain ymp) [Complete proteome] [HAMAP]

Taxonomic identifier

399739 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Cofactor	Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein By similarity.
Sequence similarities	Belongs to the MsrB Met sulfoxide reductase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 131	131	Peptide methionine sulfoxide reductase MsrB HAMAP MF_01400		PRO_1000068286
Sites
	Active site	119	1	Nucleophile By similarity
	Metal binding	47	1	Zinc By similarity
	Metal binding	50	1	Zinc By similarity
	Metal binding	96	1	Zinc By similarity
	Metal binding	99	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4XVB1 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: 2DAA0C9BA507E0C2	FASTA	131	14,711
	10 20 30 40 50 60 MDKVDKSLDT WREELTDEQF HVCRLGGTER PFTGAYHDSK TPGIYHCACC GEALFDSDAK 70 80 90 100 110 120 YDSGSGWPSY FQPINDEVIA SLDDYSHGMH RIEVKCAKCD AHLGHVFPDG PRPTGLRYCI 130 NSLSLKLVPR D

References

[1]

"Complete sequence of Pseudomonas mendocina ymp." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Detter J.C., Bruce D., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Mikhailova N., Hersman L., Dubois J., Maurice P., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ymp.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000680 Genomic DNA. Translation: ABP85277.1.
RefSeq	YP_001188009.1. NC_009439.1.
3D structure databases
ProteinModelPortal	A4XVB1.
SMR	A4XVB1. Positions 12-127.
ModBase	Search...
Protein-protein interaction databases
STRING	A4XVB1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5107988.
GenomeReviews	Gene locus Pmen_2521 in contig CP000680_GR.
KEGG	pmy:Pmen_2521.
PATRIC	19911586. VBIPseMen131592_2547.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0229.
HOGENOM	HBG715255.
OMA	APLFRSD.
PhylomeDB	A4XVB1.
ProtClustDB	PRK00222.
Enzyme and pathway databases
BioCyc	PMEN399739:PMEN_2521-MONOMER.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
KO	K07305.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
SUPFAM	SSF51316. Mss4_like. 1 hit.
TIGRFAMs	TIGR00357. TIGR00357. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_PSEMY

Accession

Primary (citable) accession number: A4XVB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	May 29, 2007
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program