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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Pmen_2397

Organism
Pseudomonas mendocina (strain ymp)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei146 – 1461SubstrateUniRule annotation
Sitei255 – 2551Critical for catalysisUniRule annotation
Metal bindingi350 – 3501Magnesium or manganeseUniRule annotation
Sitei420 – 4201Critical for catalysisUniRule annotation
Binding sitei547 – 5471SubstrateUniRule annotation
Metal bindingi548 – 5481Magnesium or manganeseUniRule annotation
Metal bindingi552 – 5521Magnesium or manganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciPMEN399739:GHR6-2441-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Pmen_2397Imported
OrganismiPseudomonas mendocina (strain ymp)Imported
Taxonomic identifieri399739 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000229 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi399739.Pmen_2397.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 1408Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiNSGQMWG.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

A4XUY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTPSKIIYT FTDEAPALAT YSLLPIVEAF AASADISVET RDISLAGRIL
60 70 80 90 100
ASFADRLDAD KRIDDDLAKL AELTLQPDAN IIKLPNISAS VPQLKAAIAE
110 120 130 140 150
LQAQGYNIPD FPEDPQSEED KEVRARYAKV LGSAVNPVLR EGNSDRRAPA
160 170 180 190 200
AVKAYARKHP HSMGKWSMAS QSHADYMRGG DFFSSEQSIT MAKAGDVRIE
210 220 230 240 250
FVGKDGKVEV KKQLALQEGE VFDSMFMSCR KLRDFFEKTL QDCKETGVMW
260 270 280 290 300
SLHVKATMMK VSHPIVFGHA VSVYYKDVFD KYGELFKELG VNPNNGISSV
310 320 330 340 350
YDKIKALPAS QQEEILHDIH EVYSHRPEMA MVDSVKGITN LHIPSDVIVD
360 370 380 390 400
ASMPAMIRNS GQMWGKDGKQ KDTKAVMPES TYARIYQEMI NFCKTNGAFD
410 420 430 440 450
PTTMGSVPNV GLMAQKAEEY GSHDKTFEMT ADGTMRVVAA DGTVLMQHQV
460 470 480 490 500
EAGDIWRACQ TKDAPIRDWV KLAVTRARQS NTPAIFWLDP ERAHDRELQK
510 520 530 540 550
KVELYLKDHD LTGLDIRMMG YNEAIRVSME RMIRGLDTIS VTGNVLRDYL
560 570 580 590 600
TDLFPIMELG TSAKMLSIVP LMAGGGMYET GAGGSAPKHV QQLVEENYLR
610 620 630 640 650
WDSLGEFLAL AVSLEETGIK TNNAKAKVLG KTLDQATGKL LDNNKSPARK
660 670 680 690 700
VGEIDNRGSH FYLALYWAQA LAEQNDDAEL KAHFAPLAKQ LTEQEATIVG
710 720 730 740
ELAAVQGKPV DIGGYYRSNP ELTSQVMRPS ATFNAALAAL NA
Length:742
Mass (Da):81,923
Last modified:May 29, 2007 - v1
Checksum:i0AF83F12B252FA9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000680 Genomic DNA. Translation: ABP85153.1.
RefSeqiWP_012018716.1. NC_009439.1.
YP_001187885.1. NC_009439.1.

Genome annotation databases

EnsemblBacteriaiABP85153; ABP85153; Pmen_2397.
GeneIDi5108237.
KEGGipmy:Pmen_2397.
PATRICi19911329. VBIPseMen131592_2419.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000680 Genomic DNA. Translation: ABP85153.1.
RefSeqiWP_012018716.1. NC_009439.1.
YP_001187885.1. NC_009439.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399739.Pmen_2397.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP85153; ABP85153; Pmen_2397.
GeneIDi5108237.
KEGGipmy:Pmen_2397.
PATRICi19911329. VBIPseMen131592_2419.

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiNSGQMWG.
OrthoDBiEOG6DVJPP.

Enzyme and pathway databases

BioCyciPMEN399739:GHR6-2441-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ympImported.

Entry informationi

Entry nameiA4XUY7_PSEMY
AccessioniPrimary (citable) accession number: A4XUY7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: April 29, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.