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A4XS60

- PNCB_PSEMY

UniProt

A4XS60 - PNCB_PSEMY

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Protein

Nicotinate phosphoribosyltransferase

Gene
pncB, Pmen_1411
Organism
Pseudomonas mendocina (strain ymp)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciPMEN399739:GHR6-1431-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:pncB
Ordered Locus Names:Pmen_1411
OrganismiPseudomonas mendocina (strain ymp)
Taxonomic identifieri399739 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000229: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Nicotinate phosphoribosyltransferaseUniRule annotationPRO_1000025005Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399739.Pmen_1411.

Structurei

3D structure databases

ProteinModelPortaliA4XS60.
SMRiA4XS60. Positions 1-397.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiSIVCKVI.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

A4XS60-1 [UniParc]FASTAAdd to Basket

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MSESIFAERI VQNLLDTDFY KLTMMQAVLH NYPNAEVEWE FRCRSSEDLT    50
PYLAEIRYQI ERLSELSITA DQLAFLERIP FIKPDFIRFL SLFRFNLRYV 100
HTGIEDGQLS IRLRGPWLHV ILFEVPLLAI VSEVRNRYRY REVLLEQAAE 150
RLYQKLDWLR AEASEDELAG FQLADFGTRR RFSYRVQEQA VHILKRDFPG 200
RFVGTSNVHL AREFDLKPIG TMAHEWLMAH QQLGPRLIDS QIAALDCWVR 250
EYRGQLGIAL TDCITMDAFL ADFDLYFAKL FDGLRHDSGD PLEWAEKAIA 300
HYEKLGIDPL SKTLVFSDGL DLPKSLRLYR ALSGRIHVSF GVGTNLTCDI 350
PGVEPMNIVI KMIACNGQPV AKISDTPGKT QCRDENFVSY LKHVFRVTQ 399
Length:399
Mass (Da):46,144
Last modified:May 29, 2007 - v1
Checksum:iEE5E44EAD3336723
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000680 Genomic DNA. Translation: ABP84176.1.
RefSeqiWP_012017995.1. NC_009439.1.
YP_001186908.1. NC_009439.1.

Genome annotation databases

EnsemblBacteriaiABP84176; ABP84176; Pmen_1411.
GeneIDi5109700.
KEGGipmy:Pmen_1411.
PATRICi19909307. VBIPseMen131592_1432.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000680 Genomic DNA. Translation: ABP84176.1 .
RefSeqi WP_012017995.1. NC_009439.1.
YP_001186908.1. NC_009439.1.

3D structure databases

ProteinModelPortali A4XS60.
SMRi A4XS60. Positions 1-397.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399739.Pmen_1411.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP84176 ; ABP84176 ; Pmen_1411 .
GeneIDi 5109700.
KEGGi pmy:Pmen_1411.
PATRICi 19909307. VBIPseMen131592_1432.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
KOi K00763.
OMAi SIVCKVI.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci PMEN399739:GHR6-1431-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ymp.

Entry informationi

Entry nameiPNCB_PSEMY
AccessioniPrimary (citable) accession number: A4XS60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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