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A4XS60

- PNCB_PSEMY

UniProt

A4XS60 - PNCB_PSEMY

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Pseudomonas mendocina (strain ymp)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciPMEN399739:GHR6-1431-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:Pmen_1411
    OrganismiPseudomonas mendocina (strain ymp)
    Taxonomic identifieri399739 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000229: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 399399Nicotinate phosphoribosyltransferasePRO_1000025005Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi399739.Pmen_1411.

    Structurei

    3D structure databases

    ProteinModelPortaliA4XS60.
    SMRiA4XS60. Positions 1-397.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284928.
    KOiK00763.
    OMAiSIVCKVI.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4XS60-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSESIFAERI VQNLLDTDFY KLTMMQAVLH NYPNAEVEWE FRCRSSEDLT    50
    PYLAEIRYQI ERLSELSITA DQLAFLERIP FIKPDFIRFL SLFRFNLRYV 100
    HTGIEDGQLS IRLRGPWLHV ILFEVPLLAI VSEVRNRYRY REVLLEQAAE 150
    RLYQKLDWLR AEASEDELAG FQLADFGTRR RFSYRVQEQA VHILKRDFPG 200
    RFVGTSNVHL AREFDLKPIG TMAHEWLMAH QQLGPRLIDS QIAALDCWVR 250
    EYRGQLGIAL TDCITMDAFL ADFDLYFAKL FDGLRHDSGD PLEWAEKAIA 300
    HYEKLGIDPL SKTLVFSDGL DLPKSLRLYR ALSGRIHVSF GVGTNLTCDI 350
    PGVEPMNIVI KMIACNGQPV AKISDTPGKT QCRDENFVSY LKHVFRVTQ 399
    Length:399
    Mass (Da):46,144
    Last modified:May 29, 2007 - v1
    Checksum:iEE5E44EAD3336723
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000680 Genomic DNA. Translation: ABP84176.1.
    RefSeqiWP_012017995.1. NC_009439.1.
    YP_001186908.1. NC_009439.1.

    Genome annotation databases

    EnsemblBacteriaiABP84176; ABP84176; Pmen_1411.
    GeneIDi5109700.
    KEGGipmy:Pmen_1411.
    PATRICi19909307. VBIPseMen131592_1432.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000680 Genomic DNA. Translation: ABP84176.1 .
    RefSeqi WP_012017995.1. NC_009439.1.
    YP_001186908.1. NC_009439.1.

    3D structure databases

    ProteinModelPortali A4XS60.
    SMRi A4XS60. Positions 1-397.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399739.Pmen_1411.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP84176 ; ABP84176 ; Pmen_1411 .
    GeneIDi 5109700.
    KEGGi pmy:Pmen_1411.
    PATRICi 19909307. VBIPseMen131592_1432.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284928.
    KOi K00763.
    OMAi SIVCKVI.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci PMEN399739:GHR6-1431-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ymp.

    Entry informationi

    Entry nameiPNCB_PSEMY
    AccessioniPrimary (citable) accession number: A4XS60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3