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A4XQ60

- PUR9_PSEMY

UniProt

A4XQ60 - PUR9_PSEMY

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Pseudomonas mendocina (strain ymp)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciPMEN399739:GHR6-709-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Pmen_0708
OrganismiPseudomonas mendocina (strain ymp)
Taxonomic identifieri399739 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000229: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 535535Bifunctional purine biosynthesis protein PurHPRO_1000018940Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399739.Pmen_0708.

Structurei

3D structure databases

ProteinModelPortaliA4XQ60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A4XQ60-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDQTTRLPV RRALISVSDK TGILEFAREL SALGVEILST GGTYKLLKDN
60 70 80 90 100
GVAAVEVADY TGFPEMMDGR VKTLHPKIHG GILGRRALDG AVMDEHGIKP
110 120 130 140 150
IDLVAVNLYP FEATVAKPDC DLADAIENID IGGPTMVRSA AKNHKDVAIV
160 170 180 190 200
VNTGDYAGIV ESLKAGGLTY AQRFDLALKA FEHTAAYDGM IANYLGTIDL
210 220 230 240 250
AADTLSTEGR GAFPRTFNSQ FIKAQEMRYG ENPHQSAAFY VEAKKGEASV
260 270 280 290 300
STAIQLQGKE LSFNNVADTD AALECVKSFV KPACVIVKHA NPCGVAVVPE
310 320 330 340 350
DEGGIRKAYD LAYATDTESA FGGIIAFNRE LDGETAKAIV ERQFVEVIIA
360 370 380 390 400
PKISAAAREV VAAKANVRLL ECGEWSAERA AGWDFKRVNG GLLVQSRDIG
410 420 430 440 450
MIKAEDLKIV TQRAPSEQEI HDLIFAWKVA KFVKSNAIVY AKNRQTVGVG
460 470 480 490 500
AGQMSRVNSA RIAAIKAEHA GLQVQGAVMA SDAFFPFRDG IDNAAKAGIT
510 520 530
AVIQPGGSMR DAEVIAAADE AGIAMVFTGM RHFRH
Length:535
Mass (Da):57,246
Last modified:May 29, 2007 - v1
Checksum:i738D1C8F000561C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000680 Genomic DNA. Translation: ABP83476.1.
RefSeqiWP_011920888.1. NC_009439.1.
YP_001186208.1. NC_009439.1.

Genome annotation databases

EnsemblBacteriaiABP83476; ABP83476; Pmen_0708.
GeneIDi5109038.
KEGGipmy:Pmen_0708.
PATRICi19907844. VBIPseMen131592_0718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000680 Genomic DNA. Translation: ABP83476.1 .
RefSeqi WP_011920888.1. NC_009439.1.
YP_001186208.1. NC_009439.1.

3D structure databases

ProteinModelPortali A4XQ60.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399739.Pmen_0708.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP83476 ; ABP83476 ; Pmen_0708 .
GeneIDi 5109038.
KEGGi pmy:Pmen_0708.
PATRICi 19907844. VBIPseMen131592_0718.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci PMEN399739:GHR6-709-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ymp.

Entry informationi

Entry nameiPUR9_PSEMY
AccessioniPrimary (citable) accession number: A4XQ60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: November 26, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3