Reviewed, UniProtKB/Swiss-Prot A4XPI6 (BETB_PSEMY)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	Pmen_0482

Organism

Pseudomonas mendocina (strain ymp) [Complete proteome] [HAMAP]

Taxonomic identifier

399739 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Betaine aldehyde dehydrogenase		PRO_1000047048
Regions
	Nucleotide binding	229 – 234	6	NAD By similarity
Sites
	Active site	252	1	By similarity
	Active site	286	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4XPI6-1 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: D0DE6E4DE8909B18	FASTA	490	53,122
	10 20 30 40 50 60 MPRFAEQQLY IGGQYVAASS GQTFDSINPA TGEVLAKVQR ASQADVDRAV ASAAEGQKVW 70 80 90 100 110 120 AAMTAMQRSR ILRRAVDILR ERNDELAELE TLDTGKPLSE TRYVDIVTGA DVLEYYAGLI 130 140 150 160 170 180 PAIEGEQIPL RESSFVYTRR EPLGVVAGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSEV 190 200 210 220 230 240 TSLTALKLAE IYTEAGLPAG VFNVLTGSGR EVGQWLTEHP GIEKVSFTGG TVTGKKVMAS 250 260 270 280 290 300 ASSSSLKEVT MELGGKSPLI VFEDADLDRA ADIAVMANFY SSGQVCTNGT RVFVPRMLQA 310 320 330 340 350 360 RFEAKVLERV KRIRLGDPLD DATNFGPLVS YAHMESVLGY IEKGRSEGAR LLIGGTRVSD 370 380 390 400 410 420 GDYAKGAYVA PTVFTDCRDD MTIVREEIFG PVMSILIYDS EEEVIRRAND TDYGLAAGVV 430 440 450 460 470 480 TRDLNRAHRV IHKLEAGICW INTWGESPAE MPVGGYKQSG VGRENGLVTL GHYTRIKSVQ 490 VELGGYSSVF

References

[1]

"Complete sequence of Pseudomonas mendocina ymp." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Detter J.C., Bruce D., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Mikhailova N., Hersman L., Dubois J., Maurice P., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000680 Genomic DNA. Translation: ABP83252.1.
RefSeq	YP_001185984.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5108401.
GenomeReviews	Gene locus Pmen_0482 in contig CP000680_GR.
KEGG	pmy:Pmen_0482.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR011264. Betaine_Ald_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_PSEMY

Accession

Primary (citable) accession number: A4XPI6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 29, 2007
Last modified:	November 4, 2008
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)