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A4XPI6

- BETB_PSEMY

UniProt

A4XPI6 - BETB_PSEMY

Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Pseudomonas mendocina (strain ymp)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

    Catalytic activityi

    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    Binds 2 potassium ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi26 – 261Potassium 1UniRule annotation
    Metal bindingi27 – 271Potassium 1; via carbonyl oxygenUniRule annotation
    Metal bindingi93 – 931Potassium 1UniRule annotation
    Active sitei162 – 1621Charge relay systemUniRule annotation
    Metal bindingi180 – 1801Potassium 1; via carbonyl oxygenUniRule annotation
    Binding sitei209 – 2091NAD/NADP; via amide nitrogenUniRule annotation
    Metal bindingi246 – 2461Potassium 2; via carbonyl oxygenUniRule annotation
    Sitei248 – 2481Seems to be a necessary countercharge to the potassium cationsUniRule annotation
    Active sitei252 – 2521Proton acceptorUniRule annotation
    Binding sitei286 – 2861NAD/NADPUniRule annotation
    Binding sitei387 – 3871NAD/NADPUniRule annotation
    Metal bindingi457 – 4571Potassium 2; via carbonyl oxygenUniRule annotation
    Metal bindingi460 – 4601Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei464 – 4641Charge relay systemUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi150 – 1534NAD/NADPUniRule annotation
    Nucleotide bindingi176 – 1794NAD/NADPUniRule annotation
    Nucleotide bindingi229 – 2346NAD/NADPUniRule annotation

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, NADP, Potassium

    Enzyme and pathway databases

    BioCyciPMEN399739:GHR6-482-MONOMER.
    UniPathwayiUPA00529; UER00386.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betBUniRule annotation
    Ordered Locus Names:Pmen_0482
    OrganismiPseudomonas mendocina (strain ymp)
    Taxonomic identifieri399739 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000229: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490NAD/NADP-dependent betaine aldehyde dehydrogenasePRO_1000047048Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei286 – 2861Cysteine sulfenic acid (-SOH)UniRule annotation

    Keywords - PTMi

    Oxidation

    Interactioni

    Subunit structurei

    Dimer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi399739.Pmen_0482.

    Structurei

    3D structure databases

    ProteinModelPortaliA4XPI6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00130.
    OMAiRANGTHL.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPiMF_00804. BADH.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR01804. BADH. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4XPI6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRFAEQQLY IGGQYVAASS GQTFDSINPA TGEVLAKVQR ASQADVDRAV    50
    ASAAEGQKVW AAMTAMQRSR ILRRAVDILR ERNDELAELE TLDTGKPLSE 100
    TRYVDIVTGA DVLEYYAGLI PAIEGEQIPL RESSFVYTRR EPLGVVAGIG 150
    AWNYPIQIAL WKSAPALAAG NAMIFKPSEV TSLTALKLAE IYTEAGLPAG 200
    VFNVLTGSGR EVGQWLTEHP GIEKVSFTGG TVTGKKVMAS ASSSSLKEVT 250
    MELGGKSPLI VFEDADLDRA ADIAVMANFY SSGQVCTNGT RVFVPRMLQA 300
    RFEAKVLERV KRIRLGDPLD DATNFGPLVS YAHMESVLGY IEKGRSEGAR 350
    LLIGGTRVSD GDYAKGAYVA PTVFTDCRDD MTIVREEIFG PVMSILIYDS 400
    EEEVIRRAND TDYGLAAGVV TRDLNRAHRV IHKLEAGICW INTWGESPAE 450
    MPVGGYKQSG VGRENGLVTL GHYTRIKSVQ VELGGYSSVF 490
    Length:490
    Mass (Da):53,122
    Last modified:May 29, 2007 - v1
    Checksum:iD0DE6E4DE8909B18
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000680 Genomic DNA. Translation: ABP83252.1.
    RefSeqiWP_011920719.1. NC_009439.1.
    YP_001185984.1. NC_009439.1.

    Genome annotation databases

    EnsemblBacteriaiABP83252; ABP83252; Pmen_0482.
    GeneIDi5108401.
    KEGGipmy:Pmen_0482.
    PATRICi19907384. VBIPseMen131592_0491.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000680 Genomic DNA. Translation: ABP83252.1 .
    RefSeqi WP_011920719.1. NC_009439.1.
    YP_001185984.1. NC_009439.1.

    3D structure databases

    ProteinModelPortali A4XPI6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399739.Pmen_0482.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP83252 ; ABP83252 ; Pmen_0482 .
    GeneIDi 5108401.
    KEGGi pmy:Pmen_0482.
    PATRICi 19907384. VBIPseMen131592_0491.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00130.
    OMAi RANGTHL.
    OrthoDBi EOG6BS8QW.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00386 .
    BioCyci PMEN399739:GHR6-482-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPi MF_00804. BADH.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR01804. BADH. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ymp.

    Entry informationi

    Entry nameiBETB_PSEMY
    AccessioniPrimary (citable) accession number: A4XPI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3