ID   BETA_PSEMY              Reviewed;         565 AA.
AC   A4XPI5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   16-JUN-2009, entry version 14.
DE   RecName: Full=Choline dehydrogenase;
DE            Short=CHD;
DE            Short=CDH;
DE            EC=1.1.99.1;
GN   Name=betA; OrderedLocusNames=Pmen_0481;
OS   Pseudomonas mendocina (strain ymp).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=399739;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Detter J.C.,
RA   Bruce D., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Hersman L., Dubois J., Maurice P.,
RA   Richardson P.;
RT   "Complete sequence of Pseudomonas mendocina ymp.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Can catalyze the oxidation of choline to betaine
CC       aldehyde and betaine aldehyde to glycine betaine (By similarity).
CC   -!- CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde +
CC       reduced acceptor.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine aldehyde from choline (cytochrome c
CC       reductase route): step 1/1.
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
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DR   EMBL; CP000680; ABP83251.1; -; Genomic_DNA.
DR   RefSeq; YP_001185983.1; -.
DR   GeneID; 5108400; -.
DR   GenomeReviews; CP000680_GR; Pmen_0481.
DR   KEGG; pmy:Pmen_0481; -.
DR   OMA; A4XPI5; GRRMECG.
DR   GO; GO:0008812; F:choline dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0006066; P:cellular alcohol metabolic process; IEA:InterPro.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00750; -; 1.
DR   InterPro; IPR011533; Choline_dehydrogenase.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   TIGRFAMs; TIGR01810; betA; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; FAD; Flavoprotein; Oxidoreductase.
FT   CHAIN         1    565       Choline dehydrogenase.
FT                                /FTId=PRO_1000046569.
FT   NP_BIND       6     35       FAD (Probable).
FT   ACT_SITE    475    475       By similarity.
SQ   SEQUENCE   565 AA;  62252 MW;  AAFF3254370B986D CRC64;
     MSHEFDYIII GAGSAGNVLA TRLTEDADVS VLLLEAGGPD YRLDFRTQMP AALAFPLQGR
     RYNWAYETDP EPHMNNRRME CGRGKGLGGS SLINGMCYIR GNALDFDNWA KAKGLEDWTY
     HDCLPYFRKA ESRDIGPNDY HGGDGPVSVT TPKAGNNPLF HAMVEAGVQA GYPRTDDLNG
     YQQEGFGPMD RTVTPQGRRA STARGYLDQA RERPNLTIVT HATTDRILFD GKRASGVSYL
     IGNANDATEA RARREVLLCA GAIASPQILQ RSGVGPAALL RELDIALVHE LPGVGQNLQD
     HLEMYLQYAC TQPVSLYPAL KLLNQPGIGA QWLFTGNGIG ASNQFEAGGF IRTRPEFAWP
     NIQFHFLPVA INYNGSNAVN EHGFQAHVGS MRSPSRGRIQ LKSKDPRQHP SILFNYMSHE
     QDWQEFRDAI RITREIMAQP ALDSYRGREI SPGIDCQSDA ELDAFIREHA ETAFHPSCSC
     KMGEDDMAVV DGQGRVHGVQ GLRVVDASIM PEIITGNLNA TTIMMAEKIA DRIRDRQPLP
     RSNAPYFVAG ERPVRGQPQR AVSAA
//