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A4XPI5 (BETA_PSEMY) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Choline dehydrogenase
Short name=CDH
Short name=CHD
EC=1.1.99.1
Gene names
Name:betA
Ordered Locus Names:Pmen_0481
OrganismPseudomonas mendocina (strain ymp) [Complete proteome] [HAMAP]
Taxonomic identifier399739 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length565 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750

Cofactor

FAD By similarity. HAMAP MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 565565Choline dehydrogenase HAMAP MF_00750
PRO_1000046569

Regions

Nucleotide binding6 – 3530FAD Potential

Sites

Active site4751 By similarity

Sequences

Sequence LengthMass (Da)Tools
A4XPI5 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: AAFF3254370B986D

FASTA56562,252
        10         20         30         40         50         60 
MSHEFDYIII GAGSAGNVLA TRLTEDADVS VLLLEAGGPD YRLDFRTQMP AALAFPLQGR 

        70         80         90        100        110        120 
RYNWAYETDP EPHMNNRRME CGRGKGLGGS SLINGMCYIR GNALDFDNWA KAKGLEDWTY 

       130        140        150        160        170        180 
HDCLPYFRKA ESRDIGPNDY HGGDGPVSVT TPKAGNNPLF HAMVEAGVQA GYPRTDDLNG 

       190        200        210        220        230        240 
YQQEGFGPMD RTVTPQGRRA STARGYLDQA RERPNLTIVT HATTDRILFD GKRASGVSYL 

       250        260        270        280        290        300 
IGNANDATEA RARREVLLCA GAIASPQILQ RSGVGPAALL RELDIALVHE LPGVGQNLQD 

       310        320        330        340        350        360 
HLEMYLQYAC TQPVSLYPAL KLLNQPGIGA QWLFTGNGIG ASNQFEAGGF IRTRPEFAWP 

       370        380        390        400        410        420 
NIQFHFLPVA INYNGSNAVN EHGFQAHVGS MRSPSRGRIQ LKSKDPRQHP SILFNYMSHE 

       430        440        450        460        470        480 
QDWQEFRDAI RITREIMAQP ALDSYRGREI SPGIDCQSDA ELDAFIREHA ETAFHPSCSC 

       490        500        510        520        530        540 
KMGEDDMAVV DGQGRVHGVQ GLRVVDASIM PEIITGNLNA TTIMMAEKIA DRIRDRQPLP 

       550        560 
RSNAPYFVAG ERPVRGQPQR AVSAA

« Hide

References

[1]"Complete sequence of Pseudomonas mendocina ymp."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Detter J.C., Bruce D., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Mikhailova N., Hersman L., Dubois J., Maurice P., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ymp.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000680 Genomic DNA. Translation: ABP83251.1.
RefSeqYP_001185983.1. NC_009439.1.

3D structure databases

ProteinModelPortalA4XPI5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4XPI5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5108400.
GenomeReviewsGene locus Pmen_0481 in contig CP000680_GR.
KEGGpmy:Pmen_0481.
PATRIC19907382. VBIPseMen131592_0490.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2303.
HOGENOMHBG734713.
OMAEISPGAH.
PhylomeDBA4XPI5.
ProtClustDBPRK02106.

Enzyme and pathway databases

BioCycPMEN399739:PMEN_0481-MONOMER.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
[Tree]
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
KOK00108.
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. BetA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_PSEMY
AccessionPrimary (citable) accession number: A4XPI5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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