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A4XPI5

- BETA_PSEMY

UniProt

A4XPI5 - BETA_PSEMY

Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Pseudomonas mendocina (strain ymp)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

    Catalytic activityi

    Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei475 – 4751UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi6 – 3530FADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. choline dehydrogenase activity Source: UniProtKB-HAMAP
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciPMEN399739:GHR6-481-MONOMER.
    UniPathwayiUPA00529; UER00385.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
    Short name:
    CDHUniRule annotation
    Short name:
    CHDUniRule annotation
    Alternative name(s):
    Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betAUniRule annotation
    Ordered Locus Names:Pmen_0481
    OrganismiPseudomonas mendocina (strain ymp)
    Taxonomic identifieri399739 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000229: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 565565Oxygen-dependent choline dehydrogenasePRO_1000046569Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi399739.Pmen_0481.

    Structurei

    3D structure databases

    ProteinModelPortaliA4XPI5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GMC oxidoreductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2303.
    HOGENOMiHOG000139600.
    KOiK00108.
    OMAiYLQYACT.
    OrthoDBiEOG67HJQP.

    Family and domain databases

    HAMAPiMF_00750. Choline_dehydrogen.
    InterProiIPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view]
    PfamiPF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsiTIGR01810. betA. 1 hit.
    PROSITEiPS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4XPI5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHEFDYIII GAGSAGNVLA TRLTEDADVS VLLLEAGGPD YRLDFRTQMP    50
    AALAFPLQGR RYNWAYETDP EPHMNNRRME CGRGKGLGGS SLINGMCYIR 100
    GNALDFDNWA KAKGLEDWTY HDCLPYFRKA ESRDIGPNDY HGGDGPVSVT 150
    TPKAGNNPLF HAMVEAGVQA GYPRTDDLNG YQQEGFGPMD RTVTPQGRRA 200
    STARGYLDQA RERPNLTIVT HATTDRILFD GKRASGVSYL IGNANDATEA 250
    RARREVLLCA GAIASPQILQ RSGVGPAALL RELDIALVHE LPGVGQNLQD 300
    HLEMYLQYAC TQPVSLYPAL KLLNQPGIGA QWLFTGNGIG ASNQFEAGGF 350
    IRTRPEFAWP NIQFHFLPVA INYNGSNAVN EHGFQAHVGS MRSPSRGRIQ 400
    LKSKDPRQHP SILFNYMSHE QDWQEFRDAI RITREIMAQP ALDSYRGREI 450
    SPGIDCQSDA ELDAFIREHA ETAFHPSCSC KMGEDDMAVV DGQGRVHGVQ 500
    GLRVVDASIM PEIITGNLNA TTIMMAEKIA DRIRDRQPLP RSNAPYFVAG 550
    ERPVRGQPQR AVSAA 565
    Length:565
    Mass (Da):62,252
    Last modified:May 29, 2007 - v1
    Checksum:iAAFF3254370B986D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000680 Genomic DNA. Translation: ABP83251.1.
    RefSeqiWP_011920718.1. NC_009439.1.
    YP_001185983.1. NC_009439.1.

    Genome annotation databases

    EnsemblBacteriaiABP83251; ABP83251; Pmen_0481.
    GeneIDi5108400.
    KEGGipmy:Pmen_0481.
    PATRICi19907382. VBIPseMen131592_0490.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000680 Genomic DNA. Translation: ABP83251.1 .
    RefSeqi WP_011920718.1. NC_009439.1.
    YP_001185983.1. NC_009439.1.

    3D structure databases

    ProteinModelPortali A4XPI5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399739.Pmen_0481.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP83251 ; ABP83251 ; Pmen_0481 .
    GeneIDi 5108400.
    KEGGi pmy:Pmen_0481.
    PATRICi 19907382. VBIPseMen131592_0490.

    Phylogenomic databases

    eggNOGi COG2303.
    HOGENOMi HOG000139600.
    KOi K00108.
    OMAi YLQYACT.
    OrthoDBi EOG67HJQP.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00385 .
    BioCyci PMEN399739:GHR6-481-MONOMER.

    Family and domain databases

    HAMAPi MF_00750. Choline_dehydrogen.
    InterProi IPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view ]
    Pfami PF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsi TIGR01810. betA. 1 hit.
    PROSITEi PS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ymp.

    Entry informationi

    Entry nameiBETA_PSEMY
    AccessioniPrimary (citable) accession number: A4XPI5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3