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A4XPI5

- BETA_PSEMY

UniProt

A4XPI5 - BETA_PSEMY

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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Pseudomonas mendocina (strain ymp)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei475 – 4751UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 3530FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciPMEN399739:GHR6-481-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:Pmen_0481
OrganismiPseudomonas mendocina (strain ymp)
Taxonomic identifieri399739 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000229: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565Oxygen-dependent choline dehydrogenasePRO_1000046569Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399739.Pmen_0481.

Structurei

3D structure databases

ProteinModelPortaliA4XPI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4XPI5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHEFDYIII GAGSAGNVLA TRLTEDADVS VLLLEAGGPD YRLDFRTQMP
60 70 80 90 100
AALAFPLQGR RYNWAYETDP EPHMNNRRME CGRGKGLGGS SLINGMCYIR
110 120 130 140 150
GNALDFDNWA KAKGLEDWTY HDCLPYFRKA ESRDIGPNDY HGGDGPVSVT
160 170 180 190 200
TPKAGNNPLF HAMVEAGVQA GYPRTDDLNG YQQEGFGPMD RTVTPQGRRA
210 220 230 240 250
STARGYLDQA RERPNLTIVT HATTDRILFD GKRASGVSYL IGNANDATEA
260 270 280 290 300
RARREVLLCA GAIASPQILQ RSGVGPAALL RELDIALVHE LPGVGQNLQD
310 320 330 340 350
HLEMYLQYAC TQPVSLYPAL KLLNQPGIGA QWLFTGNGIG ASNQFEAGGF
360 370 380 390 400
IRTRPEFAWP NIQFHFLPVA INYNGSNAVN EHGFQAHVGS MRSPSRGRIQ
410 420 430 440 450
LKSKDPRQHP SILFNYMSHE QDWQEFRDAI RITREIMAQP ALDSYRGREI
460 470 480 490 500
SPGIDCQSDA ELDAFIREHA ETAFHPSCSC KMGEDDMAVV DGQGRVHGVQ
510 520 530 540 550
GLRVVDASIM PEIITGNLNA TTIMMAEKIA DRIRDRQPLP RSNAPYFVAG
560
ERPVRGQPQR AVSAA
Length:565
Mass (Da):62,252
Last modified:May 29, 2007 - v1
Checksum:iAAFF3254370B986D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000680 Genomic DNA. Translation: ABP83251.1.
RefSeqiWP_011920718.1. NC_009439.1.
YP_001185983.1. NC_009439.1.

Genome annotation databases

EnsemblBacteriaiABP83251; ABP83251; Pmen_0481.
GeneIDi5108400.
KEGGipmy:Pmen_0481.
PATRICi19907382. VBIPseMen131592_0490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000680 Genomic DNA. Translation: ABP83251.1 .
RefSeqi WP_011920718.1. NC_009439.1.
YP_001185983.1. NC_009439.1.

3D structure databases

ProteinModelPortali A4XPI5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399739.Pmen_0481.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP83251 ; ABP83251 ; Pmen_0481 .
GeneIDi 5108400.
KEGGi pmy:Pmen_0481.
PATRICi 19907382. VBIPseMen131592_0490.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci PMEN399739:GHR6-481-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ymp.

Entry informationi

Entry nameiBETA_PSEMY
AccessioniPrimary (citable) accession number: A4XPI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: November 26, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3