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Protein

Amino-acid acetyltransferase

Gene

argA

Organism
Pseudomonas mendocina (strain ymp)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Amino-acid acetyltransferase (argA), Arginine biosynthesis bifunctional protein ArgJ (argJ)
  2. Acetylglutamate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00106

Names & Taxonomyi

Protein namesi
Recommended name:
Amino-acid acetyltransferaseUniRule annotation (EC:2.3.1.1UniRule annotation)
Alternative name(s):
N-acetylglutamate synthaseUniRule annotation
Short name:
AGSUniRule annotation
Short name:
NAGSUniRule annotation
Gene namesi
Name:argAUniRule annotation
Ordered Locus Names:Pmen_0354
OrganismiPseudomonas mendocina (strain ymp)
Taxonomic identifieri399739 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000229 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000848181 – 432Amino-acid acetyltransferaseAdd BLAST432

Proteomic databases

PRIDEiA4XP61

Interactioni

Protein-protein interaction databases

STRINGi399739.Pmen_0354

Structurei

3D structure databases

ProteinModelPortaliA4XP61
SMRiA4XP61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini286 – 425N-acetyltransferaseUniRule annotationAdd BLAST140

Sequence similaritiesi

Belongs to the acetyltransferase family. ArgA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QZM Bacteria
COG0548 LUCA
COG1246 LUCA
HOGENOMiHOG000262225
KOiK14682
OMAiKRKYNWD
OrthoDBiPOG091H063W

Family and domain databases

CDDicd04237 AAK_NAGS-ABP, 1 hit
Gene3Di3.40.1160.10, 1 hit
HAMAPiMF_01105 N_acetyl_glu_synth, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR016181 Acyl_CoA_acyltransferase
IPR001048 Asp/Glu/Uridylate_kinase
IPR000182 GNAT_dom
IPR033719 NAGS_kin
IPR010167 NH2A_AcTrfase
PANTHERiPTHR30602 PTHR30602, 1 hit
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PF00583 Acetyltransf_1, 1 hit
PIRSFiPIRSF000423 ArgA, 1 hit
SUPFAMiSSF53633 SSF53633, 1 hit
SSF55729 SSF55729, 1 hit
TIGRFAMsiTIGR01890 N-Ac-Glu-synth, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

A4XP61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHDYVTWLRH ASPYINAHRD RTFVVMLPGE GIAHPNFANI VHDLVLLHSL
60 70 80 90 100
GVRLVLVHGS RPQIEARLAA RGLTPHFHRD LRITDAPTLE CVIDAVGQLR
110 120 130 140 150
IAIEARLSMD MAASPMQGSR LRLTSGNFVT ARPIGVLDGV DYHHTGEVRR
160 170 180 190 200
IDRKGINRQL DERSIVLLSP LGYSPTGEIF NLACEDVATR AAIDLGADKL
210 220 230 240 250
LLFGAEDGLL DEHGQLVREL RPQQVPAHLA RLGSNYQGEL LDAAAQACRG
260 270 280 290 300
GVGRSHIVSY ATDGALLSEL FTRTGNGTLV AQEQFESLRE ATIEDVGGLI
310 320 330 340 350
ELISPLEEQG ILVRRSREVL EREIEQFSIV EREGLIIACA ALYPIADSDC
360 370 380 390 400
GELACLAVNP DYRHGGRGDE LLARIEARAR AQGLKTLFVL TTRTAHWFRE
410 420 430
RGFEPSSVER MPAARASLYN YQRNSKVFEK AL
Length:432
Mass (Da):47,732
Last modified:May 29, 2007 - v1
Checksum:i24CB49A0AAA9381D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000680 Genomic DNA Translation: ABP83127.1
RefSeqiWP_004373235.1, NC_009439.1

Genome annotation databases

EnsemblBacteriaiABP83127; ABP83127; Pmen_0354
GeneIDi5108276
KEGGipmy:Pmen_0354
PATRICifig|399739.8.peg.363

Similar proteinsi

Entry informationi

Entry nameiARGA_PSEMY
AccessioniPrimary (citable) accession number: A4XP61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: June 20, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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