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A4XMY1 (HIS8_CALS8) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histidinol-phosphate aminotransferase
EC=2.6.1.9
Alternative name(s):
Imidazole acetol-phosphate transaminase
Gene names
Name:hisC
Ordered Locus Names:Csac_2697
OrganismCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903) [Complete proteome] [HAMAP]
Taxonomic identifier351627 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacterales Family III. Incertae Sedis › Caldicellulosiruptor

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023

Cofactor

Pyridoxal phosphate By similarity. HAMAP MF_01023

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023

Subunit structure

Homodimer By similarity. HAMAP MF_01023

Sequence similarities

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Histidinol-phosphate aminotransferase HAMAP MF_01023
PRO_0000319747

Amino acid modifications

Modified residue2211N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A4XMY1 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 4A90CD554DEC2BAB

FASTA35840,698
        10         20         30         40         50         60 
MFREVIRTIS PYIPGKPISE VKRELGLEKV IKLASNENPL GPSENVKKAI KESLDDLSLY 

        70         80         90        100        110        120 
PDGNCTELKL KLAKKLNVKP TQIIFGAGSD EITQLIASIF INPGDNSIMA RPSFPRYETV 

       130        140        150        160        170        180 
TKVMGGIPIE IPLKNYTHDL EEFSKHINER TRVIWICNPN NPTGTIVKKD ELYNFIKSVP 

       190        200        210        220        230        240 
SEIAVVVDQA YKEYIDDPEY PDAIHWLDEF KNLIVLQTFS KIYGLASLRI GYAIASEEII 

       250        260        270        280        290        300 
EKLNRVRPPF NVNHVAQIAA IAALDDQEHI EKAKELNKKS LEFFYKSFEE MKLPYIKSYG 

       310        320        330        340        350 
NFVMVDVTKD AVEVFKKLLL KGIIVRPGDI FDMPTYIRVT TGLESDNMEF IKALKEVL

« Hide

References

[1]"Genome sequence of the thermophilic hydrogen-producing bacterium Caldicellulosiruptor saccharolyticus DSM 8903."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., van de Werken H.J.G., Verhaart M.R.A., VanFossen A.L., Lewis D.L., Nichols J.D., Goorissen H.P., van Niel E.W.J., Stams F.J.M., Willquist K.U., Ward D.E., van der Oost J., Kelly R.M., Kengen S.M.W., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43494 / DSM 8903.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000679 Genomic DNA. Translation: ABP68266.1.
RefSeqYP_001181457.1. NC_009437.1.

3D structure databases

ProteinModelPortalA4XMY1.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4XMY1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5086703.
GenomeReviewsGene locus Csac_2697 in contig CP000679_GR.
KEGGcsc:Csac_2697.
PATRIC21255254. VBICalSac56748_2914.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0079.
HOGENOMHBG646350.
OMAECLDASE.
ProtClustDBPRK03158.

Family and domain databases

HAMAPMF_01023. HisC_aminotrans_2.
[Tree]
InterProIPR001176. ACC_synthase.
IPR004839. Aminotransferase_I/II.
IPR005861. HisP_aminotrans.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK00817.
PfamPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PRINTSPR00753. ACCSYNTHASE.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR01141. HisC. 1 hit.
PROSITEPS00599. AA_TRANSFER_CLASS_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHIS8_CALS8
AccessionPrimary (citable) accession number: A4XMY1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 29, 2007
Last modified: December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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