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A4XM19

- UPPP_CALS8

UniProt

A4XM19 - UPPP_CALS8

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciCSAC351627:GJ17-2433-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Csac_2376
    OrganismiCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
    Taxonomic identifieri351627 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
    ProteomesiUP000000256: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 264264Undecaprenyl-diphosphatasePRO_1000072890Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi351627.Csac_2376.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalUniRule annotationAdd
    BLAST
    Transmembranei40 – 6021HelicalUniRule annotationAdd
    BLAST
    Transmembranei79 – 9921HelicalUniRule annotationAdd
    BLAST
    Transmembranei112 – 13221HelicalUniRule annotationAdd
    BLAST
    Transmembranei141 – 16121HelicalUniRule annotationAdd
    BLAST
    Transmembranei182 – 20221HelicalUniRule annotationAdd
    BLAST
    Transmembranei214 – 23421HelicalUniRule annotationAdd
    BLAST
    Transmembranei242 – 26221HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiWFIIVAT.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4XM19-1 [UniParc]FASTAAdd to Basket

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    MSTFQAIFLG ILQGLGEFLP ISSSAHLIIF PWLFGWKEHS LVFDVALHLG    50
    TLLAVLVYFW RDYIEIIVKG ITQPKSDQGK LLWFIIVATI PGAGFGYFFE 100
    NIVENVFRKQ YLLIAVVLAV FGFILYYVDK TAKNKFTLSN MNILQAGLIG 150
    ILQAFALFPG ISRSGITMTT GLLLGLKKEA AAKFSFLMSA PIILGAGVVS 200
    LLKNIHDVSS QFSSFAIGFF TSAIVGFLAI HFLLDIVRKS GFKIFAYYRF 250
    LLAALILVVF LLRI 264
    Length:264
    Mass (Da):29,309
    Last modified:May 29, 2007 - v1
    Checksum:i05A328C6565B8AD6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000679 Genomic DNA. Translation: ABP67954.1.
    RefSeqiWP_011917880.1. NC_009437.1.
    YP_001181145.1. NC_009437.1.

    Genome annotation databases

    EnsemblBacteriaiABP67954; ABP67954; Csac_2376.
    GeneIDi5087278.
    KEGGicsc:Csac_2376.
    PATRICi21254544. VBICalSac56748_2561.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000679 Genomic DNA. Translation: ABP67954.1 .
    RefSeqi WP_011917880.1. NC_009437.1.
    YP_001181145.1. NC_009437.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351627.Csac_2376.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP67954 ; ABP67954 ; Csac_2376 .
    GeneIDi 5087278.
    KEGGi csc:Csac_2376.
    PATRICi 21254544. VBICalSac56748_2561.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi WFIIVAT.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci CSAC351627:GJ17-2433-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43494 / DSM 8903.

    Entry informationi

    Entry nameiUPPP_CALS8
    AccessioniPrimary (citable) accession number: A4XM19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3