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A4XM19 (UPPP_CALS8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Csac_2376
OrganismCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903) [Complete proteome] [HAMAP]
Taxonomic identifier351627 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 264264Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000072890

Regions

Transmembrane14 – 3421Helical; Potential
Transmembrane40 – 6021Helical; Potential
Transmembrane79 – 9921Helical; Potential
Transmembrane112 – 13221Helical; Potential
Transmembrane141 – 16121Helical; Potential
Transmembrane182 – 20221Helical; Potential
Transmembrane214 – 23421Helical; Potential
Transmembrane242 – 26221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A4XM19 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 05A328C6565B8AD6

FASTA26429,309
        10         20         30         40         50         60 
MSTFQAIFLG ILQGLGEFLP ISSSAHLIIF PWLFGWKEHS LVFDVALHLG TLLAVLVYFW 

        70         80         90        100        110        120 
RDYIEIIVKG ITQPKSDQGK LLWFIIVATI PGAGFGYFFE NIVENVFRKQ YLLIAVVLAV 

       130        140        150        160        170        180 
FGFILYYVDK TAKNKFTLSN MNILQAGLIG ILQAFALFPG ISRSGITMTT GLLLGLKKEA 

       190        200        210        220        230        240 
AAKFSFLMSA PIILGAGVVS LLKNIHDVSS QFSSFAIGFF TSAIVGFLAI HFLLDIVRKS 

       250        260 
GFKIFAYYRF LLAALILVVF LLRI 

« Hide

References

[1]"Genome sequence of the thermophilic hydrogen-producing bacterium Caldicellulosiruptor saccharolyticus DSM 8903."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., van de Werken H.J.G., Verhaart M.R.A., VanFossen A.L., Lewis D.L., Nichols J.D., Goorissen H.P., van Niel E.W.J., Stams F.J.M., Willquist K.U., Ward D.E., van der Oost J., Kelly R.M., Kengen S.M.W., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43494 / DSM 8903.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000679 Genomic DNA. Translation: ABP67954.1.
RefSeqYP_001181145.1. NC_009437.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING351627.Csac_2376.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP67954; ABP67954; Csac_2376.
GeneID5087278.
KEGGcsc:Csac_2376.
PATRIC21254544. VBICalSac56748_2561.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAWFIIVAT.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycCSAC351627:GJ17-2433-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_CALS8
AccessionPrimary (citable) accession number: A4XM19
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families