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Protein

Anthranilate phosphoribosyltransferase

Gene

trpD

Organism
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (Csac_2233)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801Anthranilate 1; via carbonyl oxygenUniRule annotation
Binding sitei80 – 801Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation
Binding sitei88 – 881PhosphoribosylpyrophosphateUniRule annotation
Metal bindingi92 – 921Magnesium 1UniRule annotation
Binding sitei111 – 1111Anthranilate 1UniRule annotation
Binding sitei120 – 1201Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation
Binding sitei166 – 1661Anthranilate 2UniRule annotation
Metal bindingi224 – 2241Magnesium 2UniRule annotation
Metal bindingi225 – 2251Magnesium 1UniRule annotation
Metal bindingi225 – 2251Magnesium 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciCSAC351627:GJ17-2283-MONOMER.
UniPathwayiUPA00035; UER00041.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.18UniRule annotation)
Gene namesi
Name:trpDUniRule annotation
Ordered Locus Names:Csac_2234
OrganismiCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)
Taxonomic identifieri351627 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
Proteomesi
  • UP000000256 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Anthranilate phosphoribosyltransferasePRO_0000325419Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi351627.Csac_2234.

Structurei

3D structure databases

ProteinModelPortaliA4XLM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni83 – 842Phosphoribosylpyrophosphate bindingUniRule annotation
Regioni90 – 934Phosphoribosylpyrophosphate bindingUniRule annotation
Regioni108 – 1169Phosphoribosylpyrophosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108I0Q. Bacteria.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OMAiHSGQAYQ.
OrthoDBiPOG091H01QX.

Family and domain databases

Gene3Di3.40.1030.10. 2 hits.
HAMAPiMF_00211. TrpD. 1 hit.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.

Sequencei

Sequence statusi: Complete.

A4XLM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKEALEVVT AKRDLDYGQV KNLLDSILEG ELDEMKFGAF LAALKTKGET
60 70 80 90 100
KEEISAFVDA FYEKAQKIEY THPKTIDTCG TGGDGKGTFN ISTASAIVLS
110 120 130 140 150
CFDLKVAKHG NRSITSNSGS ADILENLGID IQAPPQRILE GLEKHNFAFL
160 170 180 190 200
FAPKYHPATK KVATVRKSLG IRTVFNILGP LLNPVSLNYQ VVGAFDFEAQ
210 220 230 240 250
EKIASVLKGK RKRAAIIHSL DGLDEISVSQ KTRVLELQGD NIKEYYIDPK
260 270 280 290 300
EYGIEYTLDD IKGYTPQENA KIFRSILNGE VSAYYWAVVL NSAFALYIAE
310 320 330
VANDIEEGIA LCQSAIKKGD AMLKLKDLQQ HYKVGA
Length:336
Mass (Da):37,050
Last modified:May 29, 2007 - v1
Checksum:i1F00A541B36EC84D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000679 Genomic DNA. Translation: ABP67812.1.
RefSeqiWP_011917738.1. NC_009437.1.

Genome annotation databases

EnsemblBacteriaiABP67812; ABP67812; Csac_2234.
KEGGicsc:Csac_2234.
PATRICi21254240. VBICalSac56748_2416.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000679 Genomic DNA. Translation: ABP67812.1.
RefSeqiWP_011917738.1. NC_009437.1.

3D structure databases

ProteinModelPortaliA4XLM7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi351627.Csac_2234.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP67812; ABP67812; Csac_2234.
KEGGicsc:Csac_2234.
PATRICi21254240. VBICalSac56748_2416.

Phylogenomic databases

eggNOGiENOG4108I0Q. Bacteria.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OMAiHSGQAYQ.
OrthoDBiPOG091H01QX.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.
BioCyciCSAC351627:GJ17-2283-MONOMER.

Family and domain databases

Gene3Di3.40.1030.10. 2 hits.
HAMAPiMF_00211. TrpD. 1 hit.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPD_CALS8
AccessioniPrimary (citable) accession number: A4XLM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 29, 2007
Last modified: September 7, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.