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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi485MagnesiumUniRule annotation1
Metal bindingi491MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciCSAC351627:G1G8P-2120-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Csac_2064
OrganismiCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)
Taxonomic identifieri351627 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
Proteomesi
  • UP000000256 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003295661 – 701Polyribonucleotide nucleotidyltransferaseAdd BLAST701

Proteomic databases

PRIDEiA4XL64

Interactioni

Protein-protein interaction databases

STRINGi351627.Csac_2064

Structurei

3D structure databases

ProteinModelPortaliA4XL64
SMRiA4XL64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini552 – 611KHUniRule annotationAdd BLAST60
Domaini621 – 689S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218327
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR036456 PNPase_PH_RNA-bd_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 1 hit
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF46915 SSF46915, 1 hit
SSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

A4XL64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKIYKMEL AGRELSFEIG KYALLANGAV LARYGDTAVL VTACASEKPR
60 70 80 90 100
EGINFFPLTV DYEERLYSVG KIPGGFIKRE GKPSEKAILS ARLIDRPIRP
110 120 130 140 150
LFPKDFYHDV SVIATVLSVD PDNPPDVLAM LGSSVALSIS DIPFEGPTGS
160 170 180 190 200
VLVGYVDGKI VINPTAKERE VSKLHLVVSG TKDKVMMIEA GAQEIPEDIM
210 220 230 240 250
LEAIMTAQEE IKKIVEFIEG IVKEVGKPKM QYEKRVVPEE IKQKVRELAY
260 270 280 290 300
EKAYQYVQIP DKIERDKKLD ELKEEVLKAF EGETEDTLLL VDDALYNLEK
310 320 330 340 350
EIVRKMIAEE GKRPDGRKFD EIRPLYAEVG ILPRTHGSAL FKRGYTQVLT
360 370 380 390 400
VATLGTKGEM QFLDGLEEEE AKRYMHHYNF PPYSTGESKP VRGPGRREIG
410 420 430 440 450
HGALAERALE PVIPSEDEFP YTIRLVSEVL TSNGSTSQAS VCGSTLALMD
460 470 480 490 500
AGVPIKAPVA GISIGLITKE DGSFITLTDI QGIEDFFGDM DFKVAGTREG
510 520 530 540 550
ITAIQLDIKI HGLTKEIIEK ALYQAREARL KILDFMQTVI DKPRSELSPY
560 570 580 590 600
APKIFKTTVD PEKIRDIIGP GGKMINKIIA KTNVKIDIEP DGRIFVAAPD
610 620 630 640 650
DISGNRAISM IEGIGREIEV GQFFLGKVTR TASYGAFVEI YPGKEGLVHI
660 670 680 690 700
SQLDNKKLKS VDEVVKVGDL VLVKVIGIDR LGRIALSRKE ALNVTYSRKA

K
Length:701
Mass (Da):77,604
Last modified:May 29, 2007 - v1
Checksum:i0C2117CA73945140
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000679 Genomic DNA Translation: ABP67649.1
RefSeqiWP_011917584.1, NC_009437.1

Genome annotation databases

EnsemblBacteriaiABP67649; ABP67649; Csac_2064
KEGGicsc:Csac_2064

Similar proteinsi

Entry informationi

Entry nameiPNP_CALS8
AccessioniPrimary (citable) accession number: A4XL64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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