Reviewed, UniProtKB/Swiss-Prot A4XL40 (ACKA_CALS8)

Names and origin

Protein names

Recommended name:
    Acetate kinase
    EC=2.7.2.1
Alternative name(s):
    Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	Csac_2040

Organism

Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903) [Complete proteome] [HAMAP]

Taxonomic identifier

351627 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacterales Family III. Incertae Sedis › Caldicellulosiruptor

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro phosphorylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 399	399	Acetate kinase HAMAP MF_00020		PRO_1000002212

Sequences

	Sequence		Length	Mass (Da)
	A4XL40-1 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: 557382A9712533BE	FASTA	399	44,558
	10 20 30 40 50 60 MKVLVLNSGS SSLKYQFIDT ETEVALCKGV VDRIGLPGAF IRHQKNGQEI IKEQEVKDHN 70 80 90 100 110 120 VAIKLVLEML THPQMGIIKS MDEIDAIGHR VVHGGEYFSD AVIVNEEVKK AIRECIEFAP 130 140 150 160 170 180 LHNPANLMGI EACEKEIPGK PNVAVFDTAF HQTMPKYAYM YSLPYEVYEK YKIRKYGFHG 190 200 210 220 230 240 TSHKYVAIKA AEYLKRPLKE LKLITCHLGN GSSVCAIKYG KSVDTSMGFT PLAGLAMGTR 250 260 270 280 290 300 SGTIDPAVIL YLMEKENMDV KQMNDLLNKK SGVLGISGVS SDFRDLEKAA NEGNERAQLA 310 320 330 340 350 360 IDMFCYRVKK YIGEYAAVLG GVDAIIFTAG IGENNPIVRE KCVTDLEYMG VLYDKQKNFN 370 380 390 AEKGKVFEIN KPESKVKVLI VPTNEELMIA RETKRLLEK

References

[1]

"Genome sequence of the thermophilic hydrogen-producing bacterium Caldicellulosiruptor saccharolyticus DSM 8903." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Lykidis A., van de Werken H.J.G., Verhaart M.R.A., VanFossen A.L., Lewis D.L., Nichols J.D., Goorissen H.P., van Niel E.W.J., Stams F.J.M., Willquist K.U., Ward D.E., van der Oost J., Kelly R.M., Kengen S.M.W., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000679 Genomic DNA. Translation: ABP67625.1.
RefSeq	YP_001180816.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5088517.
GenomeReviews	Gene locus Csac_2040 in contig CP000679_GR.
KEGG	csc:Csac_2040.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A4XL40. IDMEREV.
Family and domain databases
HAMAP	MF_00020. [Tree]
InterPro	IPR000890. Acetate_kin. IPR004372. AckA. [Graphical view]
PANTHER	PTHR21060. Acetate_kin. 1 hit. PTHR21060:SF11. AckA. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. ackA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_CALS8

Accession

Primary (citable) accession number: A4XL40

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 29, 2007
Last modified:	June 16, 2009
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)