Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A4XKZ4

- PUR5_CALS8

UniProt

A4XKZ4 - PUR5_CALS8

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSAC351627:GJ17-2035-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:Csac_1994
OrganismiCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
Taxonomic identifieri351627 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
ProteomesiUP000000256: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000083453Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351627.Csac_1994.

Structurei

3D structure databases

ProteinModelPortaliA4XKZ4.
SMRiA4XKZ4. Positions 16-336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiVIGKIEH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A4XKZ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTYKDAGVN IEEGYKAVNL IKNIAKETFD SNVITDIGSF GSMYLLNIEN
60 70 80 90 100
SDYILVSGTD GVGTKLKIAF YMDKHDTVGI DCVAMCVNDI LCHGAKPLFF
110 120 130 140 150
LDYIACGKLK SEKVATIVKG VAEGCKIAGC SLVGGETAEM PGFYREEEYD
160 170 180 190 200
LAGFAVGLVK KDLAICGQDV KEGDILIGLA SNGVHSNGYS LVRKVFGIDE
210 220 230 240 250
NPKVLTKVYE ELNLSLGEEL LKPTRIYVKP VLKVLEKIKI KGIAHITGGG
260 270 280 290 300
FFENIPRAFP KGFVAVIEKG TWNILPIFRL IQKYSKVDDN EMFSTFNMGI
310 320 330 340
GMVLIVSKDD VETAMEILNE EGINSYVIGT IEKGEGGVVL R
Length:341
Mass (Da):37,171
Last modified:May 29, 2007 - v1
Checksum:iE7BF642BF502BCE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000679 Genomic DNA. Translation: ABP67579.1.
RefSeqiWP_011917514.1. NC_009437.1.
YP_001180770.1. NC_009437.1.

Genome annotation databases

EnsemblBacteriaiABP67579; ABP67579; Csac_1994.
GeneIDi5088825.
KEGGicsc:Csac_1994.
PATRICi21253732. VBICalSac56748_2172.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000679 Genomic DNA. Translation: ABP67579.1 .
RefSeqi WP_011917514.1. NC_009437.1.
YP_001180770.1. NC_009437.1.

3D structure databases

ProteinModelPortali A4XKZ4.
SMRi A4XKZ4. Positions 16-336.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351627.Csac_1994.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP67579 ; ABP67579 ; Csac_1994 .
GeneIDi 5088825.
KEGGi csc:Csac_1994.
PATRICi 21253732. VBICalSac56748_2172.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi VIGKIEH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci CSAC351627:GJ17-2035-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43494 / DSM 8903.

Entry informationi

Entry nameiPUR5_CALS8
AccessioniPrimary (citable) accession number: A4XKZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3