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Protein

Uronate isomerase

Gene

uxaC

Organism
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucuronate = D-fructuronate.UniRule annotation
D-galacturonate = D-tagaturonate.UniRule annotation

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Uronate isomeraseUniRule annotation (EC:5.3.1.12UniRule annotation)
Alternative name(s):
Glucuronate isomeraseUniRule annotation
Uronic isomeraseUniRule annotation
Gene namesi
Name:uxaCUniRule annotation
Ordered Locus Names:Csac_1949
OrganismiCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)
Taxonomic identifieri351627 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
Proteomesi
  • UP000000256 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000447631 – 464Uronate isomeraseAdd BLAST464

Interactioni

Protein-protein interaction databases

STRINGi351627.Csac_1949.

Structurei

3D structure databases

ProteinModelPortaliA4XKU9.
SMRiA4XKU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uronate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D2H. Bacteria.
COG1904. LUCA.
HOGENOMiHOG000224075.
KOiK01812.
OMAiREMTTET.
OrthoDBiPOG091H07GL.

Family and domain databases

Gene3Di1.10.2020.10. 1 hit.
HAMAPiMF_00675. UxaC. 1 hit.
InterProiIPR032466. Metal_Hydrolase.
IPR003766. Uronate_isomerase.
IPR023177. Uronate_isomerase_dom2.
[Graphical view]
PfamiPF02614. UxaC. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.

Sequencei

Sequence statusi: Complete.

A4XKU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRFMDEDFL LNNQTAKVLY EKYAKDMPII DFHCHLNPKE IYENKKFRNI
60 70 80 90 100
TEVWLGGDHY KWRLMRANGI EEKYITGSAD DYEKFLAWAK TIPMAIGNPI
110 120 130 140 150
YHWTHLELKR YFGIDEILNE KSAPIIWEKA NKVLEELGAR DIILKSNVEV
160 170 180 190 200
ICTTDDPVDT LEYHLKLKDD KNFNVKVYPT FRPDKGVNIE RETFIPWVEK
210 220 230 240 250
LGEVYGKKIE SYDEFLDALK SRAEFFHSVG CRASDHAIDN MVFAEASFDE
260 270 280 290 300
VANIFKKALA GEKLTEIEVA KYKTYTLRFL GKVYSSLGWA MQLHINALRN
310 320 330 340 350
NNTRMFNILG PDTGYDSIND GHIALALVKF LDSLEKENSL PKTILYSLNP
360 370 380 390 400
KDNYVLATIM GSFQDGSIPG KMQLGAAWWF NDSKDGNLQQ MKDLANLGLL
410 420 430 440 450
SRFVGMVTDS RSFLSYARHE YFRRLLCKLI GEWVENGEYP YDLEALSRIV
460
QGVCYYNAKE YFGF
Length:464
Mass (Da):53,757
Last modified:May 29, 2007 - v1
Checksum:iD058551E517678CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000679 Genomic DNA. Translation: ABP67534.1.
RefSeqiWP_011917470.1. NC_009437.1.

Genome annotation databases

EnsemblBacteriaiABP67534; ABP67534; Csac_1949.
KEGGicsc:Csac_1949.
PATRICi21253646. VBICalSac56748_2129.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000679 Genomic DNA. Translation: ABP67534.1.
RefSeqiWP_011917470.1. NC_009437.1.

3D structure databases

ProteinModelPortaliA4XKU9.
SMRiA4XKU9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi351627.Csac_1949.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP67534; ABP67534; Csac_1949.
KEGGicsc:Csac_1949.
PATRICi21253646. VBICalSac56748_2129.

Phylogenomic databases

eggNOGiENOG4105D2H. Bacteria.
COG1904. LUCA.
HOGENOMiHOG000224075.
KOiK01812.
OMAiREMTTET.
OrthoDBiPOG091H07GL.

Enzyme and pathway databases

UniPathwayiUPA00246.

Family and domain databases

Gene3Di1.10.2020.10. 1 hit.
HAMAPiMF_00675. UxaC. 1 hit.
InterProiIPR032466. Metal_Hydrolase.
IPR003766. Uronate_isomerase.
IPR023177. Uronate_isomerase_dom2.
[Graphical view]
PfamiPF02614. UxaC. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUXAC_CALS8
AccessioniPrimary (citable) accession number: A4XKU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: November 2, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.