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A4XKT3

- PYRF_CALS8

UniProt

A4XKT3 - PYRF_CALS8

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Protein

Orotidine 5'-phosphate decarboxylase

Gene
pyrF, Csac_1933
Organism
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei108 – 1081Proton donor By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciCSAC351627:GJ17-1974-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:Csac_1933
OrganismiCaldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903)
Taxonomic identifieri351627 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
ProteomesiUP000000256: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Orotidine 5'-phosphate decarboxylaseUniRule annotationPRO_1000066460Add
BLAST

Proteomic databases

PRIDEiA4XKT3.

Interactioni

Protein-protein interaction databases

STRINGi351627.Csac_1933.

Structurei

3D structure databases

ProteinModelPortaliA4XKT3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000245747.
KOiK01591.
OMAiCRTSNAG.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.

Sequencei

Sequence statusi: Complete.

A4XKT3-1 [UniParc]FASTAAdd to Basket

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MLNFSDRLIE SIKKKNSVLI AGIDTSIENV PDYFIKRFYD REKSEIDNLK    50
TILFEYNRRI IDAVEENVVG VKFQAAFFEQ YSYHGFEVLH KLCEYAKNKK 100
LVVIFDGKRN DISSSAKGYS NAYLGETPVF GRKIRFFEFD AITTNPYLGQ 150
DGIKPFVEDC ERFKKGLFVL VKTSNPSSAD FQDLTVEDKY LFEVVAEKVY 200
EWGKNCVGKE GYSDIGAVVG ATQKEAAKRI REILPNSFLL VPGIGVQGGK 250
VEDLKYFVDS NNMGIIVNSS RDIIYAYKNY VHSDFEKSSY LASKSIKESI 300
NAAIS 305
Length:305
Mass (Da):34,635
Last modified:May 29, 2007 - v1
Checksum:i1ACEDD4BA66112C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000679 Genomic DNA. Translation: ABP67518.1.
RefSeqiWP_011917454.1. NC_009437.1.
YP_001180709.1. NC_009437.1.

Genome annotation databases

EnsemblBacteriaiABP67518; ABP67518; Csac_1933.
GeneIDi5089295.
KEGGicsc:Csac_1933.
PATRICi21253614. VBICalSac56748_2113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000679 Genomic DNA. Translation: ABP67518.1 .
RefSeqi WP_011917454.1. NC_009437.1.
YP_001180709.1. NC_009437.1.

3D structure databases

ProteinModelPortali A4XKT3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351627.Csac_1933.

Proteomic databases

PRIDEi A4XKT3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP67518 ; ABP67518 ; Csac_1933 .
GeneIDi 5089295.
KEGGi csc:Csac_1933.
PATRICi 21253614. VBICalSac56748_2113.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000245747.
KOi K01591.
OMAi CRTSNAG.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci CSAC351627:GJ17-1974-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43494 / DSM 8903.

Entry informationi

Entry nameiPYRF_CALS8
AccessioniPrimary (citable) accession number: A4XKT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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